Multifocal splenic lesions in primary AL amyloidosis secondary to amyloidosis with giant cell granulomatous reaction

Abstract

A 63-year-old female with a remote history of clinically inactive lupus was evaluated for monoclonal gammopathy with nephrotic range proteinuria. Bone marrow exam showed 15% lambda restricted plasma cells with normal karyotype and monosomy 13 on fluorescent in-situ hybiridization analysis. Renal biopsy showed glomeruli with segmental mesangial expansion by amorphous, acellular, and eosinophilic material, which was Congo red positive, without crescents, tubular atro-F I G U R E 1 MRI of the abdomen T2 images showed splenic lesions as subtle hypo-intensity (A). Focal splenic lesions became conspicuous on delayed post-contrast images with enhancement (B) compared to the background parenchyma This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.