Multifunctional hydroxyapatite with potential for application in theranostic nanomedicine

Barbosa, Amanda Alves; Júnior, Severino Alves; Mendes, Rosemairy Luciane; Lima, Ricardo Santana de; Ferraz, Andréa de Vasconcelos

doi:10.1016/j.msec.2020.111227

Cited by 22 publications

(13 citation statements)

References 38 publications

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“…Even when incubated with NPs at a fairly high concentration of 128 μg/mL (IR780), the hemolysis ratio of the blood sample was less than 3.4%. This ratio is much lower than that of the internationally recognized standard, according to the degree of hemolysis (< 2.0% non-hemolytic; 2.0%–5.0% slightly hemolytic; and > 5.0% hemolytic) from the ASTM D756 (American Society for Testing and Materials Designation) classiﬁcation 42 . These outcomes indicate that the TPZ/IR780@HSA–OPN NPs possessed prominent hemocompatibility in the tested concentration range.…”

Section: Resultsmentioning

confidence: 69%

Osteopontin targeted theranostic nanoprobes for laser-induced synergistic regression of vulnerable atherosclerotic plaques

Mao

Chen

et al. 2022

Acta Pharmaceutica Sinica B

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Section: Resultsmentioning

confidence: 69%

Osteopontin targeted theranostic nanoprobes for laser-induced synergistic regression of vulnerable atherosclerotic plaques

Mao

Chen

et al. 2022

Acta Pharmaceutica Sinica B

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“…HAP easily binds to both positive and negative molecules by simple adsorption and is used for delivery of molecules like antibiotics, contraceptives, acetylsalicylic acid, hormones, insulin and anticancer drugs [26][27][28]. The HAP doping/substitution with different kind of elements (Mg, Si, Sr, Eu, Zn, Ce) was proposed as a way to improve the drug loading [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

New Emerging Inorganic–Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids

Rocca

Rinaldi

Bruni

et al. 2022

J Inorg Organomet Polym

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In the pharmaceutical market, the need to find effective systems for the efficient release of poorly bioavailable drugs is a forefront topic. The inorganic–organic hybrid materials have been recognized as one of the most promising systems. In this paper, we developed new Hydroxypapatite@Furosemide hybrids with improved dissolution rates in different media with respect to the drug alone. The hybrids formation was demonstrated by SEM/EDS measurements (showing homogeneous distribution of the elements) and FT-IR spectroscopy. The drug was adsorbed onto hydroxyapatite surfaces in amorphous form, as demonstrated by XRPD and its thermal stability was improved due to the absence, in the hybrids, of melting and decomposition peaks typical of the drug. The Sr substitution on Ca sites in hydroxyapatite allows increasing the surface area and pore volume, foreseeing a high capacity of drug loading. The dissolution tests of the hybrid compounds show dissolution rates much faster than the drug alone in different fluids, and also their solubility and wetting ability is improved in comparison to furosemide alone.

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“…Hydroxyapatite nanoparticles due to their resemblance to the mineral phase of hard tissues have aroused curiosity in applying for drug delivery. Apart from the pharmacological characteristics they acquire, hydroxyapatite nanoparticles are found to be capable of accommodating both hydrophilic and hydrophobic molecules, unlike most of the documented organic nanocarriers. − In addition to therapy, bioimaging is an integral part of diagnosis for intracellular monitoring, analysis of any disease condition, as well as confirm the presence and distribution of uptaken nanocarriers. Bioimaging can be achieved by amalgamating luminescent entities with suitable nanocarriers.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Therapeutic Attributes of Luminescent Hydroxyapatite Nanoparticles in Codelivery Module

Simon

Chattopadhyay

Ghosh

2022

ACS Appl. Bio Mater.

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Imminent prospects of clinical importance have been accomplished through divergent treatment modalities implemented using nanoscale platforms. In the present study, hydroxyapatite nanoparticles doped with copper nanoclusters (HAPs) were explored for codelivery of a hydrophobic drug, namely, norfloxacin (NX), and a hydrophilic photosensitizer, such as methylene blue (MB). NX and MB were successfully homed into HAPs (MB-NX-HAPs), which further exhibited a pH-dependent release of both. With the objective of attaining an enhanced effect, MB-NX-HAPs were evaluated for combination therapy, involving chemotherapy and photodynamic therapy (PDT) with irradiation at 640 nm. The combinatorial therapy approach was initially applied for antibacterial therapy, which suggested a considerable reduction in bacterial growth of Gram-negative strain Pseudomonas aeruginosa MTCC 2488. Thereafter, the antiproliferative study performed in cancer cell lines (HeLa and MCF-7) revealed the efficiency of MB-NX-HAPs in bestowing a combinatorial effect through chemotherapy and PDT (irradiation at 640 nm). The combined effect exerted through MB-NX-HAPs subsequently induced reactive oxygen species (ROS) generation, cell cycle alteration, and apoptosis activation in cancer cells. The biocompatible nature of MB-NX-HAPs was appreciably shown through their minimal effect on the normal cell line (HEK-293). Additionally, HAPs through luminescence of copper nanoclusters were suggested to aid in bioimaging of cancer cell lines.

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Multifunctional hydroxyapatite with potential for application in theranostic nanomedicine

Cited by 22 publications

References 38 publications

Osteopontin targeted theranostic nanoprobes for laser-induced synergistic regression of vulnerable atherosclerotic plaques

Osteopontin targeted theranostic nanoprobes for laser-induced synergistic regression of vulnerable atherosclerotic plaques

New Emerging Inorganic–Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids

In Vitro Therapeutic Attributes of Luminescent Hydroxyapatite Nanoparticles in Codelivery Module

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