Multifold Post‐Modification of Macrocycles and Cages by Isocyanate‐Induced Azadefluorination Cyclisation
Tobias Pausch,
Tim David,
Tom Fleck‐Kunde
et al.
Abstract:We present the multiple post‐modification of organic macrocycles and cages, introducing functional groups into two‐ and three‐dimensional supramolecular scaffolds bearing fluorine substituents, which opens up new possibilities in multi‐step supramolecular chemistry employing the vast chemical space of readily available isocyanates. The mechanism and scope of the reaction that proceeds after isocyanate addition to the benzylamine motif via an azadefluorination cyclisation (ADFC) were investigated using DFT calc… Show more
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