Multifocal objective perimetry compared with Humphrey full‐threshold perimetry in patients with optic neuritis

Pakrou, Nima; Casson, Robert J.; Kaines, Andrew; Selva, Dinesh

doi:10.1111/j.1442-9071.2006.01277.x

Cited by 12 publications

(15 citation statements)

References 19 publications

(33 reference statements)

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“…This substantially reduces intersubject variability and allows more reliable comparison with a normal database for applying mfVEP in the detection of visual field changes clinically. 12 A number of studies have shown that AccuMap mfVEP can provide a good measurement of visual field defects in glaucomatous optic neuropathy, 5,13-15 optic neuritis, 7,16 compressive optic neuropathy, 6 and other conditions. [17][18][19] Strong correlation has been observed between areas of visual field loss on Humphrey subjective perimetry and mfVEP amplitude.…”

Section: Discussionmentioning

confidence: 99%

“…An AccuMap Severity Index (ASI) score was also displayed based on the total number of abnormal zones, relative severity, and asymmetry. By comparing the results with a built-in normative database of 100 patients, the ASI was classified as normal (within 95% confidence interval (CI), ASI 0-11), borderline (95-99% CI, ASI [11][12][13][14][15][16][17][18][19], or outside normal limits (outside 99% CI, ASI419).…”

Section: Methodsmentioning

confidence: 99%

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Application of multifocal visual evoked potentials in the assessment of visual dysfunction in macular diseases

Jiang

Zhang

Xie

et al. 2011

Eye

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Application of multifocal visual evoked potentials in the assessment of visual dysfunction in macular diseases

Jiang

Zhang

Xie

et al. 2011

Eye

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“…They found a comparable amplitude loss of mfVEP response in region with bitemporal visual defect. Several studies in non-glaucomatous optic neuropathy [38][39][40] and in glaucomatous optic neuropathy [32,[41][42][43] have also shown that correspondence exists between visual field defect determined by perimetry and the reduction of mfVEP amplitude. Latencies were non-recordable (gray circles in column 5 and 6 in Fig.…”

Section: Discussionmentioning

confidence: 99%

Multifocal visual evoked potential recordings in compressive optic neuropathy secondary to pituitary adenoma

et al. 2010

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To investigate the effect of pituitary adenoma compressing the optic chiasm on multifocal visual evoked potential (mfVEP) responses and to compare these responses with visual field defects seen on static automated perimetry (SAP). Eight eyes of four subjects (median age, 41.50 years; interquartile range, 33-51 years) who were diagnosed with pituitary adenoma on magnetic resonance imaging (MRI) and seen to have a bitemporal visual field defect on standard automated perimetry (SAP), and twelve age-matched normal subjects (median age, 47.00 years; interquartile range, 34.75-51.75 years) were subjected to multifocal visual evoked potential (mfVEP) testing. The monocular latencies and monocular amplitudes of each sector of cases were compared with the responses of normative database. The topography of the mfVEP response was compared with corresponding field defect as seen in total deviation threshold on SAP to allow a comparison with conventional subjective perimetry. The mfVEP amplitudes were reduced in the areas with visual field defect on SAP. In 6 out of 8 eyes, locations with preserved amplitudes and no visual defects showed prolonged latency. A prolonged median latency of 9.17 ms (interquartile range, 3.44-17.69 ms) in cases was seen when compared to the median latency of 1.67 ms (interquartile range, 0.94-4.17 ms) in age-matched controls with P value of 0.054. Chiasmal compression due to pituitary adenoma causes the reduction of amplitudes and prolongation of latencies of the mfVEP response. The mfVEP can be used to assess objectively the topography of the visual field in compressive optic neuropathy secondary to pituitary adenomas. It can be used in assessing the subjects whose visual field report is unreliable and prolonged median latency can be an early sign of the disease.

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“…[343738394041] In this study, we have analyzed the size of the amplitude reduction and its pattern in mfVEP topographical amplitude deviation map among optic nerve disorders using the visual field profile classification of ONTT as shown in Fig. 1.…”

Section: Discussionmentioning

confidence: 99%

“…Pakrou et al .,[43] reported that only 8.3% of the 16 optic neuritis subjects showed a central or centrocecal mfVEP defect using cluster criteria. Laron et al .,[37] analyzed the mfVEP amplitude and latency abnormality using cluster criteria in MS-ON eyes. They reported that although abnormal sectors were diffusely distributed, the central 10° was more affected than periphery.…”

Section: Discussionmentioning

confidence: 99%

Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy

Jayaraman

Gandhi

Ravi

et al. 2014

Indian J Ophthalmol

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Purpose:To investigate the effect of optic neuritis (ON), ischemic optic neuropathy (ION) and compressive optic neuropathy (CON) on multifocal visual evoked potential (mfVEP) amplitudes and latencies, and to compare the parameters among three optic nerve disorders.Materials and Methods:mfVEP was recorded for 71 eyes of controls and 48 eyes of optic nerve disorders with subgroups of optic neuritis (ON, n = 21 eyes), ischemic optic neuropathy (ION, n = 14 eyes), and compressive optic neuropathy (CON, n = 13 eyes). The size of defect in mfVEP amplitude probability plots and relative latency plots were analyzed. The pattern of the defect in amplitude probability plot was classified according to the visual field profile of optic neuritis treatment trail (ONTT).Results:Median of mfVEP amplitude (log SNR) averaged across 60 sectors were reduced in ON (0.17 (0.13-0.33)), ION (0.14 (0.12-0.21)) and CON (0.21 (0.14-0.30)) when compared to controls. The median mfVEP relative latencies compared to controls were significantly prolonged in ON and CON group of 10.53 (2.62-15.50) ms and 5.73 (2.67-14.14) ms respectively compared to ION group (2.06 (-4.09-13.02)). The common mfVEP amplitude defects observed in probability plots were diffuse pattern in ON, inferior altitudinal defect in ION and temporal hemianopia in CON eyes.Conclusions:Optic nerve disorders cause reduction in mfVEP amplitudes. The extent of delayed latency noted in ischemic optic neuropathy was significantly lesser compared to subjects with optic neuritis and compressive optic neuropathy. mfVEP amplitudes can be used to objectively assess the topography of the visual field defect.

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Multifocal objective perimetry compared with Humphrey full‐threshold perimetry in patients with optic neuritis

Abstract: The mfVEP detected more abnormalities in patients with ON than HVF perimetry. The use of latency recordings as well as combined amplitude and asymmetry plots is advantageous and has the potential to detect abnormalities not otherwise detected on HVF perimetry.

Cited by 12 publications

References 19 publications

Application of multifocal visual evoked potentials in the assessment of visual dysfunction in macular diseases

Application of multifocal visual evoked potentials in the assessment of visual dysfunction in macular diseases

Multifocal visual evoked potential recordings in compressive optic neuropathy secondary to pituitary adenoma

Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy

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