Multifocal VEP assessment of optic neuritis evolution

Alshowaeir, Daniah; Yannikas, Con; Garrick, R.; Walt, Anneke van der; Graham, Stuart L.; Fraser, Clare L.; Klistorner, Alexander

doi:10.1016/j.clinph.2014.11.010

Cited by 31 publications

(25 citation statements)

References 25 publications

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“…Prolongation of P100 latency, assessed by mfVEPs, predicted RNFL thickness loss as early as 3 and as late as 12 months after the first episode of acute unilateral optic neuritis in a group of relapsing-remitting MS, CIS and isolated optic neuritis 11. VEPs also correlate with early microstructural white matter changes in the frontoparietal cortex, corpus callosum and optic nerve as detected by fractional anisotropy 14.…”

Section: Visual Evoked Potentialsmentioning

confidence: 93%

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Clinical evoked potentials in neurology: a review of techniques and indications

Lascano

Lalive

Hardmeier

et al. 2017

J Neurol Neurosurg Psychiatry

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Evoked potentials (EPs) are a powerful and cost-effective tool for evaluating the integrity and function of the central nervous system. Although imaging techniques, such as MRI, have recently become increasingly important in the diagnosis of neurological diseases, over the past 30 years, many neurologists have continued to employ EPs in specific clinical applications. This review presents an overview of the recent evolution of 'classical' clinical applications of EPs in terms of early diagnosis and disease monitoring and is an extension of a previous review published in this journal in 2005 by Walsh and collaborators. We also provide an update on emerging EPs based on gustatory, olfactory and pain stimulation that may be used as clinically relevant markers of neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and cortical or peripheral impaired pain perception. EPs based on multichannel electroencephalography recordings, known as high-density EPs, help to better differentiate between healthy subjects and patients and, moreover, they provide valuable spatial information regarding the site of the lesion. EPs are reliable disease-progression biomarkers of several neurological diseases, such as multiple sclerosis and other demyelinating disorders. Overall, EPs are excellent neurophysiological tools that will expand standard clinical practice in modern neurology.

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Section: Visual Evoked Potentialsmentioning

confidence: 93%

“…This method is more effective at detecting retrochiasmal and subclinical lesions, but the results are more difficult to analyse and interpret than standard VEPs 11. Both standard VEPs and mfVEPs complement OCT in examining the integrity of the prechiasmatic and retrochiasmatic segment of the optic nerve 12…”

Section: Visual Evoked Potentialsmentioning

confidence: 99%

Clinical evoked potentials in neurology: a review of techniques and indications

Lascano

Lalive

Hardmeier

et al. 2017

J Neurol Neurosurg Psychiatry

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“…Multifocal visual evoked potential (mfVEP) latency delays directly reflect demyelination, while decreased mfVEP amplitude reflects the following axonal loss or conduction block (Alshowaeir et al 2015). This makes the retina transparent for light moving towards the photoreceptors located in the outer retina.…”

Section: Introductionmentioning

confidence: 99%

Multifocal visual evoked potentials for quantifying optic nerve dysfunction in patients with optic disc drusen

Malmqvist

Santiago

Boquete

et al. 2017

Acta Ophthalmologica

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“…The method may be an objective electrophysiological tool for detection of visual field losses [2][3][4][5][6][7]. Recent studies have revealed the presence of topographical associations between losses in mfVEP and structural damages in patients with optic nerve disorders [4,8,9,10].…”

Section: Introductionmentioning

confidence: 99%

Steady-state multifocal visual evoked potential (ssmfVEP) using dartboard stimulation as a possible tool for objective visual field assessment

Horn

Selle

Hohberger

et al. 2015

Graefes Arch Clin Exp Ophthalmol

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Our results in normal subjects indicate that reliable mfVEP responses can be achieved by steady-state stimulation using a conventional dartboard stimulator and multi-channel electrode device. The ssmfVEP may be useful for objective visual field assessment as spectrum analysis can be used for automated evaluation of responses. The optimal reversal frequency is 8.6 Hz. Alpha waves have only a minor influence on the analysis. Future studies must include comparisons with conventional mfVEP and psychophysical visual field tests.

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Multifocal VEP assessment of optic neuritis evolution

Cited by 31 publications

References 25 publications

Clinical evoked potentials in neurology: a review of techniques and indications

Clinical evoked potentials in neurology: a review of techniques and indications

Multifocal visual evoked potentials for quantifying optic nerve dysfunction in patients with optic disc drusen

Steady-state multifocal visual evoked potential (ssmfVEP) using dartboard stimulation as a possible tool for objective visual field assessment

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