Multifocality and Prostate Cancer Detection by Multiparametric Magnetic Resonance Imaging: Correlation with Whole-mount Histopathology

Correlation of Intraprostatic Tumor Extent with 68Ga-PSMA Distribution in Patients with Prostate Cancer

“…However, tumors with a diameter smaller than 1 cm were missed by multiparametric MRI in most cases, even in some cases of high-grade lesions. Lesions with a Gleason score of 6 were missed in 80% of cases regardless of the diameter of the lesions (19).…”

A fully automatic computer aided diagnosis system for peripheral zone prostate cancer detection using multi-parametric magnetic resonance imaging

“…The latter approach has an important limitation as no information is available on regions annotated as normal by the radiologist that could actually harbour PCa. Indeed, in a recent paper Le et al [35] showed that radiologists can miss up to 40% of clinically significant PCas. Conversely, using the whole-mount sections as histologic reference standard provides more accurate label information for training a CAD system [2], as it assesses the ground truth for both PCa extent, grade, and disease infiltration [36].…”

Prostate-Specific Membrane Antigen–Targeted Radiohalogenated PET and Therapeutic Agents for Prostate Cancer

“…However, those modalities possess significant limitations (5,6). Conventional imaging has not adequately addressed a variety of important clinical issues, including pretherapy risk stratification, reliable pretherapy staging of patients at risk for pelvic lymph node metastases or systemic disease, and the detection of biochemical recurrence at low PSA levels in patients previously treated for PC with curative intent.…”