Multifunctional active ingredient-based delivery systems for skincare formulations: A review

Kouassi, Marie-Carole; Grisel, Michel; Gore, Ecaterina

doi:10.1016/j.colsurfb.2022.112676

Cited by 22 publications

(18 citation statements)

References 146 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, although pores were seen in all cream 1, cream 5, and cream 6, it was homogeneously dispersed in the emulsion. In addition, it was seen that cream 2, cream 3, and cream 4 were connected to each other with tighter bonds compared to other cream samples (Figure ) and the results were compatible with literature. − …”

Section: Resultssupporting

confidence: 88%

Fabrication and Evaluation of Poly(2-hydroxyethyl methacrylate)/Eudragit L-100 Hydrogels with Fusidic Acid to Promote Eczema Treatment

Çınar Koyuncu,

Acaralı

2023

ACS Omega

View full text Add to dashboard Cite

In this study, hydrogels containing 2-hydroxyethyl methacrylate (HEMA), Eudragit L-100, and fusidic acid in different compositions were prepared with the confinement method by using ammonium persulfate (APS) as a chemical initiator and ethylene glycol dimethacrylate (EGDMA) as a cross-linker to determine the most suitable formulation for use in eczema treatment. Fusidic acid (FA)-confined pHEMA/Eudragit L-100 in synthesis of the hydrogel was used with the Taguchi method, and the optimum synthesis conditions were determined. The swelling percentages of the hydrogels were calculated in different pH environments and distilled water. Also, the cream formulations developed and contained in chitosan and HEMA-based polymers were synthesized. Viscosity and pH values changed between 30,000 and 100,000 cP and between 5 and 6 for different cream formulations with various conditions, respectively. Also, swelling percentages of hydrogels were between 20 and 40. Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) analyses were performed to characterize the hydrogel structure and the cream formulations. In addition, the stability of the formulations to 28 days and the changes in parameters such as appearance, centrifugation, pH, relative density, viscosity, spreading were evaluated, comparatively.

show abstract

Section: Resultssupporting

confidence: 88%

Fabrication and Evaluation of Poly(2-hydroxyethyl methacrylate)/Eudragit L-100 Hydrogels with Fusidic Acid to Promote Eczema Treatment

Çınar Koyuncu,

Acaralı

2023

ACS Omega

View full text Add to dashboard Cite

show abstract

“…In 2021, the global Italian cosmetic sector revenue exceeded 11.8 billion EUR; i.e., it increased by 9.9% compared with 2020, according to Cosmetic Study Center of Italy. A similar growing trend can be recorded in Europe and in the world, with skin-care products being at the top of the rankings [ 1 ]. However, the large use of cosmetics and personal care products is feeding environmental concerns due to presence of solid plastic particles that are synthetic and constituted of poorly biodegradable compounds [ 2 , 3 , 4 , 5 ].…”

Section: Introductionsupporting

confidence: 58%

Salicylic Acid Co-Precipitation with Alginate via Supercritical Atomization for Cosmetic Applications

Baldino

Reverchon

2022

Materials

View full text Add to dashboard Cite

Alginate-based microparticles were produced via supercritical assisted atomization (SAA) with the aim of obtaining a biocompatible and low-cost carrier for the delivery of active compounds in cosmetic applications. Salicylic acid was selected as an active model compound, and it was co-precipitated with alginate via SAA, operating at 82 bar and 80 °C. In particular, the drug-to-polymer weight ratio was fixed at 1/4, whereas polymer concentration was varied from 5 to 20 mg/mL in the starting aqueous solution. Operating in this way, alginate-salicylic acid microparticles were characterized by a mean diameter of 0.72 ± 0.25 µm, and the active compound became amorphous after processing. A salicylic acid encapsulation efficiency close to 100% was reached, and the drug release time from the biopolymeric microparticles was prolonged up to nine times with respect to untreated salicylic acid powder.

show abstract

“…Cosmetic delivery technology plays a crucial role in improving the efficacy of skincare and makeup products, ensuring that the active components reach the target areas for better results. − For example, vitamin C is a popular skincare ingredient, but it is highly unstable. One of the cosmetic delivery technologies for vitamin C uses stabilized forms of vitamin C and optimized formulations to ensure it penetrates the skin’s surface layers, reaching the deeper dermal layers where it can provide antioxidant protection and boost collagen production. , Another example is advanced emulsion and lipid-based delivery systems used in antiaging creams to improve the stability of ingredients like retinol.…”

Section: Introductionmentioning

confidence: 99%

Developing Plant Exosomes as an Advanced Delivery System for Cosmetic Peptide

Hou,

Wei,

Geng

et al. 2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Peptides are a promising skincare ingredient, but due to their inherent instability and the barrier function of the skin's surface, they often have limited skin absorption and penetration, which can significantly hinder their skincare benefits. To address this, a novel technique called NanoGlow has been introduced for encapsulating peptide-based cosmetic raw materials into engineered nanosized plant-derived exosomes (pExo) to achieve the goal of a healthier and more radiant skin state. In this approach, pExo served as carriers for cosmetic peptides across the intact skin barrier, enhancing their biological effectiveness in skin beauty. The NanoGlow strategy combines chemical activation and physical proencapsulation, boasting a high success rate and straightforward and stable operation, making it suitable for large-scale production. Comprehensive analysis using in vitro cellular absorption and skin penetration models has demonstrated that the nanosized pExo carriers significantly improve peptide penetration into the skin compared to free peptides. Furthermore, in vivo tissue slice studies have shown that pExo carriers efficiently deliver acetyl hexapeptide-8 to the skin's dermis, surpassing the performance of free peptides. Cosmetic skincare effect analysis has also indicated that pExo-loaded cosmetic peptides deliver superior results. Therefore, the NanoGlow technique harnesses the natural size and properties of pExo to maximize the bioavailability of cosmetic peptides, holding great promise for developing advanced peptide delivery systems in both the cosmetic and medical drug industries.

show abstract

Multifunctional active ingredient-based delivery systems for skincare formulations: A review

Cited by 22 publications

References 146 publications

Fabrication and Evaluation of Poly(2-hydroxyethyl methacrylate)/Eudragit L-100 Hydrogels with Fusidic Acid to Promote Eczema Treatment

Fabrication and Evaluation of Poly(2-hydroxyethyl methacrylate)/Eudragit L-100 Hydrogels with Fusidic Acid to Promote Eczema Treatment

Salicylic Acid Co-Precipitation with Alginate via Supercritical Atomization for Cosmetic Applications

Developing Plant Exosomes as an Advanced Delivery System for Cosmetic Peptide

Contact Info

Product

Resources

About