Multifunctional core/satellite polydopamine@Nd3+-sensitized upconversion nanocomposite: A single 808 nm near-infrared light-triggered theranostic platform for in vivo imaging-guided photothermal therapy

Ding, Xing; Liu, Jianhua; Liu, Dapeng; Li, Junqi; Wang, Fan; Li, Leijiao; Wang, Yinghui; Song, Shuyan; Zhang, Hongjie

doi:10.1007/s12274-017-1555-x

Cited by 71 publications

(33 citation statements)

References 44 publications

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“…If similar nanomaterials are used together with the NIR organic dye CyTE-777 or IR-825 as photothermal sensitizer 45 , 46 , concurrent or separate optical excitations at 980 nm on Yb 3+ for up-conversion imaging and at 808 nm on NIR organic dye for PTT could be performed to avoid the use of different modalities for diagnosis and therapy. Note also, attempts to apply single wavelength of light triggered dual PDT/PTT and imaging become increasingly popular 5 , 47 - 53 , including a few nanomaterials such as SWNTs 47 , Gold nanorod containing NIR dye (GNR-dye) 48 , IR780 NIR dye 5 and core/satellite polydopamine@Nd 3+ UCNP 51 .…”

Section: Introductionmentioning

confidence: 99%

Nd³⁺ sensitized core-shell-shell nanocomposites loaded with IR806 dye for photothermal therapy and up-conversion luminescence imaging by a single wavelength NIR light irradiation

Lin¹,

Chen²,

Chang³

2018

Nanotheranostics

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To perform photothermal therapy (PTT) and luminescence imaging by a single wavelength NIR light irradiation, we have designed and prepared a novel nanocomposite incorporating the IR806 photothermal sensitizers (PTS) into the core-shell-shell NaYF4:Yb,Er@ NaYF4:Yb@NaYF4:Yb,Nd up-conversion nanoparticles (UCNPs). Irradiation with the 793 nm near-infrared (NIR) laser, the Nd3+ ions in the UCNPs were sensitized to up-convert energy via Yb3+ to the Er3+ ions to emit visible light at 540 nm and 654 nm, as well as to down-convert energy to the Yb3+ ions to emit NIR light at 980 nm. For luminescence imaging, the 793 nm NIR radiation is more suitable to use for deeper-tissue penetration and to reduce overheating problem due to water absorption as compared to 980 nm radiation. Additionally, the same 793 nm NIR radiation could also excite the IR806 dye for effective PTT. Surface modifications of the UCNPs with mesoporous silica (mSiO2) and polyallylamine (PAH) allow stable loading of IR806 dye and further derivatization with polyethylene glycol-folic acid (PEG-FA) for tumor targeting. Preliminary in vitro studies demonstrated that the final UCNP@mSiO2/IR806@PAH-PEG-FA nanocomposites (UCNC-FAs) could be uptaken by the MDA-MB-231 cancer cells and were “dark” viable, and when irradiated with the 793 nm laser, the MDA-MB-231 cell viability was effectively reduced. This indicated that the UCNC-FAs nanocomposites could be potentially useful for targeted photothermal therapy and up-conversion luminescence imaging by a single wavelength NIR light irradiation.

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Section: Introductionmentioning

confidence: 99%

Nd³⁺ sensitized core-shell-shell nanocomposites loaded with IR806 dye for photothermal therapy and up-conversion luminescence imaging by a single wavelength NIR light irradiation

Lin¹,

Chen²,

Chang³

2018

Nanotheranostics

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“…This method used the redox capacity and strong binding abilities of PDA toward metal ions to generate corresponding noble metal NPs, [ 45 ] metal oxide NPs, [ 46 ] metal sulfide NPs, [ 43 ] and metal nanocomposites. [ 47 ] The noble metal NPs synthesized by conventional methods showed many attractive properties toward catalysis and antibacterial applications. However, their performances on these applications were often hindered by the stability problems that could inevitably weaken or lose their catalytic and antibacterial activities.…”

Section: Fabrication and Characterization Of Mpdamentioning

confidence: 99%

Metal‐Containing Polydopamine Nanomaterials: Catalysis, Energy, and Theranostics

Wang

Zou

et al. 2020

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261

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Polydopamine (PDA) is a major type of artificial melanin material with many interesting properties such as antioxidant activity, free‐radical scavenging, high photothermal conversion efficiency, and strong metal‐ion chelation. The high affinity of PDA to a wide range of metals/metal ions has offered a new class of functional metal‐containing polydopamine (MPDA) nanomaterials with promising functions and extensive applications. Understanding and controlling the metal coordination environment is vital to achieve desirable functions for which such materials can be exploited. MPDA nanomaterials with metal/metal ions as the active functions are reviewed, including their synthesis and metal coordination environment and their applications in catalysis, batteries, solar cells, capacitors, medical imaging, cancer therapy, antifouling, and antibacterial coating. The current trends, limitations, and future directions of this area are also explored.

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“…aspects. 3,4 Until now, various uorescent systems basing on organic uorescent dyes, 5,6 quantum dots (QDs), [7][8][9][10] and upconversion nanoparticles (UCNPs) 11,12 have been rapidly developed for cancer diagnosis. Among them, most uorescent probes could respond to the changes in cancer-related species (e.g., reactive oxygen species, 13 enzymes, 14 and ions 15 ) or unique tumorous microenvironments (e.g., slight acidity, 16 and hypoxia 17,18 ), which achieved off-on uorescence imaging.…”

Section: Introductionmentioning

confidence: 99%

Novel oligopeptide nanoprobe for targeted cancer cell imaging

et al. 2018

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Multifunctional core/satellite polydopamine@Nd3+-sensitized upconversion nanocomposite: A single 808 nm near-infrared light-triggered theranostic platform for in vivo imaging-guided photothermal therapy

Cited by 71 publications

References 44 publications

Nd³⁺ sensitized core-shell-shell nanocomposites loaded with IR806 dye for photothermal therapy and up-conversion luminescence imaging by a single wavelength NIR light irradiation

Nd³⁺ sensitized core-shell-shell nanocomposites loaded with IR806 dye for photothermal therapy and up-conversion luminescence imaging by a single wavelength NIR light irradiation

Metal‐Containing Polydopamine Nanomaterials: Catalysis, Energy, and Theranostics

Novel oligopeptide nanoprobe for targeted cancer cell imaging

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Multifunctional core/satellite polydopamine@Nd3+-sensitized upconversion nanocomposite: A single 808 nm near-infrared light-triggered theranostic platform for in vivo imaging-guided photothermal therapy

Cited by 71 publications

References 44 publications

Nd3+ sensitized core-shell-shell nanocomposites loaded with IR806 dye for photothermal therapy and up-conversion luminescence imaging by a single wavelength NIR light irradiation

Nd3+ sensitized core-shell-shell nanocomposites loaded with IR806 dye for photothermal therapy and up-conversion luminescence imaging by a single wavelength NIR light irradiation

Metal‐Containing Polydopamine Nanomaterials: Catalysis, Energy, and Theranostics

Novel oligopeptide nanoprobe for targeted cancer cell imaging

Contact Info

Product

Resources

About

Nd³⁺ sensitized core-shell-shell nanocomposites loaded with IR806 dye for photothermal therapy and up-conversion luminescence imaging by a single wavelength NIR light irradiation

Nd³⁺ sensitized core-shell-shell nanocomposites loaded with IR806 dye for photothermal therapy and up-conversion luminescence imaging by a single wavelength NIR light irradiation