Multifunctional DNA dendrimer nanostructures for biomedical applications

Liu, Linan; Han, Lichi; Wu, Qionghui; Sun, Yue; Li, Kehan; Liu, Yao; Liu, Hanghang; Luo, En

doi:10.1039/d1tb00689d

Cited by 19 publications

(13 citation statements)

References 111 publications

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“… 291 To prolong the half-life of drugs, dendrimer-based NPs were chosen but were found to be time-consuming to produce, potentially cytotoxic and non-degradable. 292 When encountering insoluble drugs such as HCPT, cyclodextrins have often been chosen to increase the solubility of the drug, but cyclodextrin-based NPs were found to be easily and rapidly cleared in circulation. 293 Nanogels and hydrogels are favored for their excellent biocompatibility, large surface area and adjustable properties, but also have the problem of being easily cleared.…”

Section: Discussionmentioning

confidence: 99%

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Chen¹,

Wang²,

Wang³

et al. 2022

IJN

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10-Hydroxycamptothecin (HCPT) is a natural plant alkaloid from Camptotheca that shows potent antitumor activity by targeting intracellular topoisomerase I. However, factors such as instability of the lactone ring and insolubility in water have limited the clinical application of this drug. In recent years, unprecedented advances in biomedical nanotechnology have facilitated the development of nano drug delivery systems. It has been found that nanomedicine can significantly improve the stability and water solubility of HCPT. NanoMedicines with different diagnostic and therapeutic functions have been developed to significantly improve the anticancer effect of HCPT. In this paper, we collected reports on HCPT nanomedicines against tumors in the past decade. Based on current research advances, we dissected the current status and limitations of HCPT nanomedicines development and looked forward to future research directions.

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Section: Discussionmentioning

confidence: 99%

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Chen¹,

Wang²,

Wang³

et al. 2022

IJN

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“…Dendrimers are highly ordered, symmetric, branched polymeric molecules. Many reports have shown that dendrimers potentially transfer genes into cells without damaging or deactivating the DNA ( 215 – 217 ). Poly(amidoamine), or PAMAM, is the most popular dendrimer, which used ethylene diamine or ammonium as a core molecule.…”

Section: Different Immunotherapies and Polymeric Systems Applying For...mentioning

confidence: 99%

Polymeric Systems for Cancer Immunotherapy: A Review

Le¹,

Yoon²,

Thambi³

et al. 2022

Front. Immunol.

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Immunotherapy holds enormous promise to create a new outlook of cancer therapy by eliminating tumors via activation of the immune system. In immunotherapy, polymeric systems play a significant role in improving antitumor efficacy and safety profile. Polymeric systems possess many favorable properties, including magnificent biocompatibility and biodegradability, structural and component diversity, easy and controllable fabrication, and high loading capacity for immune-related substances. These properties allow polymeric systems to perform multiple functions in immunotherapy, such as immune stimulants, modifying and activating T cells, delivery system for immune cargos, or as an artificial antigen-presenting cell. Among diverse immunotherapies, immune checkpoint inhibitors, chimeric antigen receptor (CAR) T cell, and oncolytic virus recently have been dramatically investigated for their remarkable success in clinical trials. In this report, we review the monotherapy status of immune checkpoint inhibitors, CAR-T cell, and oncolytic virus, and their current combination strategies with diverse polymeric systems.

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“…Dendrimers can also be synthesized from the outside-in using convergent synthesis techniques (J. W. Lee et al, 2006). In addition to PAMAM, common dendrimers in biomedical and biosensor applications include polylysine (Boyd et al, 2006;Kaminskas et al, 2008Kaminskas et al, , 2009, poly(propyleneimine) (Idris et al, 2020;Scherrenberg et al, 1998), poly(carbosilane) (Rabiee et al, 2020), and DNA (L. Liu et al, 2021;Meng et al, 2014;J. Wang et al, 1998).…”

Section: Brush Dendritic and Hyperbranched Polymersmentioning

confidence: 99%

Branched, dendritic, and hyperbranched polymers in liquid biopsy device design

Poellmann

Rawding

Kim

et al. 2022

WIREs Nanomed Nanobiotechnol

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The development of minimally invasive tests for cancer diagnosis and prognosis will aid in the research of new treatments and improve survival rates. Liquid biopsies seek to derive actionable information from tumor material found in routine blood samples. The relative scarcity of tumor material in this complex mixture makes isolating and detecting cancerous material such as proteins, circulating tumor DNA, exosomes, and whole circulating tumor cells a challenge for device engineers. This review describes the chemistry and applications of branched and hyperbranched to improve the performance of liquid biopsy devices. These polymers can improve the performance of a liquid biopsy through several mechanisms. For example, polymers designed to increase the affinity of capture enhance device sensitivity. On the other hand, polymers designed to increase binding avidity or repel nonspecific adsorption enhance device specificity. Branched and hyperbranched polymers can also be used to amplify the signal from small amounts of detected material. The further development of hyperbranched polymers in liquid biopsy applications will enhance device capabilities and help these critical technologies reach the oncology clinic where they are sorely needed.

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Multifunctional DNA dendrimer nanostructures for biomedical applications

Abstract: DNA nanomaterials have attracted ever-increasing attentions over the past decades attributing to the incomparable programmability and multifunctionality. In particular, DNA dendrimer nanostructures, as major research focus, have been applied in...

Cited by 19 publications

References 111 publications

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Polymeric Systems for Cancer Immunotherapy: A Review

Branched, dendritic, and hyperbranched polymers in liquid biopsy device design

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