Multifunctional elastomer cardiac patches for preventing left ventricle remodeling after myocardial infarction in vivo

Yao, Yingming; Li, Aoqi; Wang, Shuqin; Lu, Yuwen; Xie, Jieqi; Zhang, Haolan; Zhang, Deteng; Ding, Jie; Wang, Zhaoyi; Tu, Chenxi; Shen, Lishui; Zhuang, Lenan; Zhu, Yang; Gao, Changyou

doi:10.1016/j.biomaterials.2022.121382

Cited by 38 publications

(27 citation statements)

References 54 publications

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“…Revascularization of the ischemic myocardium is very important for cardiac regeneration and functional recovery. Increasing myocardial capillary density is an effective strategy to restore blood and nutrient supply to ischemic myocardial tissue [ 70 ]. Therefore, we assessed therapeutic pro-angiogenic processes in the infarcted area at 4 weeks after MI.…”

Section: Resultsmentioning

confidence: 99%

An injectable conductive hydrogel restores electrical transmission at myocardial infarct site to preserve cardiac function and enhance repair

Zhang

et al. 2023

Bioactive Materials

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Section: Resultsmentioning

confidence: 99%

An injectable conductive hydrogel restores electrical transmission at myocardial infarct site to preserve cardiac function and enhance repair

Zhang

et al. 2023

Bioactive Materials

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“…In continuous or acute ischemia and hypoxia, myocardial infarction (MI) and reperfusion injury (IR), such as myocardial necrosis and atherosclerotic plaque rupture caused by coronary artery disease, both of them will lead to a series of ECM remodeling and fibrosis ( Libby et al, 2019 ; Y. Yao et al, 2022 ). There are generally three stages of myocardial recovery after MI.…”

Section: Pathology Of Myocardial Fibrosismentioning

confidence: 99%

“…The explosive levels of ROS released during the necrotic, as well as cellular contents, stimulate the onset of inflammation and lead to the polarization of macrophages toward M1 (pro-inflammatory type)(Y. Yao et al, 2022 ). In this stage, matrix metalloproteinase (MMP), secreted by inflammatory cells, degrade the natural ECM, and cause ventricular thinning and left ventricular (LV) remodeling ( Carlini et al, 2019 ).…”

Section: Pathology Of Myocardial Fibrosismentioning

confidence: 99%

“…In recent studies, the synthetic peptide Arg-Glu-Asp-Val (REDV) can promote vascular growth and it is easier to use a biological delivery systems to deliver in the form of packaging (Y. Yao et al, 2022 ). Although cytokines act directly on blood vessels, chemokines promote angiogenesis by recruiting stem cells.…”

Section: Biomaterial-based Therapeutic Strategiesmentioning

confidence: 99%

“…( Stater, Sonay, Hart, and Grimm, 2021 ).Implantable materials developed using biomaterials technology, such as heart patches, vascular stents and bone defect fillers, are also partially used in clinical procedures ( Joanne et al, 2016 ; Pattar et al, 2019 ; Sarig et al, 2016 ; Serpooshan et al, 2013 ; Sondermeijer et al, 2018 ; Xie et al, 2022 ; Y. Yao et al, 2022 ). Biomaterials have broad prospects in the medical industry.…”

Section: Introductionmentioning

confidence: 99%

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Multifunctional biomaterial platforms for blocking the fibrosis process and promoting cellular restoring effects in myocardial fibrosis therapy

Xiong

Zheng³

et al. 2022

Front. Bioeng. Biotechnol.

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Myocardial fibrosis is the result of abnormal healing after acute and chronic myocardial damage and is a direct cause of heart failure and cardiac insufficiency. The clinical approach is to preserve cardiac function and inhibit fibrosis through surgery aimed at dredging blood vessels. However, this strategy does not adequately address the deterioration of fibrosis and cardiac function recovery. Therefore, numerous biomaterial platforms have been developed to address the above issues. In this review, we summarize the existing biomaterial delivery and restoring platforms, In addition, we also clarify the therapeutic strategies based on biomaterial platforms, including general strategies to block the fibrosis process and new strategies to promote cellular restoring effects. The development of structures with the ability to block further fibrosis progression as well as to promote cardiomyocytes viability should be the main research interests in myocardial fibrosis, and the reestablishment of structures necessary for normal cardiac function is central to the treatment of myocardial fibrosis. Finally, the future application of biomaterials for myocardial fibrosis is also highlighted.

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Physiologically Responsive Polyurethanes for Tissue Repair and Regeneration

Liu

Wang

et al. 2022

Advanced NanoBiomed Research

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Polyurethanes have been broadly used as biomaterials in tissue repair and regeneration due to their preeminent biocompatibility and mechanical properties. However, traditional polyurethanes are not able to efficiently cope with the complexity of dynamic tissue microenvironments during the process of disease therapy. Physiologically responsive polyurethanes responding or reacting to biological signals or pathological abnormalities can change their physicochemical properties, enabling on‐demand release or intelligently promoting tissue regeneration. So far, the physiologically responsive polyurethanes have gained significant interest for applications in controlled drug delivery systems and tissue engineering in recent years. This review highlights the research advances in the design of the physiological‐responsive polyurethanes and their applications for tissue repair and regeneration, with particular attention to some representative examples such as pH‐, redox‐, temperature‐, and enzyme‐responsive polyurethanes. The key design principles and applications are illustrated in the treatment of retinal detachment, gastric ulcer, wound, myocardial infarction, lung injury, bone defect, and osteoarthritis. The challenges and future perspectives of the physiological‐responsive polyurethanes are finally discussed.

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Multifunctional elastomer cardiac patches for preventing left ventricle remodeling after myocardial infarction in vivo

Cited by 38 publications

References 54 publications

An injectable conductive hydrogel restores electrical transmission at myocardial infarct site to preserve cardiac function and enhance repair

An injectable conductive hydrogel restores electrical transmission at myocardial infarct site to preserve cardiac function and enhance repair

Multifunctional biomaterial platforms for blocking the fibrosis process and promoting cellular restoring effects in myocardial fibrosis therapy

Physiologically Responsive Polyurethanes for Tissue Repair and Regeneration

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