Multifunctional hybrid nanoparticles in diagnosis and therapy of breast cancer

Rajana, Naveen; Mounika, Aare; Chary, Padakanti Sandeep; Bhavana, Valamla; Urati, Anuradha; Khatri, Dharmendra Kumar; Singh, Shashi Bala; Mehra, Neelesh Kumar

doi:10.1016/j.jconrel.2022.11.009

Cited by 35 publications

(16 citation statements)

References 200 publications

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“…The core comprises a polymer encapsulating therapeutic substances surrounded by a lipid layer shell. [31][32][33] The lipid layer shell confers biocompatibility to the LPNPs and prevents the encapsulated contents from leaking. The stealthy PEGylated lipid on the surfaces can also enhance their in vivo circulation.…”

Section: Development Of Lipid-based Nanoparticlesmentioning

confidence: 99%

Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticlesin vivo

Zhong

Zheng

et al. 2023

Biomater. Sci.

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Section: Development Of Lipid-based Nanoparticlesmentioning

confidence: 99%

Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticlesin vivo

Zhong

Zheng

et al. 2023

Biomater. Sci.

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“…However, the single‐component INP structure may not fully meet the diverse clinical needs. Most of the currently developed multifunctional NPs contain two or more inorganic nanomaterials, or carry multiple cargoes 178,179 . The clinical translation of multifunctional NPs is limited due to the complexity of their preparation process or unsatisfactory performance in a single function 180 .…”

Section: Inp‐integrated Mscs For Simultaneous Treatment and Trackingmentioning

confidence: 99%

Inorganic nanoparticle‐integrated mesenchymal stem cells: A potential biological agent for multifaceted applications

Zheng,

Jiang,

et al. 2023

MedComm

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Mesenchymal stem cell (MSC)‐based therapies are flourishing. MSCs could be used as potential therapeutic agents for regenerative medicine due to their own repair function. Meanwhile, the natural predisposition toward inflammation or injury sites makes them promising carriers for targeted drug delivery. Inorganic nanoparticles (INPs) are greatly favored for their unique properties and potential applications in biomedical fields. Current research has integrated INPs with MSCs to enhance their regenerative or antitumor functions. This model also allows the in vivo fate tracking of MSCs in multiple imaging modalities, as many INPs are also excellent contrast agents. Thus, INP‐integrated MSCs would be a multifunctional biologic agent with great potential. In this review, the current roles performed by the integration of INPs with MSCs, including (i) enhancing their repair and regeneration capacity via the improvement of migration, survival, paracrine, or differentiation properties, (ii) empowering tumor‐killing ability through agent loaded or hyperthermia, and (iii) conferring traceability are summarized. An introduction of INP‐integrated MSCs for simultaneous treatment and tracking is also included. The promising applications of INP‐integrated MSCs in future treatments are emphasized and the challenges to their clinical translation are discussed.

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“…Chemotherapy is a traditional malignant tumor cure method in clinical application . Most chemotherapeutic drugs are far from the targeting capacity at the tumor sites, and high dose administration is usually implemented to maintain the therapeutic drug concentration at the expense of serious side effect to normal tissue cells. , In addition, many nontargeting chemotherapeutic drugs enter the circulatory system blood and are cleared easily. − In this connection, a variety of nanocarriers, such as metal nanoparticles, polymeric nanoparticles, and polypeptide nanogels, were designed to improve the drug transportation ratio and reduce the clearance of drugs from the reticuloendothelial system. − Among them, Pluronic F-127 was the most widely used due to its excellent biocompatibility. For example, Zhang et al took advantage of Cas9 and chlorophyll-functionalized Pluronic F-127 micelles for effective A549 tumor therapy .…”

Section: Introductionmentioning

confidence: 99%

Active-Targeting Biomimetic Polymer Nanoparticles for NIR Fluorescence Imaging and Enhanced Chemo-Sonodynamic Therapy of Cancer

Jin,

Zhang,

Tang

et al. 2024

ACS Appl. Nano Mater.

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Combination therapy has been demonstrated to be an effective strategy for cancer therapy. Herein, FA-GCM@PF127/ICG/TM biomimetic nanoparticles targeting tumor cells were developed for combined chemo-sonodynamic therapy against glioma. The chemotherapeutic drug Temozolomide (TM) and the ultrasonic agent indocyanine green (ICG) were loaded into the hydrophobic motif and hydrophilic motif of Pluronic F-127 (PF127) and self-assembled to the PF127/ICG/TM nanoparticle core. Tumor-specific targeting folate (FA) ligand-functionalized glioma cancer cell membrane was coated on the surface of the PF127/ICG/TM core to play the role of a “disguiser”. FA-GCM/PF127/ICG/TM nanoparticles targeted tumor cells under the concerted effort of the homologous glioma cancer cell membranes (GCM) and specifically the binding between FA ligand and tumor overexpressed FA receptor. ICG provides high-fidelity near-infrared fluorescence imaging to illuminate the tumor and stimulates the production of reactive oxygen to kill tumor cells upon ultrasonic irritation. In vitro and in vivo experiments demonstrated that FA-GCM@PF127/ICG/TM nanoparticles presented excellent biocompatibility. GL261 tumor-bearing C57BL/6 mice treatment results show that the FA-GCM@PF127/ICG/TM nanoparticles combined chemotherapy and sonodynamic therapy together to greatly improve the tumor therapeutic effect. FA-GCM@PF127/ICG/TM biomimetic polymer nanoparticles are promising to provide a strategy for near-infrared fluorescence imaging and enhanced chemo-sonodynamic therapy.

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Multifunctional hybrid nanoparticles in diagnosis and therapy of breast cancer

Cited by 35 publications

References 200 publications

Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticlesin vivo

Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticlesin vivo

Inorganic nanoparticle‐integrated mesenchymal stem cells: A potential biological agent for multifaceted applications

Active-Targeting Biomimetic Polymer Nanoparticles for NIR Fluorescence Imaging and Enhanced Chemo-Sonodynamic Therapy of Cancer

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