Multifocal, Persistent Cardiac Uptake of [18-F]-Fluoro-Deoxy-Glucose Detected by Positron Emission Tomography in Patients With Acute Myocardial Infarction

Godino, Cosmo; Messa, Cristina; Landoni, Claudio; Margonato, Alberto; Cera, Michela; Coli, Stefano; Cianflone, Domenico; Fazio, Ferruccio; Maseri, Attilio

doi:10.1253/circj.cj-08-0046

Cited by 7 publications

(7 citation statements)

References 28 publications

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“…14 MicroPET has been used for monitoring metabolic events in the myocardium of small animals in stem cell transplantation after myocardial infarction, 41,42 progressive hypertrophy, 43 and left ventricular dilation. 44 Increased FDG uptake has been shown in vitro in leukocytes, 45 lymphocytes, and macrophages 46,47 and in vivo in acute myocardial infarction, 48 abdominal aortic aneurism, 49 and atherosclerosis. 50 The increased uptake of FDG in T. cruzi -infected mice correlates with the intense and diffuse myocarditis observed during the acute phase and chronic inflammation and myocardium reparative fibrosis that occurs during the chronic phase.…”

Section: Discussionmentioning

confidence: 99%

Micro-Positron Emission Tomography in the Evaluation of Trypanosoma cruzi-Induced Heart Disease: Comparison with Other Modalities

Prado¹,

Fine²,

Koba³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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Abstract. Noninvasive assessment of cardiac structure and function is essential to understand the natural course of murine infection with Trypanosoma cruzi . Magnetic resonance imaging (MRI) and echocardiography have been used to monitor anatomy and function; positron emission tomography (PET) is ideal for monitoring metabolic events in the myocardium. Mice infected with T. cruzi (Brazil strain) were imaged 15-100 days post infection (dpi). Quantitative 18 F-FDG microPET imaging, MRI and echocardiography were performed and compared. Tracer ( 18 F-FDG) uptake was significantly higher in infected mice at all days of infection, from 15 to 100 dpi. Dilatation of the right ventricular chamber was observed by MRI from 30 to 100 dpi in infected mice. Echocardiography revealed significantly reduced ejection fraction by 60 dpi. Combination of these three complementary imaging modalities makes it possible to noninvasively quantify cardiovascular function, morphology, and metabolism from the earliest days of infection through the chronic phase.

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Section: Discussionmentioning

confidence: 99%

Micro-Positron Emission Tomography in the Evaluation of Trypanosoma cruzi-Induced Heart Disease: Comparison with Other Modalities

Prado¹,

Fine²,

Koba³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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“…This widespread inflammation is in agreement with post-mortem observations [31,36]. (Modified from Godino et al [27], with permission) severity or plaque morphology does not allow to efficiently predict ACS [35,36]. Indeed, on the one hand, plaque fissure can be an asymptomatic event [37] and is frequently observed in stable CAD [38].…”

Section: Assessment Of Inflammatory Cell Activation In Atherosclerotimentioning

confidence: 55%

“…3). A possible explanation might reside into the hypothesis that inflammatory cells could be responsible for this 18 FDG enhancement not only in infarcted but also in remote myocardial regions [27]. In fact, in the acute phase of STEMI, several cytokines, released in infarcted regions and involved in migration of leucocytes, could increase glucose uptake in inflammatory [28] and endothelial cells, by translocation of the glucose transporter from the cytoplasm to the plasma membrane [29,30]; thus, uptake of 18 FDG at follow-up could be related to widespread coronary microvascular and myocardial inflammation [31,32].…”

Section: Assessment Of Myocardial Perfusion and Metabolismmentioning

confidence: 99%

Positron Emission Tomography in Acute Coronary Syndromes

Galiuto

Paraggio

Caterina

et al. 2011

J. of Cardiovasc. Trans. Res.

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Several imaging techniques have been used to assess cardiac structure and function, to understand pathophysiology, and to guide clinical decision making in the setting of acute coronary syndromes (ACS). Over the last years, cardiac positron emission tomography (PET) has affirmed its role in this setting. Indeed, the combined quantitative assessment of myocardial metabolism and perfusion has allowed to better understand the functional status of infarcted and non-infarcted myocardium, thus improving our knowledge of myocardial response to necrosis. More recently, several studies, taking advantage of previous observations in patients with cancer, have shown that PET could also provide important information on the mechanisms of vascular instability through the early identification of activated inflammatory cells in the atherosclerotic plaque. These findings are opening the way to more effective forms of prevention of acute vascular syndromes in high-risk patients; furthermore, new more sensitive and specific tracers for the identification of vascular inflammation are under development. In this review, we describe the potential and limitations of PET in the assessment of ACS.

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“…31 Beyersdolf et al reported in an animal study that in cases of single-vessel disease, increased glucose metabolism associated with increases in blood flow and endogenous adenosine in normal areas adjacent to the infarct region causes mild increases in 18 F-FDG uptake and excessive contraction of the myocardium in areas not affected by culprit lesions because of abnormalities in vasodilators after MI. 32 Godino et al 33 reported that in the first AMI of single-vessel disease, abnormal accumulation of 18 F-FDG outside of isch- emic areas was observed, which was caused by the stimulation of GLUT-1 because of the inflammation associated with the MI. They also observed abnormal accumulation of 18 F-FDG at 1 year after the AMI.…”

Section: Serial Changes Inmentioning

confidence: 99%

Serial Changes in Glucose-Loaded 18F-Fluoro-2-Deoxyglucose Positron Emission Tomography, 99mTc-Tetrofosmin and 123I-Beta-Methyl-p-Iodophenyl-Penta-Decanoic Acid Myocardial Single-Photon Emission Computed Tomography Images in Patients With Anterior Acute Myocardial Infarction

Fukuoka

Horita

Namura

et al. 2013

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp he energy metabolism of the heart and the utilization of substrates including glucose, fatty acids, amino acids, lactic acid and ketone bodies depend on circumstances, 1 and are primarily based on fatty acid metabolism and glucose metabolism in a competitive manner. 2 However, a shift to anaerobic metabolism because of low oxygen supplies causes ischemic myocardium to primarily utilize glucose. 3,4 Many reports have discussed whether maintaining glucose metabolism is important in estimating the viability of ischemic myocardium, and some reports indicate that improvements in left ventricular function and the prevention of cardiac events are achieved with the use of aggressive revascularization procedures. 5-9 The use of glucose-loaded 18 F-fluoro-2-deoxyglucose ( 18 F-FDG) PET has played a central role in helping cardiovascular interventionalists decide whether revascularization procedures are indicated in patients with old myocardial infarction (MI) with residual stenosis and angina pectoris. 10-13 18 F-FDG-PET has been also utilized to evaluate systemic inflammatory diseases, including malignancies, because 18 F-FDG accumulates in sites of inflammation. 14,15 Therefore, appropriate timing for the evaluation of glucose-loaded 18 F-FDG-PET images of acute MI (AMI) has been conventionally considered T

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Multifocal, Persistent Cardiac Uptake of [18-F]-Fluoro-Deoxy-Glucose Detected by Positron Emission Tomography in Patients With Acute Myocardial Infarction

Cited by 7 publications

References 28 publications

Micro-Positron Emission Tomography in the Evaluation of Trypanosoma cruzi-Induced Heart Disease: Comparison with Other Modalities

Micro-Positron Emission Tomography in the Evaluation of Trypanosoma cruzi-Induced Heart Disease: Comparison with Other Modalities

Positron Emission Tomography in Acute Coronary Syndromes

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