Multifunctional Cu₃₉S₂₈ hollow nanopeanuts for in vivo targeted photothermal chemotherapy

Abstract

Actively targeted hollow nanoparticles may play key roles in precise anti-cancer therapy. Here, unique Cu39S28 hollow nanopeanuts (HNPs) were synthesized via a facile one-step method and the formation mechanism was illustrated. The as-synthesized Cu39S28 HNPs exhibit outstanding photothermal conversion efficiency (41.1%) and drug storage capacity (DOX, 99.5 %). At the same time, the DOX drug loading nanocomposites have shown great sensitive response of release to either pH value or near infrared ray (NIR). In particular, the folic acid (FA) can easily conjugate with the synthesized Cu39S28 HNPs without further modification to get a targeted effect. The FA modified Cu39S28 HNPs showed an efficiently targeting effect in vitro and could considerably enhance the tumor-targeting effect more than 10 times in vivo. Moreover, the synthetical hyperthermia and drug release from Cu39S28 HNPs when under 808 nm laser could significantly improve the therapeutic efficacy compared with photothermal or chemotherapy alone both in vitro and in vivo. The histological studies in main organs also proved the well biocompatibility, while the tumor sites were in seriously destruction due to the accumulation of the nanocomposites and the combined photothermal chemo therapy effect. Therefore, the multi-functional nanocomposites is excellent antitumor agents due to their superb therapy effect in breast cancer.

Actively Targeted Deep Tissue Imaging and Photothermal‐Chemo Therapy of Breast Cancer by Antibody‐Functionalized Drug‐Loaded X‐Ray‐Responsive Bismuth Sulfide@Mesoporous Silica Core–Shell Nanoparticles

“…The FITC labeling of the NPs was done following our previous report. [36] Tam-Bi 2 S 3 @mPS-FITC, Bi 2 S 3 @mPS-FITC, or FITC were cocultured with HER-2 positive SKBR-3 cells or HER-2 negative MCF-7 cells for 24 h. The cells were washed three times with PBS, and then photographed using a fluorescence microscope (Olympus, BX51, Japan). For flow cytometry analysis, the same procedures were carried out, and then the cells were collected and analyzed with a BD FACSCalibur flow cytometer (BD, USA).…”

Synergistic Photothermal and Photodynamic Therapy for Effective Implant-Related Bacterial Infection Elimination and Biofilm Disruption Using Cu9S8 Nanoparticles

“…The Cu 9 S 8 NPs were synthesized by a facile one-step wet chemical method by reacting Cu­(NO 3 ) 2, Na 2 S and l -cysteine at a ratio of 1:1:1 for 1.5 h at 90 °C. , The Cu 9 S 8 NPs were then modified with mPEG-SH to improve their biocompatibility. The TEM images (Figure a,b) showed spherical Cu 9 S 8 NPs with a size of 120 nm.…”

“…The Cu 9 S 8 NPs were synthesized according to our previously published procedure with some modifications. , Briefly, 1 mmol of l -cysteine (0.121 g) was dissolved in 50 mL of dd H 2 O and added into 150 mL of 1 mM Cu­(NO 3 ) 2 solution under constant stirring at room temperature (RT) for 30 min. Then, 2 mL of Na 2 S solution (1 mmol, 0.240 g) was added dropwise into the above mixture over 2 min.…”

Environmentally responsive dual-targeting nanotheranostics for overcoming cancer multidrug resistance

“…Recent studies have suggested that nanomedicine offers great promise for eradicating MDR by increasing and tailoring the intracellular delivery of therapeutic agents [6,[16][17][18][19][20][21][22]. Compared to the traditional chemotherapy, nano-based delivery systems make it accessible to co-load chemotherapeutic compounds and chemosensitizing agents, including transporter protein inhibitors or gene-silencing agents, into one nanocarrier [23][24][25][26][27][28][29][30]. With continued elaborate engineering, through chemical modification or physical coating, such nano delivery systems can be tailored to serve a wealth of functions, such as active tumor targeting, environmentally-responsive drug release, and image-guided cancer theranostics [31][32][33].…”