Multifunctional hybrid magnetite nanoparticles with pH‐responsivity, superparamagnetism and fluorescence

Abstract

Multifunctional hybrid nanoparticles, Fe 3 O 4 @poly[(2-dimethylamino)ethyl methacrylate]-block-poly(2-hydroxyethyl methacrylate)-graft-carbazole, with pH-responsivity, superparamagnetism and fluorescence for targeted drug delivery and release have been synthesized. The nanoparticles have a core-shell structure as determined from transmission electron microscopy, pH-responsivity as determined from hydrodynamic radius analysis, superparamagnetism as determined from vibrating sample magnetometry and fluorescence as determined from fluorescence spectroscopy and fluorescence microscopy. The release behavior of model drug progesterone indicates that the release rate can be effectively controlled by altering the pH of the environment. The multifunctional nanoparticles could be applied extensively in targeted drug delivery and release, and with fluorescence they can serve as efficient tracers to record magnetic targeting routes. Scheme 2. Schematic of effect of change of pH.

Hybrid nanoparticles with CO2-responsive shells and fluorescence-labelled magnetic cores

“…[17][18][19][20][21] There are several techniques to prepare polymer brushes on the surface of inorganic nanoparticles: the "graing to", "graing from" and "graing through" methods. [22][23][24][25][26][27][28][29][30] In our previous work, 20,21 by using these methods, SPION were modied with special polymer brushes, which endowed them with properties including the ability to recognize and bind, catalyze or uoresce.…”

Poly (N-Isopropyl Acrylamide-<i>Co</i>-Vanillin Acrylate) Dual Responsive Functional Copolymers for Grafting Biomolecules by Schiff’s Base Click Reaction

“…A review article has been published by Yuan et al, covering the most interested articles used Schiff base as a stimuli-responsive linker in the polymer Open Journal of Organic Polymer Materials chain [46]. The sensitivity of the imine linkage to pH value is responsible on the responsive feature of the polymer molecule [47] [48]. Moreover, the formation of complexes of the imine can also be used to expand the pH responsiveness of the linker [48]- [53].…”

Optically Active Polymer Via One‐Pot Combination of Chemoenzymatic Transesterification and RAFT Polymerization: Synthesis and Its Application in Hybrid Silica Particles

“…Combining inorganic and polymer, inorganic/polymer composite materials with the excellent performance can be widely applied in the fields of the mechanism, optics, electronics, immobilization, separation, catalysis, and biology, etc., and now are gradually becoming a new hotspot in material field . More importantly, when inorganic particles are encapsulated by polymers, the resulted hybrid particles have the advantages of good dispersibility and high stability, and the functional groups on the surface can be utilized for further modification . Due to the chemical resistance, mechanical stability, relatively low costs, high specific surface area, inorganic silica particles turn out to be ideally fitted for a solid substrate .…”