Multifunctional antibiotics-free hydrogel dressings with self-regulated nitric oxide-releasing kinetics for improving open wound healing

Abstract

Healing of large open wounds remains a major challenge in the clinics due to the high risk of bacterial infection and slow healing rates, while excessive use of antibiotics would...

Effect of Gelatin-Based Hemostats on Fibroblasts and Relevant Growth Factors in Wound Healing

“…In recent studies, gelatin is widely used in wound dressings, either solely or in combination with different materials and/or chemical reagents (e.g., nitric oxide, silver, iron-containing nanozymes releasing hydroxyl radicals) resulting in positive effects on wound healing [ 36 , 37 , 38 ]. This is supported by in vitro studies, like an inflammatory model with gelatin/alginate-based microspheres that positively affected cytokines including bFGF and VEGF that play a central role in wound healing [ 39 ].…”

Multifunctional nanofibrous mats: toward antibacterial and anti-inflammatory applications, and visual bacterial diagnosis

“…1–3 Without proper management, almost all cutaneous wounds are susceptible to pathogenic bacterial invasion, which may lead to more severe complications, such as bacteremia, septicemia, and even death of the patient. 4–6 Moreover, to defend against the attack of invading pathogenic bacteria and remove dead tissue, the immune system activates the inflammatory response locally. 7 An appropriate inflammatory response is conducive to tissue regeneration, while persistent inflammation is detrimental and may lead to the deregulated differentiation and activation of keratinocytes, ultimately impeding the process of wound healing.…”