Multifunctional hybrid skin patch for wearable smart healthcare applications

Yoon, Sanghyuk; Yoon, Hyosang; Zahed, Md Abu; Park, Chani; Kim, Dongkyun; Park, Jae Yeong

doi:10.1016/j.bios.2021.113685

Cited by 46 publications

(32 citation statements)

References 59 publications

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“…[ 7–10 ] Recent works, including our own, have demonstrated the importance of integrating different modalities (physical and chemical) into a single platform for real‐time and simultaneous sensing of multiple parameters, such as combining ECG with lactate, ECG with glucose, and blood pressure with glucose and lactate to monitor the cardiovascular state and metabolites. [ 11–13 ] In these works, the performances of the EP and biochemical sensors were comparatively lower due to the lack of conformal skin‐electrode contact, less flexibility, design and fabrication challenges, and the integration of transduction materials with high surface area. Moreover, to the best of our knowledge, in‐depth investigations of electrophysiological (EP) parameters; ECG, EMG, EEG, and temperature, with precise glucose level determination using an integrated multimodal epidermal patch have not been performed.…”

Section: Introductionmentioning

confidence: 99%

A Nanoporous Carbon‐MXene Heterostructured Nanocomposite‐Based Epidermal Patch for Real‐Time Biopotentials and Sweat Glucose Monitoring

Zahed

Sharifuzzaman

Yoon

et al. 2022

Adv Funct Materials

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Despite substantial progress in the development of wearable and flexible monitoring systems that conform to the epidermis, most designs focus on either physiological signs such as the electrocardiogram (ECG) results, respiration rate, or metabolites, and ignore the dynamic fluctuations of pH and temperature in sweat during on‐body tests. An advanced butterfly‐inspired hybrid epidermal biosensing (bi‐HEB) patch is presented here, which is interfaced with a custom‐developed miniaturized monitoring system. The patch incorporates a novel transducing layer of nanoporous carbon and MXene (NPC@MXene) for sensitive and durable detection of biomarkers in sweat. The bi‐HEB patch is composed of a glucose biosensor accompanied by pH and temperature sensors to precisely quantify glucose as well as two biopotential electrodes, allowing real‐time recording of electrophysiological (EP) signals. The NPC@MXene‐based glucose biosensor demonstrates an excellent sensitivity of 100.85 µAmm−1 cm−2 within physiological levels (0.003−1.5 mm), and variations in pH and temperature during on‐body perspiration monitoring are calibrated by employing a correction approach. In parallel, the EP electrodes exhibit skin‐electrode contact impedance and biopotential signals similar to those of conventional Ag/AgCl electrodes. Finally, the bi‐HEB patch integrated wearable system is used to accurately monitor sweat glucose and ECG of human subjects participating in indoor physical activities.

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Section: Introductionmentioning

confidence: 99%

A Nanoporous Carbon‐MXene Heterostructured Nanocomposite‐Based Epidermal Patch for Real‐Time Biopotentials and Sweat Glucose Monitoring

Zahed

Sharifuzzaman

Yoon

et al. 2022

Adv Funct Materials

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“…It is low-cost, making it a practical SSD in a disposable format [ 103 ]. Wearable epidermal patches in SSDs typically come in various forms, such as skin patches [ 104 ], tattoos [ 105 , 106 ], and bandages [ 107 , 108 ], as shown in Figure 4 b–d. The elements of substrate epidermal patches can promote strong skin adhesion, high mechanical strength, stretchability, and resilience in water conditions to manipulate physical skin performance.…”

Section: Sweat-sensing Device (Ssd)mentioning

confidence: 99%

“… Types of wearable devices in sweat-sensing devices. ( a ) Sweatband [ 54 ]; ( b ) skin patch; reprinted from [ 104 ], copyright (2022), with permission from Elsevier. ( c ) Tattoo patch [ 106 ]; ( d ) bandage of epidermal patch [ 125 ] (Reused with the permission of copyright 2014, John Wiley, and Sons).…”

Section: Sweat-sensing Device (Ssd)mentioning

confidence: 99%

“…The life span of the developed sensors was kept stable, with minimal drift of measurement values in current or voltage. In addition, blood testing, together with sweat analysis, can provide a good comparison and evaluate whether both biofluid samples have a strong correlation in order to check the reliability of the created sensor device and the practicability of the sweat sampling analysis for certain biomarkers [ 14 , 104 ]. Sweat has remained comparatively unexplored in comparison to standard biofluids, such as blood, despite its great promise for noninvasive physiological monitoring.…”

Section: Recent Advances Of Ssds: Optimal In Designs Functionalities ...mentioning

confidence: 99%

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A Comprehensive Review of the Recent Developments in Wearable Sweat-Sensing Devices

Ibrahim

Sabani

Johari

et al. 2022

Sensors

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Sweat analysis offers non-invasive real-time on-body measurement for wearable sensors. However, there are still gaps in current developed sweat-sensing devices (SSDs) regarding the concerns of mixing fresh and old sweat and real-time measurement, which are the requirements to ensure accurate the measurement of wearable devices. This review paper discusses these limitations by aiding model designs, features, performance, and the device operation for exploring the SSDs used in different sweat collection tools, focusing on continuous and non-continuous flow sweat analysis. In addition, the paper also comprehensively presents various sweat biomarkers that have been explored by earlier works in order to broaden the use of non-invasive sweat samples in healthcare and related applications. This work also discusses the target analyte’s response mechanism for different sweat compositions, categories of sweat collection devices, and recent advances in SSDs regarding optimal design, functionality, and performance.

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“…Wearable sensors can overcome this issue by conducting in situ sweat analysis for real-time results. [21][22][23][24][25][26] Wearable sensors have been demonstrated for detecting numerous metabolites such as glucose, [17,22,24,[27][28][29] uric acid, [30,31] ascorbic acid, [32,33] ions, [34][35][36][37][38] etc. A robust selfpowered sweat sensor was developed by Li and coworkers which shows the capability of sensing the concentration fluctuations of Na + and K + during exercises.…”

Section: Introductionmentioning

confidence: 99%

An Integrated Wearable Sweat Sensing Patch for Passive Continuous Analysis of Stress Biomarkers at Rest

Zhao

Zhang

Qin

et al. 2022

Adv Funct Materials

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Real-time monitoring of mental stress biomarkers in sweat provides the possibility to evaluate mental status in a precise manner. In general, wearable sweat sensors suffer from inconvenient sweat collection, low levels of diagnostic biomarkers in sweat, sophisticated signal processing, and challenges with data visualization. To overcome these challenges, herein an integrated wearable sweat-sensing patch for continuous analysis of stress biomarkers (cortisol, Mg 2+ , and pH) at rest is demonstrated. The sweat sensing patch comprised a microfluidic chip, a highly sensitive sensing platform, an on-site signal processing circuitry (SPCs), and a smartphone installed with a homedeveloped display software. The sweat collection at rest is realized using a microfluidic chip without perspiration assistance. A ternary composite electrode is designed to obtain good conductivity, high surface area, and massive reactive sites, thereby yielding excellent electrochemical performances and high sensitivity to trace stress biomarkers. The on-site SPC has the function of signal transduction, conditioning, processing, and wireless transmission. The detection results can be displayed on a smartphone through the software. This work represents a significant scientific and technological advancement toward indexing mental stress status and can be used as an innovative tool for psychological diagnosis.

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Multifunctional hybrid skin patch for wearable smart healthcare applications

Cited by 46 publications

References 59 publications

A Nanoporous Carbon‐MXene Heterostructured Nanocomposite‐Based Epidermal Patch for Real‐Time Biopotentials and Sweat Glucose Monitoring

A Nanoporous Carbon‐MXene Heterostructured Nanocomposite‐Based Epidermal Patch for Real‐Time Biopotentials and Sweat Glucose Monitoring

A Comprehensive Review of the Recent Developments in Wearable Sweat-Sensing Devices

An Integrated Wearable Sweat Sensing Patch for Passive Continuous Analysis of Stress Biomarkers at Rest

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