Multifunctional Envelope-Type Mesoporous Silica Nanoparticles for Tumor-Triggered Targeting Drug Delivery

Zhang, Jing; Yuan, Zhefan; Wang, Ya; Chen, Wei‐Hai; Luo, Guo‐Feng; Cheng, Si‐Xue; Zhuo, Ren‐Xi; Zhang, Xian‐Zheng

doi:10.1021/ja312004m

Cited by 483 publications

(347 citation statements)

References 30 publications

(38 reference statements)

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“…164 Similarly, a multifunctional envelope-type mesoporous silica nanoparticle was developed for selective intracellular drug delivery, containing an RGD motif and an MMP-substrate peptide, Pro-Leu-Gly-Val-Arg. 165 Treatment of SCC7, HT29, and 293T cells with this drug-delivery system resulted in increased cell death, with low cytotoxic effects. 165 Taken together, MMPs remain hopeful targets for anticancer therapy in various types of solid and hematological malignancies, in spite of disappointments with earlier regimens.…”

Section: Targeting the Mmp Noncatalytic Domainmentioning

confidence: 94%

“…165 Treatment of SCC7, HT29, and 293T cells with this drug-delivery system resulted in increased cell death, with low cytotoxic effects. 165 Taken together, MMPs remain hopeful targets for anticancer therapy in various types of solid and hematological malignancies, in spite of disappointments with earlier regimens. 166 Therefore, ongoing research continues to explore modern therapeutic approaches combining small molecules and macromolecular inhibitors with novel drug-delivery systems in HNSCCs.…”

Section: Targeting the Mmp Noncatalytic Domainmentioning

confidence: 94%

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Matrix metalloproteinases in head and neck cancer: current perspectives

Gkouveris¹,

Nikitakis²,

Aseervatham³

et al. 2017

MNM

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Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases encoded by 24 distinct genes. Their functions have been implicated in numerous normal and pathologic processes, including uterine involution and organogenesis, inflammation and wound healing, vascular and autoimmune disease progression. Pertinent to this review, the role of MMPs in cancer biology is fairly well researched and documented, and remains a subject of continuing intense investigation. Not only are several MMPs overexpressed in head and neck squamous cell carcinomas (HNSCCs), expression has been correlated with salient tumorigenic hallmarks, such as cell proliferation, angiogenesis, invasion, and metastasis. The utility of changes in the expression profile, as well as various MMP polymorphisms as potential prognostic markers in oral cancers and oral premalignant lesions, have been investigated. Furthermore, the potential therapeutic utility of targeting MMPs in cancer remains attractive, although outcomes in this respect appear so far to be less encouraging with respect to HNSCCs. Because of the disappointing results observed in clinical trials where MMP-targeting regimens for HNSCCs utilized broad-spectrum small MMP catalytic site inhibitors, investigators now envision new strategies for MMP-specific targeting based on the recognition of new noncatalytic MMP domains with distinct functions. This review provides an overview of MMP activities in general and in cancers, and an update of their activities in HNSCC. Specifically, their role in the development and progression of HNSCC and their function as signaling molecules is discussed. Finally, their role as potential prognostic biomarkers and therapeutic targets in HNSCC is revisited.

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Section: Targeting the Mmp Noncatalytic Domainmentioning

confidence: 94%

Section: Targeting the Mmp Noncatalytic Domainmentioning

confidence: 94%

Matrix metalloproteinases in head and neck cancer: current perspectives

Gkouveris¹,

Nikitakis²,

Aseervatham³

et al. 2017

MNM

View full text Add to dashboard Cite

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“…Apart from their mechano-and electrical applications, some applications, such as wave absorbing materials [5][6][7][8][9][10][11], and biomedical applications [12][13][14][15][16][17], have seen rapid developments in recent years. Magnetic nanoparticles play an important role in these functional applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and surface modification of cobalt nanoparticles and electromagnetic property of Co/PPy nanocomposites

et al. 2015

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In this work, cobalt nanoparticles were synthesized by chemical reduction procedure. After the hydrophilic functionalization, Co/polypyrrole (PPy) nanocomposites were prepared by in situ polymerization of pyrrole in aqueous dispersion of Co nanoparticles. The Co/ PPy nanocomposites show good electromagnetic properties with both magnetic loss and dielectric loss to electromagnetic wave. The electromagnetic wave absorbing bandwidth (reflection loss \-10 dB) for Co/PPy (20 wt%) is above 5.5 GHz at a thickness of 2 mm, and with a maximum reflection loss (around -20.02 dB) at 14.77 GHz. This magnetic nanoparticles/conducting polymer nanocomposites are great potential candidates for electromagnetic wave absorbent, because of their wide-absorbing frequency, strong absorption, good compatibility, low density, and controllable absorbing properties.

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“…[19] However, using shielded targeting agents in this context makes EPR [20], [21] effect as solely responsible for nanocarrier accumulation in tumoral tissues. [22] Therefore, the achieved gain regarding lower cross interactions and higher penetration could be counteracted by the lower amount of nanocarriers which reach the diseased zone. Additionally, this approach is hardly adaptable to the direct conjugation with small drugs, due to these therapeutic agents do not present EPR effect, as a consequence of their smaller size.…”

Section: A] *mentioning

confidence: 99%

Double Sequential Encrypted Targeting Sequence: A New Concept for Bone Cancer Treatment

Villaverde

Nairi

Baeza

et al. 2017

Chemistry A European J

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Abstract:The selective transportation of therapeutic agents to tumoral cells is usually achieved by their conjugation with targeting moieties able to recognize these cells. Unfortunately, simple and static targeting systems usually show selectivity lacks. Herein, double sequential encrypted targeting system is proposed as stimuliresponsive targeting analogue for selectivity enhancement. The system is able to recognize diseased bone tissue in first place, and once there, a hidden secondary targeting group is activated by the presence of an enzyme overproduced in the malignant tissue (cathepsin K), triggering the recognition of diseased cells. Transporting the cell targeting agent in a hidden conformation which contains a high selective tissular primary targeting, could avoid not only its binding to similar cell receptors but also the apparition of the binding-site barrier effect, which can enhance the penetration of the therapeutic agent within the affected zone. This strategy could be applied not only to conjugate drugs but also to drug loaded nanocarriers in order to improve the efficiency for bone cancer treatments.

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Multifunctional Envelope-Type Mesoporous Silica Nanoparticles for Tumor-Triggered Targeting Drug Delivery

Cited by 483 publications

References 30 publications

Matrix metalloproteinases in head and neck cancer: current perspectives

Matrix metalloproteinases in head and neck cancer: current perspectives

Synthesis and surface modification of cobalt nanoparticles and electromagnetic property of Co/PPy nanocomposites

Double Sequential Encrypted Targeting Sequence: A New Concept for Bone Cancer Treatment

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