Multifocal ventricular tachycardia induced by etamon in a case of pheochromocytoma

Gould, Jarvis; Mundal, A.L.

doi:10.1016/0002-8703(51)90142-1

Cited by 12 publications

(1 citation statement)

References 11 publications

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“…This may be attributed to sinus tachycardia or any other arrhythmia as supraventricular or ventricular arrhythmias. Multi-focal ventricular tachycardia has been reported [40]. Zelinka et al reported arrhythmias in 15 (10.3%) out of 145 patients with pheochromocytoma [15].…”

Section: Ppgls and Arrhythmiasmentioning

confidence: 99%

Cardiovascular Manifestations and Complications of Pheochromocytomas and Paragangliomas

Y‐Hassan

Falhammar

2020

JCM

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Pheochromocytomas and paragangliomas (PPGLs) are rare neuro-endocrine tumors. The catecholamine surge causes paroxysmal or chronic secondary hypertension. PPGLs may present as hypertensive- or PPGL-crisis with severe life-threatening cardiac and cerebrovascular complications. PPGLs-induced cardiac manifestations have been reported with diagnoses as PPGLs-induced electrocardiogram (ECG) changes “mimicking acute myocardial infarction”, arrhythmias, myocarditis, acute coronary syndrome, dilated cardiomyopathy, and lately as takotsubo syndrome. Critical analysis of these reports reveals that most of these cardiac manifestations have certain features in common. They have a dramatic clinical presentation and are reversible if the disease is treated with appropriate medical therapy and surgical resection of the PPGL tumor. They may have the same repolarization ECG changes irrespective of the clinical cardiac diagnosis, usually associated with mild to moderate elevations of myocardial biomarkers as troponins and normal coronary arteries. The histopathological findings are usually focal or multifocal in the form hypercontracted sarcomeres and contraction band necrosis (myofibrillar degeneration) with subsequent secondary mononuclear cell infiltration. Evidences argue the PPGL caused surge of catecholamines triggers hyperactivation of the sympathetic nervous system with cardiac sympathetic nerve terminal disruption with norepinephrine spillover causing the cardiac complications. A comprehensive review of various reported cardiovascular manifestations and complications of PPGLs are presented.

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Section: Ppgls and Arrhythmiasmentioning

confidence: 99%

Cardiovascular Manifestations and Complications of Pheochromocytomas and Paragangliomas

Y‐Hassan

Falhammar

2020

JCM

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Pheochromocytoma Before and After Surgery

Levin¹

1953

AMA Arch Intern Med

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ALTHOUGH many excellent articles ' continue to review the literature of cases of paroxysmal hypertension produced by adrenal medulla tumors, little has been mentioned about the various endocrine manifestations of this condition. This paper, in addition to discussing the pharmacologic and roentgenographic means of diagnosis, will specifically emphasize the various endocrine findings and their significance.Selye 2 first called attention to the effects of stress on the adrenal-pituitary axis. Further work pointed to a specific relationship between epinephrine and this axis. Experimentation with epinephrine administration in animals and later in man resulted in a decrease in the circulating eosinophiles, decrease in adrenal ascorbic acid and cholesterol levels, and an increase in 17-ketosteroid excretion in the urine.3From these findings a test has been devised using subcutaneous injection of epinephrine to ascertain the integrity of this system.3a In cases of pheochromocytoma, in which epinephrine and arterenol (norepinephrine) have been found intermittently or constantly elevated in the blood stream, one is interested in the effects of these agents on the adrenal pituitary axis.

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Die Keimdrüsen und ihre Krankheiten

Jores¹

1955

Innersekretorische Und Stoffwechsel-Krankheiten

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Multifocal ventricular tachycardia induced by etamon in a case of pheochromocytoma

Cited by 12 publications

References 11 publications

Cardiovascular Manifestations and Complications of Pheochromocytomas and Paragangliomas

Cardiovascular Manifestations and Complications of Pheochromocytomas and Paragangliomas

Pheochromocytoma Before and After Surgery

Die Keimdrüsen und ihre Krankheiten

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