Multifunctional Hybrid MoS2-PEGylated/Au Nanostructures with Potential Theranostic Applications in Biomedicine

Abstract

In this work, flower-like molybdenum disulfide (MoS2) microspheres were produced with polyethylene glycol (PEG) to form MoS2-PEG. Likewise, gold nanoparticles (AuNPs) were added to form MoS2-PEG/Au to investigate its potential application as a theranostic nanomaterial. These nanomaterials were fully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), photoelectron X-ray spectroscopy (XPS), Fourier-transformed infrared spectroscopy (FTIR), cyclic voltammetry and impedance spectroscopy. The produced hierarchical MoS2-PEG/Au microstructures showed an average diameter of 400 nm containing distributed gold nanoparticles, with great cellular viability on tumoral and non-tumoral cells. This aspect makes them with multifunctional characteristics with potential application for cancer diagnosis and therapy. Through the complete morphological and physicochemical characterization, it was possible to observe that both MoS2-PEG and MoS2-PEG/Au showed good chemical stability and demonstrated noninterference in the pattern of the cell nucleus, as well. Thus, our results suggest the possible application of these hybrid nanomaterials can be immensely explored for theranostic proposals in biomedicine.

Insights into Gold Nanoparticles Possibilities for Diagnosis and Treatment of the Head and Neck Upper Aerodigestive Tract Cancers

“…Due to their unique optical properties, AuNPs represent an important nanomaterial for biomedical procedures. Even when combined with other nanomaterials, AuNPs may help increase cellular biocompatibility [ 64 ]. Some level of cytotoxicity appears when AuNPs are used in biological assays.…”

Molybdenum disulfide polymeric nanoarchitectures and applications: A review

“…SEM images (Figure 14A-D) expose that individual microsphere was constituted of severally curled ultra-thin nanosheets dispersed at the surface, as MoS 2 intersheet spacing depicted approximately 0.54 nm. 62 63 Generally, potential application areas of MoS 2 @PNC are elucidated in Figure 18. 63 PP@exfoliated MoS (EMoS 2 ) nanoarchitectures.…”

“…62 63 Generally, potential application areas of MoS 2 @PNC are elucidated in Figure 18. 63 PP@exfoliated MoS (EMoS 2 ) nanoarchitectures. 63 Fabricated PP@EMoS 2 nanoarchitectures isotactic index values were very high (99%, varying from 98.1% to 99.0%).…”

“…63 PP@exfoliated MoS (EMoS 2 ) nanoarchitectures. 63 Fabricated PP@EMoS 2 nanoarchitectures isotactic index values were very high (99%, varying from 98.1% to 99.0%). Inclusion of EMoS 2 notably enhanced PP thermal stability in addition to mechanical features (modulus, tensile strength, and elongation at break).…”

“…The architectural behavior of MoS 2 @Ziegler-Natta catalyst was subjected to SEM characterization and garnered images are presented in Figure 15B (a, b). 63 In a bid to study the distribution of EMoS 2 within PP matrix, garnered PP with PP@EMoS 2 nanoarchitectures underwent hot-pressing to form films visualized for transparency via optical microscope. Here, the garnered micrographic images are presented in Figure 16.…”