Multifunctional injectable pluronic-cystamine-alginate-based hydrogel as a novel cellular delivery system towards tissue regeneration

Dang, Le Hang; Doan, Phuong L.; Nhi, Tran Thi Yen; Nguyen, Duc‐Tho; Nguyen, Bich Tram; Nguyen, Thi Phuong; Trân, Ngoc Quyên

doi:10.1016/j.ijbiomac.2021.06.183

Cited by 36 publications

(14 citation statements)

References 51 publications

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“…HA, as a natural anionic glycosaminoglycan, has the moisturizing, lubricating, and anti-inflammatory functions . CYS is an organic disulfide formed by decarboxylation reaction of CYS acid after heating . CYS was grafted to HA by amidation reaction, which gives HA sufficient Schiff base reaction binding sites, and the disulfide bond also gives HA excellent antioxidant capacity .…”

Section: Resultsmentioning

confidence: 99%

“…34 CYS is an organic disulfide formed by decarboxylation reaction of CYS acid after heating. 35 CYS was grafted to HA by amidation reaction, which gives HA sufficient Schiff base reaction binding sites, and the disulfide bond also gives HA excellent antioxidant capacity. 36 In order to cross-link HA-CYS to form hydrogels, benzaldehyde-functionalized PFA with multiple aldehyde groups was chosen as the cross-linking agent of the hydrogels.…”

Section: Fabrication and Characterization Of Ha-cys/mentioning

confidence: 99%

See 1 more Smart Citation

Antibacterial Conductive UV-Blocking Adhesion Hydrogel Dressing with Mild On-Demand Removability Accelerated Drug-Resistant Bacteria-Infected Wound Healing

Yang

et al. 2022

ACS Appl. Mater. Interfaces

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The on-demand replacement of multifunctional hydrogel wound dressings helps to avoid bacterial colonization, and the on-demand painless peeling of tissue adhesive hydrogels on the wound site remains a major challenge to be solved. In this work, we design and develop a series of multifunctional dynamic Schiff base network hydrogels composed of cystamine-modified hyaluronic acid, benzaldehyde-functionalized poly(ethylene glycol)-co-poly(glycerol sebacate), and polydopamine@polypyrrole nanocomposite (PDA@PPy) with mild on-demand removability to enhance drug-resistant bacteria-infected wound healing. These hydrogels exhibited ideal injectable and self-healing properties, excellent tissue adhesion, in vivo hemostasis, good antioxidation, and conductivity. PDA@PPy inspired by melanin endows hydrogels with excellent antioxidant capacity, UV-blocking ability, and photothermal anti-infection ability. Based on the dynamic oxidation–reduction response of disulfide bonds inspired by the dissociation of the tertiary spatial structure transformation of poly-polypeptide chains, these hydrogels can achieve rapid painless on-demand removal under mild conditions by adding dithiothreitol. These multifunctional hydrogels significantly promoted collagen deposition and angiogenesis in the MRSA-infected full-thickness skin repair experiment. All the results showed that these multifunctional hydrogels with painless on-demand removal property showed great potential in clinical treatment of infected wounds.

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Section: Resultsmentioning

confidence: 99%

Section: Fabrication and Characterization Of Ha-cys/mentioning

confidence: 99%

Antibacterial Conductive UV-Blocking Adhesion Hydrogel Dressing with Mild On-Demand Removability Accelerated Drug-Resistant Bacteria-Infected Wound Healing

Yang

et al. 2022

ACS Appl. Mater. Interfaces

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“…These hydrogels with a significant degree of crosslinking exhibited the capability of surviving and proliferating mesenchymal stem cells (MSCs), offering them as suitable candidates for injectable self-crosslinking deployment in TE [ 46 ]. In another study, thermal-sensitive hydrogels were developed using cystamine-functionalized sodium alginate-g-pluronic F127, showing suitable antibacterial activities and good biocompatibility for long-term cell cultivation [ 47 ]. It was revealed that fibroblasts could attach to the hydrogels, which effectively mimic the porous structure of these hydrogels after five days of culture.…”

Section: Te-rm Applicationsmentioning

confidence: 99%

Alginate-Based Biomaterials in Tissue Engineering and Regenerative Medicine

2023

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Today, with the salient advancements of modern and smart technologies related to tissue engineering and regenerative medicine (TE-RM), the use of sustainable and biodegradable materials with biocompatibility and cost-effective advantages have been investigated more than before. Alginate as a naturally occurring anionic polymer can be obtained from brown seaweed to develop a wide variety of composites for TE, drug delivery, wound healing, and cancer therapy. This sustainable and renewable biomaterial displays several fascinating properties such as high biocompatibility, low toxicity, cost-effectiveness, and mild gelation by inserting divalent cations (e.g., Ca2+). In this context, challenges still exist in relation to the low solubility and high viscosity of high-molecular weight alginate, high density of intra- and inter-molecular hydrogen bonding, polyelectrolyte nature of the aqueous solution, and a lack of suitable organic solvents. Herein, TE-RM applications of alginate-based materials are deliberated, focusing on current trends, important challenges, and future prospects.

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“…The interaction between an encapsulated cell and hydrogel is insufficiently evidenced; however, cell encapsulation in the hydrogel was able to modify the breakdown rate of hydrogel, as this study demonstrated that hydrogel containing Schwann cells degraded quicker than hydrogel alone [ 74 ]. Cell-hydrogel interactions, such as cell adhesion and movement, must be elucidated to prove the viability of hydrogel applications [ 75 ]. Cell adhesion in the hydrogel guarantees its capacity to integrate with native tissue throughout the healing process.…”

Section: Tissue Engineering As a Promising Treatment For Glottic Insu...mentioning

confidence: 99%

Tissue Engineering as a Promising Treatment for Glottic Insufficiency: A Review on Biomolecules and Cell-Laden Hydrogel

Lokanathan

Baki

et al. 2022

Biomedicines

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Glottic insufficiency is widespread in the elderly population and occurs as a result of secondary damage or systemic disease. Tissue engineering is a viable treatment for glottic insufficiency since it aims to restore damaged nerve tissue and revitalize aging muscle. After injection into the biological system, injectable biomaterial delivers cost- and time-effectiveness while acting as a protective shield for cells and biomolecules. This article focuses on injectable biomaterials that transport cells and biomolecules in regenerated tissue, particularly adipose, muscle, and nerve tissue. We propose Wharton’s Jelly mesenchymal stem cells (WJMSCs), induced pluripotent stem cells (IP-SCs), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), insulin growth factor-1 (IGF-1) and extracellular vesicle (EV) as potential cells and macromolecules to be included into biomaterials, with some particular testing to support them as a promising translational medicine for vocal fold regeneration.

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Multifunctional injectable pluronic-cystamine-alginate-based hydrogel as a novel cellular delivery system towards tissue regeneration

Cited by 36 publications

References 51 publications

Antibacterial Conductive UV-Blocking Adhesion Hydrogel Dressing with Mild On-Demand Removability Accelerated Drug-Resistant Bacteria-Infected Wound Healing

Antibacterial Conductive UV-Blocking Adhesion Hydrogel Dressing with Mild On-Demand Removability Accelerated Drug-Resistant Bacteria-Infected Wound Healing

Alginate-Based Biomaterials in Tissue Engineering and Regenerative Medicine

Tissue Engineering as a Promising Treatment for Glottic Insufficiency: A Review on Biomolecules and Cell-Laden Hydrogel

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