Multifunctional Fibers to Shape Future Biomedical Devices

Zhang, Ye; Ding, Jianxun; Qi, Baokun; Tao, Wei; Wang, Junqing; Zhao, Caiyan; Peng, Huisheng; Shi, Jinjun

doi:10.1002/adfm.201902834

Cited by 87 publications

(56 citation statements)

References 97 publications

(118 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The emergence of smart microcarriers revealed new opportunities for scientists to develop the most efficient anti-disease vehicles with safe and biocompatible profiles [8,9]. Recent developments focused on the fabrication of polymeric devices with multiple biomedical functions to improve the quality of treatment and healthcare management [10]. Microcarriers fabricated from biocompatible and biodegradable polymers through various techniques are widely used for advanced biomedical applications, such as pharmaceutical repositories, tissue engineering scaffolds, wound healing, sensors, and systematic drug delivery [11].…”

Section: Introductionmentioning

confidence: 99%

Smart Microneedles with Porous Polymer Coatings for pH-Responsive Drug Delivery

et al. 2019

View full text Add to dashboard Cite

This work demonstrates a simple approach for coating a porous polymer layer on stainless-steel (SS) microneedles characterized by a pH-responsive formulation for self-regulated drug delivery. For many drug-delivery applications, the release of therapeutic agents in an acidic microenvironment is desirable. Acid-sensitive polymers and hydrogels were extensively explored, but easily prepared polymeric microcarriers that combine acid sensitivity and biodegradability are rare. Here, we describe a simple and robust method of coating a porous polymer layer on SS microneedles (MNs) that release a model drug (lidocaine) in a pH-responsive fashion. It was constructed by packing the model drug and a pH-sensitive component (sodium bicarbonate) into the pores of the polymer layer. When this acid-sensitive formulation was exposed to the acidic microenvironment, the consequent reaction of protons (H+) with sodium bicarbonate (NaHCO3) yielded CO2. This effect generated pressure inside the pores of the coating and ruptured the thin polymer membrane, thereby releasing the encapsulated drug. Scanning electron micrographs showed that the pH-sensitive porous polymer-coated MNs exposed to phosphate-buffered saline (PBS) at pH 7.4 were characterized by closed pores. However, MNs exposed to PBS at pH 5.5 consisted of open pores and the thin membrane burst. The in vitro studies demonstrated the pH sensitivity of the drug release from porous polymer-coated MNs. Negligible release was observed for MNs in receiving media at pH 7.4. In contrast, significant release occurred when the MNs were exposed to acidic conditions (pH 5.5). Additionally, comparable results were obtained for drug release in vitro in porcine skin and in PBS. This revealed that our developed pH-responsive porous polymer-coated MNs could potentially be used for the controlled release of drug formulations in an acidic environment. Moreover, the stimuli-responsive drug carriers will enable on-demand controlled release profiles that may enhance therapeutic effectiveness and reduce systemic toxicity.

show abstract

Section: Introductionmentioning

confidence: 99%

Smart Microneedles with Porous Polymer Coatings for pH-Responsive Drug Delivery

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Another pivotal affair in mimicking the hierarchical structure of woven bone was to construct the 3D ECM architecture (Zhang et al, 2019c). The ECM has a prominent interpore connectivity and an ideal bone substitute should provide a similar interconnected pore structure to support cell attachment and migration as well as the circulation of nutrients (Zadpoor, 2015;Zhang Y. et al, 2019;Zhu et al, 2019). The optimal pore size recommended is recommended over 300 µm and the porosity is preferably in the range from 70 to 90% (Turco et al, 2009;Tian et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

The Injectable Woven Bone-Like Hydrogel to Perform Alveolar Ridge Preservation With Adapted Remodeling Performance After Tooth Extraction

Xie

Liao

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Grafting bone substitute is paramount to prevent the alveolar ridge resorption after tooth extraction and facilitate the subsequent implant treatment. An ideal bone substitute should acquire the excellent osteogenic property, more importantly, possess the suitable remodeling rate in balance with bone formation and desirable clinical manageability. However, none of bone substitute is simultaneously characterized by these features, and currently, the limited remodeling property leads to the excessive waiting time before implantation. Enlightened by woven bone, the transitional tissue that is able to induce osteogenesis during bone healing could be easily remodeled within a short period and depend on the favorable injectability of hydrogel, an injectable woven bone-like hydrogel (IWBLH) was constructed in this study to address the above problems. To mimic the component and hierarchical structure of woven bone, amorphous calcium phosphate (ACP) and mineralized collagen fibril were synthesized and compounded with alginate to form IWBLHs with various ratio. Screened by physiochemical characterization and in vitro biological assays, an optimal IWBLH was selected and further explored in rat model of tooth extraction. Compared with the most widely used bone substitute, we showed that IWBLH could be easily handled to fully fill the tooth socket, perform a comparable function to prevent the alveolar bone resorption, and completely remodeled within 4 weeks. This IWBLH stands as a promising candidate for alveolar ridge preservation (ARP) in future.

show abstract

“…Many different materials have been used as sutures, including metal wires (e.g., gold, silver, and steel), naturally harvested or derived fibers (e.g., silk, linen, and human hair), sheep or goat intestines, and-more recently-synthetic fibers made of non-absorbable (e.g., nylon) and absorbable polymers (e.g., poly(glycolic acid) (PGA) and polydioxanone (PDO)). [1][2][3] In addition to bringing damaged body tissue together and holding it in place for subsequent healing, current trends have also focused on modifying the suture material itself and its structure to make them biologically active. Recent developments in advanced material fabrication processes and modifications have allowed exploration of these new possibilities.…”

Section: Doi: 101002/adma202004733mentioning

confidence: 99%

Biomimicking Antibacterial Opto‐Electro Sensing Sutures Made of Regenerated Silk Proteins

et al. 2020

View full text Add to dashboard Cite

Surgical sutures play an important role across a wide range of medical treatments and a wide variety exist, differing in strength, size, composition, and performance. Recently, increasing interest has been paid to bioactive and electronic sutures made of synthetic polymers, owing to their ability to reduce inflammation as well as medically and/or electronically facilitate wound healing. However, integrating sensing capabilities into bioactive sutures without adversely affecting their mechanical strength, biocompatibility, and/or bioactivity remains challenging. In this work, a set of biomimicking, antibacterial, and sensing sutures based on the regenerated silk fibroin is designed and fabricated. These sensing sutures, inspired by the “core–shell” multilayered structure of natural spider‐silk fibers, are hierarchically structured and heterogeneously functionalized to allow for the integration of multiple, clinically favorable functions into one suture device. These functions included: reducing inflammation and bacterial infection in wound sites, measuring tension of both the tissue and suture, and aiding tissue healing via multi‐modal controlled drug and growth factor release. Critically, these functions are coupled with real‐time optical and electronic monitoring capabilities. This approach provides greater insight into multifunctional sutures with inherent sensing capabilities and offers enormous potential in both therapeutic and diagnostic applications.

show abstract

Multifunctional Fibers to Shape Future Biomedical Devices

Cited by 87 publications

References 97 publications

Smart Microneedles with Porous Polymer Coatings for pH-Responsive Drug Delivery

Smart Microneedles with Porous Polymer Coatings for pH-Responsive Drug Delivery

The Injectable Woven Bone-Like Hydrogel to Perform Alveolar Ridge Preservation With Adapted Remodeling Performance After Tooth Extraction

Biomimicking Antibacterial Opto‐Electro Sensing Sutures Made of Regenerated Silk Proteins

Contact Info

Product

Resources

About