Multifunctional biocompatible coatings on magnetic nanoparticles

Bychkova, A. V.; Sorokina, O. N.; Rosenfeld, M. A.; Kovarski, Alexander L.

doi:10.1070/rc2012v081n11abeh004280

Cited by 54 publications

(28 citation statements)

References 232 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…That is why such studies receive considerable attention [Bychkova [1], Gusev and Rempel [2], and Beloglazkina et al [3]]. In connection with a wide area of nanocomposite applications in modern technologies and material science, methods are developing for their synthesis [Olenin and Lisichkin [4]].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Behavior and Electrodeposition of Nanostructured Rhodium from Low-Temperature Carbamide and Acetamide Containing Melts

Kochetova¹,

Savchuk²,

Shakhnin³

et al. 2017

Nanoscale Res Lett

View full text Add to dashboard Cite

The electrochemical behavior of rhodium at low-temperature carbamide-chloride and acetamide-chloride melts was investigated. It was found that, during rhodium anodic dissolution in carbamide and acetamide containing chloride melts, mixed complexes [Rh(NH3)4Cl2]+ of quasi-octahedral symmetry D4h are produced. The composition and structure of nascent complex ions have been studied. During electrochemical reduction of [Rh(NH3)4Cl2]+ complexes, the synthesis of Rh nanoparticles, as well as Fe, Cu, and Mo nanocoatings, were realized.

show abstract

Section: Introductionmentioning

confidence: 99%

Electrochemical Behavior and Electrodeposition of Nanostructured Rhodium from Low-Temperature Carbamide and Acetamide Containing Melts

Kochetova¹,

Savchuk²,

Shakhnin³

et al. 2017

Nanoscale Res Lett

View full text Add to dashboard Cite

show abstract

“…Biofunctional magnetic nanoparticles have yet to be met with several challenges like a robust surface chemistry to attach bioactive molecules without laborious synthetic efforts, precise control of the numbers and orientations of the molecules on the surfaces of magnetic nanoparticles and need of multifunctional and (perhaps) multimodal magnetic nanoparticles for biological applications. Multifunctional coatings protect the surface of nanoparticles, stabilize the suspension, maintain hemo-compatibility and inhibit platelet aggregation [7]. Moreover, magnetic nanoparticles are biodegradable, which act as a promising carrier system for brain delivery of exogenous molecules [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Technique to optimize magnetic response of gelatin coated magnetic nanoparticles

Parikh

Parekh

2015

J Mater Sci: Mater Med

View full text Add to dashboard Cite

The paper describes the results of optimization of magnetic response for highly stable bio-functionalize magnetic nanoparticles dispersion. Concentration of gelatin during in situ co-precipitation synthesis was varied from 8, 23 and 48 mg/mL to optimize magnetic properties. This variation results in a change in crystallite size from 10.3 to 7.8 ± 0.1 nm. TEM measurement of G3 sample shows highly crystalline spherical nanoparticles with a mean diameter of 7.2 ± 0.2 nm and diameter distribution (σ) of 0.27. FTIR spectra shows a shift of 22 cm(-1) at C=O stretching with absence of N-H stretching confirming the chemical binding of gelatin on magnetic nanoparticles. The concept of lone pair electron of the amide group explains the mechanism of binding. TGA shows 32.8-25.2% weight loss at 350 °C temperature substantiating decomposition of chemically bind gelatin. The magnetic response shows that for 8 mg/mL concentration of gelatin, the initial susceptibility and saturation magnetization is the maximum. The cytotoxicity of G3 sample was assessed in Normal Rat Kidney Epithelial Cells (NRK Line) by MTT assay. Results show an increase in viability for all concentrations, the indicative probability of a stimulating action of these particles in the nontoxic range. This shows the potential of this technique for biological applications as the coated particles are (i) superparamagnetic (ii) highly stable in physiological media (iii) possibility of attaching other drug with free functional group of gelatin and (iv) non-toxic.

show abstract

“…The creation of functional coatings capable of "aiming" the particles to biological targets and possessing therapeu tic effects makes possible efficient application of MNPs for solving biomedical problems [6]. The com position and properties of a coating govern the charac ter of the interaction between nanosystems and a bio logical medium and, hence, their efficiency.…”

Section: Introductionmentioning

confidence: 99%

“…At present, a number of requirements, such as biocompat ibility, prevention of nanoparticle aggregation in a dis persion, and stability to desorption upon the contact with biological objects, are imposed on the coatings. Stability is insured by covalent fixing of the coatings on nanoparticle surface [6]. Coatings based on natural macromolecules, including proteins, seem to be most promising for biomedicine.…”

Section: Introductionmentioning

confidence: 99%

Study of protein coatings cross-linked via the free-radical mechanism on magnetic nanoparticles by the method of spectral and fluorescent probes

et al. 2014

View full text Add to dashboard Cite

2) interaction between two tyrosyl radicals: P 1 tyr • + P 2 tyr • → P 1 tyr-tyrP 2 , Abstract-Magnetite nanoparticles have been obtained with stable coatings formed from bovine and human serum albumins. The coatings are fixed by free radical cross linking of the proteins with the use of their abil ity to form interchain covalent bonds under the action of free radicals, which are generated with participation of transition metals present on nanoparticle surface. The method of spectral and fluorescent probes has been employed for the first time to describe the properties of coatings with the use of various dyes. It has been shown that, when studying the adsorption and free radical cross linking of proteins on nanoparticles, it is reasonable to use polymethine and squarylium dyes for estimating the functional properties of the proteins forming the coatings. It has been found that as many as 50% of molecules forming an albumin coating cross linked via the free radical mechanism retain their capability of bonding to a fluorescent dye. It has been con cluded that the proteins occurring in the structure of the coatings retain their functional properties.

show abstract

Multifunctional biocompatible coatings on magnetic nanoparticles

Cited by 54 publications

References 232 publications

Electrochemical Behavior and Electrodeposition of Nanostructured Rhodium from Low-Temperature Carbamide and Acetamide Containing Melts

Electrochemical Behavior and Electrodeposition of Nanostructured Rhodium from Low-Temperature Carbamide and Acetamide Containing Melts

Technique to optimize magnetic response of gelatin coated magnetic nanoparticles

Study of protein coatings cross-linked via the free-radical mechanism on magnetic nanoparticles by the method of spectral and fluorescent probes

Contact Info

Product

Resources

About