Multifunctional Iron Oxide Nanoparticles for Diagnostics, Therapy and Macromolecule Delivery

Yen, Swee Kuan; Parameswaran, P.; Selvan, Subramanian Tamil

doi:10.7150/thno.4827

Cited by 162 publications

(104 citation statements)

References 82 publications

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“…Currently, super paramagnetic iron oxide nanoparticles (SPIONs) are used that incorporate positron emitters (e.g., 52-Mn, 59-Fe, and 124-I) and contain small surface molecules (peptides, organic molecules) that bind to tumor tissue [323,324]. Although the physiological functionality of the PET probe is limited by its attachment to a large nanoparticle, the combination provides high spatial resolution (MR) with high sensitivity (PET).…”

Section: Dual-modality Tracers/contrastsmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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State-of-the-art patient management frequently requires the use of non-invasive imaging methods to assess the anatomy, function or molecular-biological conditions of patients or study subjects. Such imaging methods can be singular, providing either anatomical or molecular information, or they can be combined, thus, providing "anato-metabolic" information. Hybrid imaging denotes image acquisitions on systems that physically combine complementary imaging modalities for an improved diagnostic accuracy and confidence as well as for increased patient comfort. The physical combination of formerly independent imaging modalities was driven by leading innovators in the field of clinical research and benefited from technological advances that permitted the operation of PET and MR in close physical proximity, for example. This review covers milestones of the development of various hybrid imaging systems for use in clinical practice and small-animal research. Special attention is given to technological advances that helped the adoption of hybrid imaging, as well as to introducing methodological concepts that benefit from the availability of complementary anatomical and biological information, such as new types of image reconstruction and data correction schemes. The ultimate goal of hybrid imaging is to provide useful, complementary and quantitative information during patient work-up. Hybrid imaging also opens the door to multi-parametric assessment of diseases, which will help us better understand the causes of various diseases that currently contribute to a large fraction of healthcare costs.

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Section: Dual-modality Tracers/contrastsmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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“…Они перспек-тивны для использования в катализе [1], при доставке лекарств [2] и генов [3], изучении микрореологических процессов [4], а также в качестве контрастных жидко-стей [5]. Несмотря на то что свойства металлов триады железа в массивных телах хорошо изучены, структурные и магнитные характеристики в наноразмерных объектах, таких как наночастицы, нанопроволоки и нанотрубки, требуют дополнительного исследования.…”

Section: Introductionunclassified

Структура И Физические Свойства Железных Нанотрубок, Полученных Методом Темплатного Синтеза

Шумская¹,

Канюков²,

Козловский³

et al. 2017

Физика Твердого Тела

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На базе полиэтилентерефталатовых темплатов методом электрохимического осаждения синтезированы железные нанотрубки с аспектным соотношением порядка 100. Методами сканирующей электронной микро-скопии, энергодисперсионного анализа, просвечивающей электронной микроскопии, дифракции электронов, рентгеноструктурного анализа и газопроницаемости проведено детальное исследование структурных и морфологических особенностей нанотрубок. При помощи вибрационной магнитометрии и мессбауэровской спектроскопии определены основные магнитные параметры, а также их зависимость от температуры.

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“…[22][23][24][25] SPION can be further functionalized by surface coating using proteins, peptides, antibodies, polymers, carbohydrates, aptamers, DNA, RNA, or oligosaccharides. 17 The composition and characteristics of the SPION surface have a strong influence on their stability, distribution, and biocompatibility, with regard to cellular uptake and cytotoxicity. Although commercially available SPION have been approved for human use, they present some risks when used for treatment purposes, and these are currently being reevaluated.…”

Section: Introductionmentioning

confidence: 99%

“…They exhibit high magnetization in the presence of an external magnetic field, whereas this magnetization is lost when the external magnetic field is removed. 17 MRI is an important noninvasive tool to visualize organs, tissues, and pathological changes or treatment outcomes. 18,19 In the field of chronic, systemic inflammatory autoimmune diseases, such as rheumatoid arthritis, there is a need for close and regular monitoring of disease activity.…”

Section: Introductionmentioning

confidence: 99%