Multifunctional alginate nanoparticles containing nitric oxide donor and silver nanoparticles for biomedical applications

H2S- and NO-releasing gasotransmitter platform: A crosstalk signaling pathway in the treatment of acute kidney injury

“…It has already been reported that NO donors encapsulated in polymeric and metallic nanoparticles present slow and sustained release. Alginate nanoparticles containing S-nitroso-mercaptosuccinic acid promoted sustained NO release for 12 h, which improved antibacterial applications [ 107 ]. Similarly, GSNO encapsulated in chitosan nanoparticles also evidenced sustained release through Fickian-diffusion and reached a plateau after 4 monitoring hours [ 108 ].…”

Polysaccharide nanoparticles: from fabrication to applications

“…An alginate-based system for the delivery of NO and Ag NPs was described by Seabra and coworkers. 226 Alginate NPs were synthesised via gelation with Ca 2+ and a precipitation. Furthermore, Ag NPs synthesised from AgNO 3 and tea extract and mercaptosuccinic acid (a NO acceptor) were encapsulated into the alginate NPs.…”

Nitric oxide (NO) and nanoparticles – Potential small tools for the war against COVID-19 and other human coronavirus infections

“…On the other hand, the encapsulation of NO donors in polymeric nanoparticles is a promising alternative. The encapsulation of AgNPs and S-nitroso-mercaptosuccinic acid (S-nitroso-MSA) in alginate nanoparticles promoted sustained release of NO and a potent antibacterial effect against S. aureus, E. coli and Staphylococcus mutans with low cytotoxicity to non-tumoral cells ( Urzedo et al, 2020 ). The effectiveness of this strategy is not limited to antibacterial applications: the encapsulation of NO donors in chitosan nanoparticles demonstrated important results against leishmaniasis, a parasitic disease ( Cabral et al, 2019 ).…”