Multifocality in Sporadic Medullary Thyroid Carcinoma: An International Multicenter Study

Essig, Garth; Porter, Kyle; Schneider, David; Arpaia, Debora; Lindsey, Susan C.; Busonero, Giulia; Fineberg, Daniel; Fruci, Barbara; Boelaert, Kristien; Smit, Johannes W. A.; Meijer, Johannes Arnoldus Anthonius; Duntas, Leonidas H.; Sharma, Neil; Costante, Giuseppe; Filetti, Sébastiano; Sippel, Rebecca S.; Biondi, Bernadette; Topliss, Duncan J.; Pacini, Furio; Maciel, Rui M. B.; Walz, Patrick C.; Kloos, Richard T.

doi:10.1089/thy.2016.0255

Cited by 42 publications

(24 citation statements)

References 44 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diagnosis of MTC prior to surgery is important. MTC can be multifocal or bilateral, 34,35 and metastasis can occur early to locoregional lymph nodes 21,36 . As such, TT with central nodal dissection is required for patients with MTC 29 .…”

Section: Discussionmentioning

confidence: 99%

Thyroid cancer histological subtypes based on tumor size: National perspective

et al. 2020

View full text Add to dashboard Cite

Background Thyroid tumor size is an important prognostic factor. The aim of this study is to examine the histological subtypes and management of thyroid cancer based on tumor size (≤4 cm vs >4 cm). Methods Retrospective cohort study utilizing the National Cancer Database, 2004‐2014. Results A total of 152 387 patients were included, 13 614 (8.9%) of whom had a tumor size >4 cm. Histological subtypes of tumors >4 cm were: 69.6% papillary thyroid carcinoma, 17.5% FTC, 7.9% HCC, and 2.8% medullary thyroid carcinoma (MTC). High‐volume hospitals for thyroid surgery were less likely to perform two‐stage thyroidectomy, particularly for tumors ≤4 cm. Low‐volume hospitals had a higher risk of staged thyroidectomy for MTC ≤4 cm (19.8%) compared with high‐volume hospitals (8.7%) (P < .001). Conclusions This study describes the prevalence of thyroid cancer subtypes. In the era of a conservative approach to differentiated thyroid carcinoma, there could be a potential increase in the risk of staged thyroidectomy.

show abstract

Section: Discussionmentioning

confidence: 99%

Thyroid cancer histological subtypes based on tumor size: National perspective

et al. 2020

View full text Add to dashboard Cite

show abstract

“…MTC‐only syndrome is very similar to sporadic MTC, as it arises at an older age, i.e. in the fifth or sixth decade, does not involve other endocrine organs, and is associated with a more favourable prognosis …”

Section: Mtcmentioning

confidence: 99%

Hereditary and familial thyroid tumours

Guilmette

Nosé

2017

Histopathology

View full text Add to dashboard Cite

The worldwide incidence of thyroid malignancies has been increasing rapidly. Sensitive imaging modalities and early detection of thyroid lesions have made thyroid cancers the most rapidly increasing cancers in the USA in 2017 (SEER Cancer Facts, 2017). Clinical awareness of potential risk factors, such as inherited thyroid cancers, has allowed earlier recognition of more vulnerable population clusters. Hereditary thyroid neoplasms arising from calcitonin‐producing C cells are known as familial medullary thyroid carcinomas (FMTCs), and include well‐documented syndromes such as multiple endocrine neoplasia IIA or IIB, and pure familial medullary thyroid carcinoma syndrome. Familial thyroid cancers arising from follicular cells are referred to as familial non‐medullary thyroid carcinoma (FNMTC), or familial follicular cell‐derived carcinoma. Clinicopathological correlations have resulted in the further subclassification of FNMTCs into two groups. Among the first group are found syndromes characterised by a predominance of non‐thyroidal tumours, including familial adenomatous polyposis, Cowden syndrome, Werner syndrome, Carney complex, and Pendred syndrome. The second group encompasses a spectrum of familial syndromes characterised by a predominance of non‐medullary thyroid tumours, such as pure familial papillary thyroid carcinoma with or without oxyphilia, familial papillary thyroid carcinoma with papillary renal cell carcinoma, and familial papillary carcinoma with multinodular goitre. Most familial thyroid cancers have been described as being more aggressive than sporadic thyroid cancers, with a predisposition for lymph node metastasis, extrathyroidal invasion, and a younger age of onset. The distinct thyroid pathology in some of these syndromes should alert the pathologist to a possible familial cancer syndrome.

show abstract

“…(7), in the present study, we noted no direct clinical benefit to extending the RET germline analysis beyond the hot-spot regions in patients with sporadic MTC with multifocality (22%) since the analysis did not identify any mutations in other exons. Therefore, these cases were true sporadic cases of MTC with multifocal tumors, which had been observed in a recent study (34).…”

Section: Discussionmentioning

confidence: 58%

A pioneering RET genetic screening study in the State of Ceará, Brazil, evaluating patients with medullary thyroid cancer and at-risk relatives: experience with 247 individuals

Martins-Costa¹,

Lindsey²,

Cunha³

et al. 2018

Archives of Endocrinology and Metabolism

Self Cite

View full text Add to dashboard Cite

Objective: Initial diagnosis of medullary thyroid carcinoma (MTC) is frequently associated with advanced stages and a poor prognosis. Thus, the need for earlier diagnoses and detection in relatives at risk for the disease has led to increased use of RET genetic screening. Subjects and methods: We performed RET screening in 247 subjects who were referred to the Brazilian Research Consortium for Multiple Endocrine Neoplasia (BRASMEN) Center in the State of Ceará. Direct genetic sequencing was used to analyze exons 8, 10, 11, and 13-16 in MTC index cases and specific exons in at risk relatives. Afterward, clinical follow-up was offered to all the patients with MTC and their affected relatives. Results: RET screening was performed in 60 MTC index patients and 187 at-risk family members. At the initial clinical assessment of the index patients, 54 (90%) were diagnosed with apparently sporadic disease and 6 (10%) diagnosed with hereditary disease. After RET screening, we found that 31 (52%) index patients had sporadic disease, and 29 (48%) had hereditary disease. Regarding at-risk relatives, 73/187 were mutation carriers. Mutations in RET codon 804 and the rare p.M918V mutation were the most prevalent. Conclusions: Performing RET screening in Ceará allowed us to identify a different mutation profile in this region compared with other areas. RET screening also enabled the diagnosis of a significant number of hereditary MTC patients who were initially classified as sporadic disease patients and benefited their relatives, who were unaware of the risks and the consequences of bearing a RET mutation.

show abstract

Multifocality in Sporadic Medullary Thyroid Carcinoma: An International Multicenter Study

Cited by 42 publications

References 44 publications

Thyroid cancer histological subtypes based on tumor size: National perspective

Thyroid cancer histological subtypes based on tumor size: National perspective

Hereditary and familial thyroid tumours

A pioneering RET genetic screening study in the State of Ceará, Brazil, evaluating patients with medullary thyroid cancer and at-risk relatives: experience with 247 individuals

Contact Info

Product

Resources

About