Abstract:Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is mainly prevalent in the older population. Approximately fifty million people are diagnosed with dementia, with AD accounting for 60-70% of these cases. Amyloid beta (Aβ) is considered a pathological hallmark of AD. The shorter Aβ 25 -35 peptide fragments, formed from the amyloidogenic Aβ 1-40 peptide, plays a crucial role in the peptide's neurotoxic activity (Pike et al., 2002). Acetylcholinesterase (AChE) as well as oxida… Show more
Chiral spiropyrazolones were constructed for the first time through Pd-catalyzed asymmetric sequential hydroalkylation of 1,3-enynes. Through substrate control (by exchanging the position of double bond and triple bond of 1,3-enyne...
Chiral spiropyrazolones were constructed for the first time through Pd-catalyzed asymmetric sequential hydroalkylation of 1,3-enynes. Through substrate control (by exchanging the position of double bond and triple bond of 1,3-enyne...
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