Multifunctional 3D-printed scaffolds eradiate orthotopic osteosarcoma and promote osteogenesis via microwave thermo-chemotherapy combined with immunotherapy

Smart stimuli-responsive strategies for titanium implant functionalization in bone regeneration and therapeutics

“…Besides NIR light and pH-responsiveness, ZIF-8 was reported recently to augment microwave-induced hyperthermia therapy. 196 In this study, ZIF-8 nanoparticles were integrated on 3D-printed titanium scaffolds as drug carriers to eradiate osteosarcoma and promote osteogenesis via the synergy of microwave thermo-chemotherapy and immunotherapy. Another study combining pH and NIR light-responsive strategies was reported earlier, in which polydopamine-ferrocene (PDA-Fc) was used to functionalize TiO 2 nanorods for implant-related bacterial infection treatment.…”

A new era in cancer treatment: harnessing ZIF-8 nanoparticles for PD-1 inhibitor delivery

“…5). 123 The combination of IM@Z and NIR laser irradiation, along with PD-L1 siRNA, promotes immune responses both in vitro and in vivo. In vitro, it enhanced the maturation of DCs, proliferation of CD8 + T cells, and production of proinflammatory cytokines.…”

“…This study underscores the potential of this innovative combination strategy, offering a pathway toward improved cancer immunotherapy outcomes. 123 Another study investigated the use of microRNA (miRNA) for cancer treatment, with a focus on improving miRNA delivery and targeting within tumors. ZIF-8 was used as a carrier for miRNA, and the process involved mixing zinc nitrate hexahydrate and 2-methylimidazole in an aqueous solution at pH 8, facilitating the binding of pre-miR-34a.…”

“…This study underscores the potential of this innovative combination strategy, offering a pathway toward improved cancer immunotherapy outcomes. 123…”

Microwave-Responsive Edge-Oxidized Graphene for Imaging-Guided Neoadjuvant Thermal Immunotherapy via Promoting Immunogenic Cell Death and Redressing Hypoxia

“…The rapid advancements in nanomedicine have expanded the avenue of tumor diagnosis and treatment. , Well-designed nanomaterials can selectively accumulate and retain in tumors and enable tumor-specific imaging and precisely controlled thermal therapy. , Regarding the combination of nanomediated thermal therapy with immunotherapy, while promising results have been observed after surgery or other treatments, the effectiveness of this approach in neoadjuvant immunotherapy remains unknown. − Furthermore, the future clinical application of nanomaterials-based thermal immunotherapy faces several challenges. First, the existing studies have mainly focused on photothermal imaging and therapy, , facing the problem of the shallow penetration depth due to light scattering and absorption.…”