Multifocal sclerosing angiomatoid nodular transformation of the spleen: a case report and review of literature

Cao, Zhixin; Wang, Qiangxiu; Li, Jiamei; Xu, Jiawen; Li, Jianfeng

doi:10.1186/s13000-015-0312-2

Cited by 28 publications

(38 citation statements)

References 16 publications

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“…Zhixin et al reviewed 127 patients with SANT. In this report, a slight female preponderance is evident, and predominantly affects middle-aged adults according to a review [7]. Although the exact nature of this disease remains unclear, SANT is considered benign and does not present with recurrence or malignant behavior [8].…”

Section: Discussionmentioning

confidence: 73%

Sclerosing angiomatoid nodular transformation of the spleen presenting rapid growth after adrenalectomy: Report of a case

Nagai

Satoh

Matsukawa

et al. 2017

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 73%

Sclerosing angiomatoid nodular transformation of the spleen presenting rapid growth after adrenalectomy: Report of a case

Nagai

Satoh

Matsukawa

et al. 2017

International Journal of Surgery Case Reports

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“…In 95% of cases, SANT manifests itself as a solitary splenic lesion. Only five cases of multifocal SANT have been reported to date [5]. In one case report, only the accessory spleen was primarily affected [6].…”

Section: Discussionmentioning

confidence: 99%

Sclerosing angiomatoid nodular transformation of the spleen - An uncommon splenic pseudotumorus variant

Grubor¹,

Tadić²,

Micev

et al. 2019

Srp Arh Celok Lek

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Introduction Sclerosing angiomatoid nodular transformation is a benign splenic pseudotumorous multinodular vascular proliferation. In the past, it was usually reported as splenic hamartoma, multinodular hemangioma or splenic hemangioendothelioma. Since it was defined in 2004, a total of 150 cases have been reported. We will present our experience with a 58-year-old female patient who underwent splenectomy due to the tumorous change in the upper pole of the spleen, histopathologically characterized as sclerosing angiomatoid nodular transformation of the spleen. Case outline A 58-year-old women presented with abdominal pain, anemia, elevated C-reactive protein and fibrinogen level. Abdominal ultrasound and MDCT scan found a well-circumscribed, homogeneous, low-density tumor in the upper pole of the spleen. As the nature of the tumorous change could not be accurately determined and malignancy could not be excluded, splenectomy was performed. Histological findings showed multiple similar nodular foci, hardly discernible from splenic parenchyma, angiomatoid nodules surrounded and separated by partly collagenized fibroblastic areas admixed with mononuclear inflammatory infiltrate in various proportions. All findings were characterized as the coexistence of sclerosing angiomatoid nodular transformation of the spleen and splenic inflammatory pseudotumor. Conclusion Splenectomy, laparoscopic or open, is an acceptable therapeutic and at the same time diagnostic method. Considering the important role of the spleen in the immune system, partial splenectomy is also an option, especially in children. However, the coexistence of sclerosing angiomatoid nodular transformation of the spleen and inflammatory pseudotumor indicates a careful treatment decision, given the tendency of inflammatory pseudotumor to relapse, and, rarely, the possibility of malignant transformation.

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“…Spleen biopsy can be performed and makes the diagnosis. [2] Ultrasound guided percutaneous splenic biopsy is an accurate and relatively safe procedure. Major complication risk (1.3%) does not exceed other solid abdominal organ biopsies , and has less mortality and morbidity than splenectomy.…”

Section: Discussionmentioning

confidence: 99%

“…First described [1] as a solitary angioma-like disease of the spleen in 2004, there are now 129 cases reported in the literature. [2] The majority of the cases described are solitary nodules. However, there are 6 case reports of multiple SANT of the spleen.…”

Section: Introductionmentioning

confidence: 99%

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Rare tumor of the spleen - case report

Meireles

Cunha

Iglesias

et al. 2016

CRIM

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Sclerosing angiomatoid nodular transformation was first described as a solitary angioma-like disease of the spleen by Martel et al. in 2004. It is a relatively new rare benign lesion. The authors present a clinical case of an asymptomatic, 48-year-old female. SANT has been an incidental finding in an abdominal ultrasound. Histological appearance and the immunohistochemical staining after spleen biopsy confirmed the diagnosis. As suggested in previously published articles, a splenectomy was performed for definitive treatment. This case contributes to the differential diagnosis of splenic tumors, its treatment and clinical impact.

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Multifocal sclerosing angiomatoid nodular transformation of the spleen: a case report and review of literature

Cited by 28 publications

References 16 publications

Sclerosing angiomatoid nodular transformation of the spleen presenting rapid growth after adrenalectomy: Report of a case

Sclerosing angiomatoid nodular transformation of the spleen presenting rapid growth after adrenalectomy: Report of a case

Sclerosing angiomatoid nodular transformation of the spleen - An uncommon splenic pseudotumorus variant

Rare tumor of the spleen - case report

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