Multifocal skeletal tuberculosis: Experience in diagnosis and treatment

Liang, Hong; Wu, Jing; Ding, Jiao; Wang, Xiaoyang; Zheng, Ming‐Hua; Fu, Rong-Quan; Li, Wenbing; Peng, Wenxian; He, Wenfang; Sun, Qingfeng

doi:10.1016/j.medmal.2009.03.004

Cited by 34 publications

(33 citation statements)

References 19 publications

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“…Four to 6 bones or joints are usually affected, but as many as 19 different locations were described in a recent case report [30]. In children, the flat bones of the hand and foot are most commonly affected [17], but spinal involvement has also been reported [45].…”

Section: Multifocal Osteoarticular Tuberculosismentioning

confidence: 99%

Bone and joint tuberculosis

2012

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Section: Multifocal Osteoarticular Tuberculosismentioning

confidence: 99%

Bone and joint tuberculosis

2012

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“…Bone tissue can be obtained by computed tomography guided fine needle aspiration or surgical biopsy [12]. Histologic finding shows caseation necrosis surrounded by chronic inflammatory cells including epithelioid histiocytes and giant cells [13].…”

Section: Discussionmentioning

confidence: 99%

Tuberculous Osteomyelitis of the First Metatarsophalangeal Joint Misdiagnosed as Gouty Arthritis

et al. 2016

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A-43-year-old man visited our clinic due to pain and swelling of his left first metatarsophalangeal (MTP) joint since 6-months ago. He was diagnosed as gouty arthritis at private clinic and took hypouricemic agent, but he had progressive pain and swelling. There was swelling, erythema and tenderness and ulceration at base of the left first MTP joint. His laboratory results showed elevated C-reactive protein and normal serum uric acid level. The plain radiograph of foot showed bone destruction of left first MTP joint. MRI revealed joint space narrowing, soft tissue swelling and subchondral cyst. He underwent excisional biopsy and histology demonstrated chronic granulomatous inflammation with caseation necrosis. Tissue polymerase chain reaction for mycobacterium tuberculosis was positive. He was diagnosed as tuberculous osteomyelitis. He started on quadruple anti-tuberculous therapy and his symptom was improved. Early diagnosis and anti-tuberculosis therapy could lead to improve outcomes. (J Rheum Dis 2016;23:311-315)

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“…Multifocal skeletal forms are exceptional even in endemic countries and affect mainly immunocompromised patients. It is usually associated with a primary pulmonary tuberculosis 1,2 . Clinical presentation is often misleading and contributes to a delay in diagnosis.…”

Section: To the Editormentioning

confidence: 99%