Multifunctional gold coated iron oxide core-shell nanoparticles stabilized using thiolated sodium alginate for biomedical applications

Sood, Ankur; Arora, Varun; Shah, Jyoti; Jain, Tapan K.

doi:10.1016/j.msec.2017.05.079

Cited by 116 publications

(63 citation statements)

References 39 publications

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“…Hereby, magnetic/plasmonic nanoparticles afford a high therapeutic potentiality owing to the combination of different strategies, such as photothermia, photodynamic therapy, magnetic hyperthermia, and magnetic-guided drug delivery [19]. In this context, iron-oxide magnetic nanoparticles covered with gold or carbon were used [20][21][22]. Recently, manganese ferrite/gold core/shell nanoparticles entrapped in lipid bilayers were also developed as nanocarriers for antitumor drugs [23].Considering these advantages, in this work, both core/shell nickel ferrite/gold nanoparticles and gold-decorated nickel ferrite nanoparticles were prepared.…”

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confidence: 99%

Development of Novel Magnetoliposomes Containing Nickel Ferrite Nanoparticles Covered with Gold for Applications in Thermotherapy

Rio

Rodrigues

et al. 2020

Materials

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Multifunctional nanosystems combining magnetic and plasmonic properties are a promising approach for cancer therapy, allowing magnetic guidance and a local temperature increase. This capability can provide a triggered drug release and synergistic cytotoxic effect in cancer cells. In this work, nickel ferrite/gold nanoparticles were developed, including nickel ferrite magnetic nanoparticles decorated with plasmonic gold nanoparticles and core/shell nanostructures (with a nickel ferrite core and a gold shell). These nanoparticles were covered with a surfactant/lipid bilayer, originating liposome-like structures with diameters below 160 nm. The heating capacity of these systems, upon excitation with light above 600 nm wavelength, was assessed through the emission quenching of rhodamine B located in the lipid layer. The developed nanosystems show promising results for future applications in thermotherapy.Materials 2020, 13, 815 2 of 19 field, with no remnant magnetization upon magnetic field removal [11][12][13][14]. Generally, nickel ferrite nanoparticles are superparamagnetic when their size is smaller than a critical diameter of around 30 nm [15]. However, nickel-based nanoparticles present some issues such as potential toxicity, high reactivity, and easy degradation, due to the high surface/volume ratio [16]. In order to overcome these problems and make them suitable for biological applications, nickel-containing nanoparticles are usually protected by a suitable coating, such as lipids, polymers, or silica [15,[17][18][19].Combined therapies provide a promising solution for addressing tumor heterogeneity and drug resistance issues, exploring synergistic effects of the different mechanisms of action of multiple therapies, and achieving multiple targets. Hereby, magnetic/plasmonic nanoparticles afford a high therapeutic potentiality owing to the combination of different strategies, such as photothermia, photodynamic therapy, magnetic hyperthermia, and magnetic-guided drug delivery [19]. In this context, iron-oxide magnetic nanoparticles covered with gold or carbon were used [20][21][22]. Recently, manganese ferrite/gold core/shell nanoparticles entrapped in lipid bilayers were also developed as nanocarriers for antitumor drugs [23].Considering these advantages, in this work, both core/shell nickel ferrite/gold nanoparticles and gold-decorated nickel ferrite nanoparticles were prepared. These nanoparticles were covered with a surfactant/lipid bilayer, forming the so-called solid magnetoliposomes. The local heating capacity of these nanosystems was assessed through the inhibition of fluorescence of a fluorophore linked to the lipid layer, when the systems were excited with a light source. The new nanosystems exhibit a strong potential to promote local heating, making them promising for photothermia applications. Materials and MethodsIn all preparations, spectroscopic-grade solvents and ultrapure water of Milli-Q grade (MilliporeSigma, St. Louis, MO, USA) were used. Preparation of Nickel Ferrite/Gold Nanoparticles Pre...

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mentioning

confidence: 99%

Development of Novel Magnetoliposomes Containing Nickel Ferrite Nanoparticles Covered with Gold for Applications in Thermotherapy

Rio

Rodrigues

et al. 2020

Materials

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“…MRI equipment exerts a strong magnetic field within the CAs as well as other magnetic particles of biological significance respond (Hachani et al, 2016). MRI contrasting agents are classified into five categories as: T 1 , T 2 /T * 2 , CEST, 19 F-based and hyperpolarized agents (T 1 and T 2 are relaxation rates) (Sood et al, 2017).…”

Section: Imagingmentioning

confidence: 99%

A Comprehensive Review of Magnetic Nanomaterials Modern Day Theranostics

Gul

Khan

Rehman³

et al. 2019

Front. Mater.

228

134

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Substances at nanoscale, commonly known as "nanomaterials," have always grabbed the attention of researchers for hundreds of years. Among these different types of nanomaterials, magnetic nanomaterials have been the focus of considerable attention during the last two decades as evidenced by an unprecedented increase in the number of research papers focusing these materials. Iron oxide magnetic nanoparticles have occupied a vital position in imaging phenomena; as drug vehicles, controlled/sustained release phenomena and hyperthermia; atherosclerosis diagnosis; prostate cancer. In fact, these are wonderful "theranostic" agents with some under clinical trials for human use. In this review, we have attempted to highlight the advances taking place in the field of magnetic nanoparticles as theranostic agents. Extensive progress has been made in the two most important parameters, namely, control over the size and shape which decide the importance of iron oxide magnetic nanoparticles by developing suitable procedures like precipitation, co-precipitation, thermal decomposition, hydrothermal synthesis, microemulsion synthesis and plant mediated synthesis. After using a suitable synthetic route, workers encounter the most daunting task linked with the materials at nanoscale i.e., the protection against corrosion. Only properly protected iron oxide magnetic nanoparticles can be further connected to different functional systems to make building blocks for application in catalysis, biology and medicines. Finally, "theranostics" which is a combined application of imaging and drug delivery has been discussed. With all the potential uses, toxicity of the of iron oxide magnetic nanoparticles has been discussed.

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“…The oxidized sodium alginate not only increases biostability, improves degradation but also retains the properties before modification. Modification of surface chemical groups on sodium alginate can improve drug‐loading performance . The introduction of an aldehyde group can also be coupled to a polypeptide, certain amino acids, and aminated quantum dots to make the cells and biological materials more powerful.…”

Section: Introductionmentioning

confidence: 99%

“…Modification of surface chemical groups on sodium alginate can improve drug-loading performance. 34 The introduction of an aldehyde group can also be coupled to a polypeptide, certain amino acids, and aminated quantum dots to make the cells and biological materials more powerful. Previous reports have demonstrated that biotinylated polymers can be targeted for uptake by cancer cells.…”

Section: Introductionmentioning

confidence: 99%

pH‐sensitive carbon quantum dots−doxorubicin nanoparticles for tumor cellular targeted drug delivery

Bao

Hollywood

Wang

et al. 2019

Polymers for Advanced Techs

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A kind of pH‐responsive carbon quantum dots−doxorubicin nanoparticles drug delivery platform (D‐Biotin/DOX‐loaded mPEG‐OAL/N‐CQDs) was designed and synthesized. The system consists of fluorescent carbon dots as cross‐linkers, and D‐Biotin worked as targeting groups, which made the system have a pH correspondence, doxorubicin hydrochloride (DOX) as the target drug, oxidized sodium alginate (OAL) as carrier materials. Ultraviolet (UV)‐Vis spectrum showed that the drug‐loading rate of DOX is 10.5%, and the drug release in vitro suggested that the system had a pH response and tumor cellular targeted, the drug release rate is 65.6% at the value of pH is 5.0, which is much higher than that at the value of pH is 7.4. The cytotoxicity test and laser confocal fluorescence imaging showed that the synthesized drug delivery system has high cytotoxicity to cancer cells, and the drug‐loaded nanoparticles could enter the cells through endocytosis.

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Multifunctional gold coated iron oxide core-shell nanoparticles stabilized using thiolated sodium alginate for biomedical applications

Cited by 116 publications

References 39 publications

Development of Novel Magnetoliposomes Containing Nickel Ferrite Nanoparticles Covered with Gold for Applications in Thermotherapy

Development of Novel Magnetoliposomes Containing Nickel Ferrite Nanoparticles Covered with Gold for Applications in Thermotherapy

A Comprehensive Review of Magnetic Nanomaterials Modern Day Theranostics

pH‐sensitive carbon quantum dots−doxorubicin nanoparticles for tumor cellular targeted drug delivery

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