Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self‐Assembly

Abstract

There is a real need for new antibiotics against self‐evolving bacteria. One option is to use biofriendly broad‐spectrum and mechanically tunable antimicrobial hydrogels that can combat multidrug‐resistant microbes. Whilst appealing, there are currently limited options. Herein, broad‐spectrum antimicrobial biometallohydrogels based on the self‐assembly and local mineralization of Ag+‐coordinated Fmoc‐amino acids are reported. Such biometallohydrogels have the advantages of localized delivery and sustained release, reduced drug dosage and toxicity yet improved bioavailability, prolonged drug effect, and tunable mechanical strength. Furthermore, they can directly interact with the cell walls and membrane, resulting in the detachment of the plasma membrane and leakage of the cytoplasm. This leads to cell death, triggering a significant antibacterial effect against both Gram‐negative (Escherichia coli) and Gram‐positive (Staphylococcus aureus) bacteria in cells and mice. This study paves the way for developing a multifunctional integration platform based on simple biomolecules coordinated self‐assembly toward a broad range of biomedical applications.

Self-assembled functional components-doped conductive polypyrrole composite hydrogels with enhanced electrochemical performances

“…TG is a test used to study the thermal stability and composition of composite hydrogels. [22][23][24][25] In order to further study the thermal stability of composite hydrogels, 26 thermogravimetric analyses was used. As shown in Fig.…”

Fabrication of CS/GA/RGO/Pd composite hydrogels for highly efficient catalytic reduction of organic pollutants

“…Moreover, the raw materials and preparation process of CS/GA/RGO/Pd hydrogel are green, pollution-free and environmentally friendly. [68][69][70][71][72][73][74] Aer seven catalytic cycles, Fig. 8 shows that the catalytic efficiency of CS/GA/RGO/Pd composite hydrogel for the NaBH 4 and 4-NP mixture solution.…”

Surface Modification by Nano-Structures Reduces Viable Bacterial Biofilm in Aerobic and Anaerobic Environments

“…Molecular self-assembly has attracted extensive interest in the construction of antimicrobial and antifouling agents [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. Self-assembly is a spontaneous process in which the molecular organization of diverse building blocks, including nucleic acids, peptides, proteins and lipids, organize into well-ordered structures at the nano-scale [ 25 , 26 , 27 , 28 ].…”

“…The modification of amino acids can provide the assemblies with various properties, including antibacterial traits. Recently, Song et al developed biometallohydrogels based on Ag + -coordinated Fmoc-amino acids self-assembly (Fmoc-l-serine, Fmoc-l-aspartic acid, Fmoc-l-leucine, Fmoc-l-proline, Fmoc-glycine) [ 24 ]. These metallohydrogels have been shown to have a significant antibacterial effect against both Gram-negative ( Escherichia coli ) and Gram-positive ( Staphylococcus aureus ) bacteria in cells and mice by their interaction with the cell walls and membrane, resulting in the detachment of the plasma membrane and leakage of the cytoplasm [ 24 ].…”

“…Recently, Song et al developed biometallohydrogels based on Ag + -coordinated Fmoc-amino acids self-assembly (Fmoc-l-serine, Fmoc-l-aspartic acid, Fmoc-l-leucine, Fmoc-l-proline, Fmoc-glycine) [ 24 ]. These metallohydrogels have been shown to have a significant antibacterial effect against both Gram-negative ( Escherichia coli ) and Gram-positive ( Staphylococcus aureus ) bacteria in cells and mice by their interaction with the cell walls and membrane, resulting in the detachment of the plasma membrane and leakage of the cytoplasm [ 24 ]. In another study, Nilsson and coworkers designed the Fluorenylmethoxycarbonyl (Fmoc)-pentafluoro-phenylalanine (Fmoc-F 5 -Phe) [ 73 ], which was later studied for its antibacterial properties [ 74 ].…”