Multifunctional biosensor constructed by Ag-coating magnetic-assisted unique urchin core porous shell structure for dual SERS enhancement, enrichment, and quantitative detection of multi-components inflammatory markers

Zhou, Xia; Li, Ping; Wu, Xin; Lin, Xiaoling; Zhao, Li; Huang, Haiqiu; Wu, Jia‐Min; Cai, Huaihong; Xu, Meng; Zhou, Haibo; Sun, Ping‐Hua

doi:10.1016/j.bios.2022.114257

Cited by 19 publications

(7 citation statements)

References 36 publications

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“…The most outstanding feature of the microfluidic system is its ability to analyze and manipulate microliters of fluid in channels with diameters of 10–100 μm [ 41 , 42 ]. A porous structured microfluidic system with small thermal mass, high mass transfer efficiency, high specific surface area, good permeability, low relative density and high specific strength can effectively improve the flux rate and sensitivity of the device [ 43 , 44 , 45 , 46 , 47 , 48 , 49 ]. The diversity of porous materials stems from a wide range of preparation methods [ 50 , 51 , 52 , 53 , 54 ].…”

Section: Different Materials and Preparation Methods For Microfluidic...mentioning

confidence: 99%

Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review

et al. 2023

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Microfluidics has recently received more and more attention in applications such as biomedical, chemical and medicine. With the development of microelectronics technology as well as material science in recent years, microfluidic devices have made great progress. Porous structures as a discontinuous medium in which the special flow phenomena of fluids lead to their potential and special applications in microfluidics offer a unique way to develop completely new microfluidic chips. In this article, we firstly introduce the fabrication methods for porous structures of different materials. Then, the physical effects of microfluid flow in porous media and their related physical models are discussed. Finally, the state-of-the-art porous microfluidic chips and their applications in biomedicine are summarized, and we present the current problems and future directions in this field.

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Section: Different Materials and Preparation Methods For Microfluidic...mentioning

confidence: 99%

Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review

et al. 2023

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“…[121][122][123] NPs were also used in the biosensor for the detection of IL-6. [123][124][125][126] For MMP-9 detection, Alekhmimi et al used peptide-magnetic NP conjugates in the biosensor. 127 In addition, inorganic NPs also help for sepsis treatment.…”

Section: How Nano-medicinal Materials Can Help Diagnose and Treat Sep...mentioning

confidence: 99%

How Extracellular Nano-Vesicles Can Play a Role in Sepsis? An Evidence-Based Review of the Literature

Jin,

Sun,

Yang

2023

IJN

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Sepsis is a systemic inflammatory reaction caused by infection. Severe sepsis can lead to multiple organ dysfunction, with a high incidence rate and mortality. The molecular pathogenesis of sepsis is complex and diverse. In recent years, with further study of the role of extracellular vesicles (EVs) in inflammatory diseases, it has been found that EVs play a dual role in the imbalance of inflammatory response in sepsis. Due to the great advantages such as lower toxicity, lower immunogenicity compared with stem cells and better circulation stability, EVs are increasingly used for the diagnosis and treatment of sepsis. The roles of EVs in the pathogenesis, diagnosis and treatment of sepsis were summarized to guide further clinical studies.

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“…Another interesting SERS-based method proposed by Zhou et al [ 94 ] a sandwich structure AgMNPs/IMs/CPs for the detection of Inflammatory Markers (IMs) such as CRP, IL-6 and PCT, was described. Unlike the previous study, Raman Reporters (RaRs) signals were herein enhanced (not those from the analytes).…”

Section: Biosensor As An Alternative Device For Sepsismentioning

confidence: 99%

Emerging Biosensing Technologies towards Early Sepsis Diagnosis and Management

et al. 2022

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Sepsis is defined as a systemic inflammatory dysfunction strictly associated with infectious diseases, which represents an important health issue whose incidence is continuously increasing worldwide. Nowadays, sepsis is considered as one of the main causes of death that mainly affects critically ill patients in clinical settings, with a higher prevalence in low-income countries. Currently, sepsis management still represents an important challenge, since the use of traditional techniques for the diagnosis does not provide a rapid response, which is crucial for an effective infection management. Biosensing systems represent a valid alternative due to their characteristics such as low cost, portability, low response time, ease of use and suitability for point of care/need applications. This review provides an overview of the infectious agents associated with the development of sepsis and the host biomarkers suitable for diagnosis and prognosis. Special focus is given to the new emerging biosensing technologies using electrochemical and optical transduction techniques for sepsis diagnosis and management.

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Multifunctional biosensor constructed by Ag-coating magnetic-assisted unique urchin core porous shell structure for dual SERS enhancement, enrichment, and quantitative detection of multi-components inflammatory markers

Cited by 19 publications

References 36 publications

Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review

Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review

How Extracellular Nano-Vesicles Can Play a Role in Sepsis? An Evidence-Based Review of the Literature

Emerging Biosensing Technologies towards Early Sepsis Diagnosis and Management

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