Multifunctional biophotonic nanostructures inspired by the longtail glasswing butterfly for medical devices

Narasimhan, Vinayak; Siddique, Radwanul Hasan; Lee, Jeong Oen; Kumar, Shailabh; Ndjamen, Blaise; Du, Juan; Hong, Natalie; Sretavan, David W.; Choo, Hyuck

doi:10.1038/s41565-018-0111-5

Cited by 92 publications

(74 citation statements)

References 46 publications

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“…Beginning at approximately 20% of development, bundles of actin filaments start extruding a growing scale extension through a socket cell . By 40% of pupal development, the actin bundles have organized into a highly ordered pattern and direct the deposition of chitin into parallel structures . The resulting scale consists of highly ordered ridges of lamellae connected by crossribs.…”

Section: Introductionmentioning

confidence: 99%

“…5 Wing patterns are made of hundreds of thousands of scales that derive their color from pigments, ultrastructure, or a combination of the two. 6,7 Scale structures interact with light through a variety of mechanisms that have been described from a biophysical perspective, 8 including light-trapping black, [9][10][11] light polarization, 12 high-reflectance, 13 transparency, 14 and color-selective iridescence. [15][16][17][18][19] For instance, the coherent light-scattering features of Morpho butterflies reflect specific wavelengths, producing their characteristic blue iridescence.…”

mentioning

confidence: 99%

“…30,31 By 40% of pupal development, the actin bundles have organized into a highly ordered pattern and direct the deposition of chitin into parallel structures. 14 The resulting scale consists of highly ordered ridges of lamellae connected by crossribs. These crossribs are supported by rods called trabeculae, that interact with the lower lamina and provide scaffolding support to the scale structure.…”

mentioning

confidence: 99%

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Sub‐micrometer insights into the cytoskeletal dynamics and ultrastructural diversity of butterfly wing scales

Day

Hanly

Ren

et al. 2019

Developmental Dynamics

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Background The color patterns that adorn lepidopteran wings are ideal for studying cell type diversity using a phenomics approach. Color patterns are made of chitinous scales that are each the product of a single precursor cell, offering a 2D system where phenotypic diversity can be studied cell by cell, both within and between species. Those scales reveal complex ultrastructures in the sub‐micrometer range that are often connected to a photonic function, including iridescent blues and greens, highly reflective whites, or light‐trapping blacks. Results We found that during scale development, Fascin immunostainings reveal punctate distributions consistent with a role in the control of actin patterning. We quantified the cytoskeleton regularity as well as its relationship to chitin deposition sites, and confirmed a role in the patterning of the ultrastructures of the adults scales. Then, in an attempt to characterize the range and variation in lepidopteran scale ultrastructures, we devised a high‐throughput method to quickly derive multiple morphological measurements from fluorescence images and scanning electron micrographs. We imaged a multicolor eyespot element from the butterfly Vanessa cardui (V. cardui), taking approximately 200 000 individual measurements from 1161 scales. Principal component analyses revealed that scale structural features cluster by color type, and detected the divergence of non‐reflective scales characterized by tighter cross‐rib distances and increased orderedness. Conclusion We developed descriptive methods that advance the potential of butterfly wing scales as a model system for studying how a single cell type can differentiate into a multifaceted spectrum of complex morphologies. Our data suggest that specific color scales undergo a tight regulation of their ultrastructures, and that this involves cytoskeletal dynamics during scale growth.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Sub‐micrometer insights into the cytoskeletal dynamics and ultrastructural diversity of butterfly wing scales

Day

Hanly

Ren

et al. 2019

Developmental Dynamics

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“…We utilized a biomimetic scalable fabrication technique to create large scale nDISC metasurfaces either on a silicon wafer or on a flexible substrate as illustrated in Figure 3a and demonstrated biosensing applications. 30,31 The details of the fabrication are included in the methods section. In brief, we spin-coated two phase-separated polymers, PMMA and polystyrene (PS), in a blend solution of butanone onto a 4' SOI wafer that undergoes a 3-dimensional phase separation in a humid environment and self-assembles into PS nano-islands in a PMMA matrix.…”

Section: Resultsmentioning

confidence: 99%

Aluminum Metasurface with Hybrid Multipolar Plasmons for 1000-Fold Broadband Visible Fluorescence Enhancement and Multiplexed Biosensing

et al. 2019

Self Cite

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Aluminum (Al)-based nanoantennae traditionally suffer from weak plasmonic performance in the visible range, necessitating the application of more expensive noble metal substrates for rapidly expanding biosensing opportunities. We introduce a metasurface comprising Al nanoantennae of nanodisks-in-cavities that generate hybrid multipolar lossless plasmonic modes to strongly enhance local electromagnetic fields and increase the coupled emitter's local density of states throughout the visible regime. This results in highly efficient electromagnetic field confinement in visible wavelengths by these nanoantennae favoring real-world plasmonic applications of Al over other noble metal. Additionally, we demonstrate spontaneous localization and concentration of target molecules at metasurface hotspots, leading to further improved on-chip detection sensitivity and a broadband fluorescence-enhancement factor above 1000 for visible wavelengths with respect to glass chips commonly used in bioassays. Using the metasurface and a multiplexing technique involving three visible wavelengths, we successfully detected three biomarkers, insulin, vascular endothelial growth factor, and thrombin relevant to diabetes, ocular and cardiovascular diseases, respectively, in a single 10-L droplet containing only 1 fmol of each biomarker.

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“…To effectively cure the cutaneous infection by bacteria, the dressing film is enabled to inhibit the aggregation of bacteria and biofilm formation 16. Inspired by the shark skin, which deters marine organisms from attaching and growth,17 we decorated microtopography by imparting adhesion resistance to the biointerface to prevent bacteria aggregating (Figure 1b left).…”

mentioning

confidence: 99%

Thermal‐Disrupting Interface Mitigates Intercellular Cohesion Loss for Accurate Topical Antibacterial Therapy

Berkey

Feliciano

et al. 2020

Advanced Materials

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Bacterial infections remain a leading threat to global health because of the misuse of antibiotics and the rise in drug‐resistant pathogens. Although several strategies such as photothermal therapy and magneto‐thermal therapy can suppress bacterial infections, excessive heat often damages host cells and lengthens the healing time. Here, a localized thermal managing strategy, thermal‐disrupting interface induced mitigation (TRIM), is reported, to minimize intercellular cohesion loss for accurate antibacterial therapy. The TRIM dressing film is composed of alternative microscale arrangement of heat‐responsive hydrogel regions and mechanical support regions, which enables the surface microtopography to have a significant effect on disrupting bacterial colonization upon infrared irradiation. The regulation of the interfacial contact to the attached skin confines the produced heat and minimizes the risk of skin damage during thermoablation. Quantitative mechanobiology studies demonstrate the TRIM dressing film with a critical dimension for surface features plays a critical role in maintaining intercellular cohesion of the epidermis during photothermal therapy. Finally, endowing wound dressing with the TRIM effect via in vivo studies in S. aureus infected mice demonstrates a promising strategy for mitigating the side effects of photothermal therapy against a wide spectrum of bacterial infections, promoting future biointerface design for antibacterial therapy.

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Multifunctional biophotonic nanostructures inspired by the longtail glasswing butterfly for medical devices

Cited by 92 publications

References 46 publications

Sub‐micrometer insights into the cytoskeletal dynamics and ultrastructural diversity of butterfly wing scales

Sub‐micrometer insights into the cytoskeletal dynamics and ultrastructural diversity of butterfly wing scales

Aluminum Metasurface with Hybrid Multipolar Plasmons for 1000-Fold Broadband Visible Fluorescence Enhancement and Multiplexed Biosensing

Thermal‐Disrupting Interface Mitigates Intercellular Cohesion Loss for Accurate Topical Antibacterial Therapy

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