Multifocal Necrotizing Leukoencephalopathy Mimicking Sporadic Creutzfeldt-Jakob Disease

Imperiale, Daniele; Taraglio, Stefano; Atzori, Cristiana; Testi, Roberto; Buffa, Carlo; Migheli, Antonio

doi:10.1159/000121425

Search citation statements

Order By: Relevance

Paper Sections

Select...

Case History1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2017

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is also one patient described with septic shock,2 which may in itself have an immunosuppressant effect 3. There is one case report of a non-immunosuppressed patient with hyponatraemia whose MR scan of brain, electroencephalogram and CSF analysis mimicked sporadic Creutzfeldt-Jakob disease 4. This patient had mildly high signal on MR diffusion-weighted imaging in the parietal cortex, periodic spike–wave complexes on electroencephalogram and a positive CSF protein 14-3-3.…”

Section: Case Historymentioning

confidence: 99%

Multifocal necrotising leucoencephalopathy following Salmonella infection in an immunocompetent patient

et al. 2017

View full text Add to dashboard Cite

Multifocal necrotising leucoencephalopathy is a rare disorder affecting the central nervous system. It is characterised pathologically by microscopic areas of necrosis with pontine predilection but also involvement of extrapontine regions, including the cerebellum, medulla and cerebral hemispheres. It usually occurs on the background of immunosuppression. Here we describe an immunocompetent patient with a recent history of Salmonella infection who presented with subacute neurological deterioration. At postmortem, she had evidence of multifocal necrotising leucoencephalopathy.

show abstract

Section: Case Historymentioning

confidence: 99%