Multifunctional inorganic/organic nanocomposite microspheres - reinventing eggs for bone repair applications

Hou, Yi; Jin, Mengmeng; Sun, Dan; Li, Junfeng; Bi, Ruiye; Zhang, Li

doi:10.1016/j.compositesb.2023.110644

Cited by 10 publications

(4 citation statements)

References 64 publications

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“…In this mineralization system, harbored ALP has been postulated to catalyze the hydrolysis of organic phosphorus grafted on the chains of the mPU polymer, resulting in the generation of inorganic phosphate ions, consequently acting as initiators of mineralization. Few studies have utilized enzymes-loaded MVs for direct mineralization, and the studies of vesicles have substantially introduced crystal nuclei (CaCO 3 , calcium/phosphorus-rich nucleus, HA) to induce the mineralized deposition. Amorphous apatite was observed on these vesicles surface and no significant crystallinity has been testified by TEM and SAED. , In contrast, the CaGP-modified PU has been emulsified and constructed microcompartments in this study that enable a confined space for the regulation of mineral growth.…”

Section: Resultsmentioning

confidence: 99%

“…Few studies have utilized enzymes-loaded MVs for direct mineralization, and the studies of vesicles have substantially introduced crystal nuclei (CaCO 3 , calcium/phosphorus-rich nucleus, HA) to induce the mineralized deposition. Amorphous apatite was observed on these vesicles surface and no significant crystallinity has been testified by TEM and SAED. , In contrast, the CaGP-modified PU has been emulsified and constructed microcompartments in this study that enable a confined space for the regulation of mineral growth.…”

Section: Resultsmentioning

confidence: 99%

“…Amorphous apatite was observed on these vesicles surface and no significant crystallinity has been testified by TEM and SAED. 14,38 In contrast, the CaGP-modified PU has been emulsified and constructed microcompartments in this study that enable a confined space for the regulation of mineral growth.…”

Section: In Vitro Biomineralization Carrying By Different Alp-loaded Bvsmentioning

confidence: 99%

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Enzyme-Activated Biomimetic Vesicles Confining Mineralization for Bone Maturation

Chen,

Zhao,

Tang

et al. 2024

ACS Appl. Mater. Interfaces

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Inspired by the crucial role of matrix vesicles (MVs), a series of biomimetic vesicles (BVs) fabricated by calcium glycerophosphate (CaGP) modified polyurethane were designed to mediate the mineralization through in situ enzyme activation for bone therapy. In this study, alkaline phosphatase (ALP) was harbored in the porous BVs by adsorption (Ad-BVs) or entrapment (En-BVs). High encapsulation of ALP on En-BVs was effectively self-activating by calcium ions of CaGP-modified PU that specifically hydrolyzed the organophosphorus (CaGP) to inorganic phosphate, thus promoting the formation of the highly oriented bone-like apatite in vitro. Enzyme-catalyzed kinetics confirms the regulation of apatite crystallization by the synergistic action of self-activated ALP and the confined microcompartments of BVs. This leads to a supersaturated microenvironment, with the En-BVs group exhibiting inorganic phosphate (Pi) levels 4.19 times higher and Ca 2+ levels 3.67 times higher than those of simulated body fluid (SBF). Of note, the En-BVs group exhibited excellent osteo-inducing differentiation of BMSCs in vitro and the highest maturity with reduced bone loss in rat femoral defect in vivo. This innovative strategy of biomimetic vesicles is expected to provide valuable insights into the enzyme-activated field of bone therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: In Vitro Biomineralization Carrying By Different Alp-loaded Bvsmentioning

confidence: 99%

See 1 more Smart Citation

Enzyme-Activated Biomimetic Vesicles Confining Mineralization for Bone Maturation

Chen,

Zhao,

Tang

et al. 2024

ACS Appl. Mater. Interfaces

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“…The current state of the global manufacturing sector is at an important point as conventional manufacturing methods are being closely examined due to their impacts on the environment. The rapid loss of limited resources, rising production of waste, and expanding emission of carbon dioxide require an essential review of industrial procedures [1]. The traditional continuous manufacturing methods, defined by their "take-make-dispose" strategy, have considerably influenced the destruction of the environment.…”

Section: Introductionmentioning

confidence: 99%

Reinventing Production: A Case Study on implementing the strategic Innovations in Sustainable Remanufacturing

Sharma,

Bhong,

Patil

et al. 2023

E3S Web Conf.

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The understanding of sustainable remanufacturing as an innovative method has come about as a solution to the ecological difficulties posed by industrial manufacturing. The present study investigates the concept of industrial reinvention via a review of novel practices in the field of remanufacturing. Remanufacturing is an organizational strategy that seeks to increase the operational lifecycle of items, hence reducing the production of waste and maximizing resource use. The remanufacturing process includes a thorough set of phases, involving removal, repair, and enhancement, with the goal of rebuilding already utilized products to their former functionality as well as performance standards. This study examines the current state of procedures, methods, and strategies that contribute to the evolution of the remanufacturing operation in an environmentally friendly form. The abstract underlines the urgent requirement for sustainable solutions in industrial production as a response to problems with the environment. The idea of remanufacturing has been suggested as an effective way to solve these issues. This recent discussion presents an easy-to-understand representation of the remanufacturing process, emphasizing its essential relevance in increasing the lifespan of goods and decreasing the production of waste. The subsequent section of the abstract describes the primary objective of the research, which is the investigation of novel methods in the field of green remanufacturing. The paper aims to investigate multiple methods, tools, and strategies that are currently impacting the emergence of remanufacturing companies.

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Harnessing potential of avian eggshell membrane derived collagen hydrolysate for bone tissue regeneration

Aggarwal,

Nath,

Pal

et al. 2024

Mol Biol Rep

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Multifunctional inorganic/organic nanocomposite microspheres - reinventing eggs for bone repair applications

Cited by 10 publications

References 64 publications

Enzyme-Activated Biomimetic Vesicles Confining Mineralization for Bone Maturation

Enzyme-Activated Biomimetic Vesicles Confining Mineralization for Bone Maturation

Reinventing Production: A Case Study on implementing the strategic Innovations in Sustainable Remanufacturing

Harnessing potential of avian eggshell membrane derived collagen hydrolysate for bone tissue regeneration

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