Multifocal necrotising steatites associated with pancreatic carcinoma in three dogs

Brown, Peter; Mason, Kenneth; Merrett, Darren; Mirchandani, Sunil; Miller, Rafael

doi:10.1111/j.1748-5827.1994.tb03913.x

Cited by 25 publications

(21 citation statements)

References 8 publications

(2 reference statements)

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“…Cytology of impression smears or fine needle aspirates of the skin lesions indicated the presence of suppurative, pyogranulomatous, or granulomatous inflammation with variable necrosis as has been reported by others 2,7,8,14 . However, these findings are not specific for SNP, and 2 cases in the present report were interpreted as possibly neoplastic, indicating that cytology alone is inadequate for diagnosis and can be misleading.…”

Section: Discussionsupporting

confidence: 74%

“…SNP is an idiopathic disorder 1,3–5 that is either primary in origin or associated with a variety of other illnesses, including pancreatic nodular hyperplasia, 6 pancreatic neoplasia, 7–9 pancreatitis, 10 and immunologic diseases such as rheumatoid arthritis 11 and systemic lupus erythematosus (SLE) 3 . Concurrent inflammation of fat in the abdomen, 12 epidural space, 13 and bone 7 can occur in dogs with SNP, as can other inflammatory conditions such as polyarthritis 7 .…”

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confidence: 99%

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Canine Sterile Nodular Panniculitis: A Retrospective Study of 14 Cases

O'Kell¹,

Inteeworn²,

Diaz³

et al. 2010

Journal of Veterinary Internal Medicine

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Background: Sterile nodular panniculitis (SNP) is an uncommon inflammatory condition of subcutaneous fat that can be idiopathic, but has also been associated with underlying conditions such as pancreatic disease or systemic lupus erythematosus (SLE). The pathogenesis and clinical course of the condition are not well understood.Objectives: To retrospectively review cases of SNP associated with systemic signs, concurrent disease, or both and characterize the clinical, laboratory, imaging, and histopathologic findings, treatment, and response to treatment.Animals: Fourteen dogs with histologically confirmed SNP diagnosed between 1996 and 2008. Methods: Retrospective study.Results: Skin lesions were ulcerated or draining nodules in 9 dogs and nonulcerative subcutaneous nodules in 5. Most dogs had systemic signs, such as fever, inappetence, lethargy, and multiple lesions. Common clinicopathologic findings included neutrophilia with or without left shift, increased alkaline phosphatase activity, mild hypoglycemia, hypoalbuminemia, and proteinuria. Concurrent diseases included pancreatic disease, SLE, rheumatoid arthritis, polyarthritis, lymphoplasmacytic colitis, and hepatic disease. Dogs responded to immunosuppressive doses of corticosteroids when administered. Prognosis for recovery was related to the underlying disease process.Conclusions and Clinical Importance: SNP is not a single disease. Rather, it is a cutaneous marker of systemic disease in many cases. After thorough evaluation for concurrent disease and infectious causes, immunosuppressive treatment is often effective.

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Section: Discussionsupporting

confidence: 74%

mentioning

confidence: 99%

Canine Sterile Nodular Panniculitis: A Retrospective Study of 14 Cases

O'Kell¹,

Inteeworn²,

Diaz³

et al. 2010

Journal of Veterinary Internal Medicine

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“…5 and 6) of the study population were diagnosed with panniculitis. Panniculitis associated with pancreatic neoplasia has been reported in humans, 5 dogs, 4 and cats. 8 The pathogenesis of ''pancreatic panniculitis'' is unknown; however, it has been speculated that it may be the result of lipolytic pancreatic enzymes reaching systemic circulation 18 or the result of a deficiency in serum enzyme inhibitors, including a 1 -antitrypsin or a 2 -macroglobulin.…”

Section: Discussionmentioning

confidence: 99%

“…12,23 In all species, ''pancreatic panniculitis'' is an uncommon sequel to pancreatic disease with a poor prognosis. 4,5,8 Therefore, it is surprising that 2 of 6 dogs (33%) of the study population had panniculitis. It is possible that in one or both of these dogs, panniculitis was an incidental condition unrelated to pancreatic disease.…”

Section: Discussionmentioning

confidence: 99%

Hyalinizing Pancreatic Adenocarcinoma in Six Dogs

Dennis

O’Brien²,

Tsang

et al. 2008

Vet Pathol

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Abstract. Exocrine pancreatic carcinoma is a particularly malignant neoplasm of the dog. Clinical and pathologic findings of an unusual variant of exocrine pancreatic neoplasia termed hyalinizing pancreatic adenocarcinoma were evaluated in 6 dogs. On microscopic examination, neoplasms were composed of tubules and acini of epithelial cells, with bright eosinophilic granular apical cytoplasm. Tubular lumina and tumor stroma contained abundant hyaline material that resembled amyloid. The hyaline material was not congophilic, and tumor cells and hyaline material were immunohistochemically negative for amyloid A, immunoglobulin light chains (k and l), amylin (islet amyloid polypeptide), laminin, and a 1 -antitrypsin. Two patients survived longer than 15 months after diagnosis; one of these dogs was untreated and had grossly evident metastasis at the time of diagnosis. The deaths of the other 4 dogs occurred as a result of poor recovery after partial pancreatectomy or in association with other concurrent life-threatening conditions. Two dogs were diagnosed with panniculitis, a condition rarely associated with pancreatic disease. Further evaluation is needed to determine the composition and biologic significance of intratumor hyaline material. Studies that associate exocrine pancreatic carcinoma grade and histologic subtype with prognostic outcomes in the dog are warranted such that appropriate therapy can be elected.

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“…61 Some dogs with pancreatic neoplasia have been reported with multifocal steatitis. 62 Typical clinicopathologic findings reflect the accompanying pancreatic inflammation or necrosis as well as involvement with other abdominal organs.…”

Section: Pancreatic Neoplasiamentioning

confidence: 99%

Practical Interpretation and Application of Exocrine Pancreatic Testing in Small Animals

Mansfield

2015

Clinics in Laboratory Medicine

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Multifocal necrotising steatites associated with pancreatic carcinoma in three dogs

Cited by 25 publications

References 8 publications

Canine Sterile Nodular Panniculitis: A Retrospective Study of 14 Cases

Canine Sterile Nodular Panniculitis: A Retrospective Study of 14 Cases

Hyalinizing Pancreatic Adenocarcinoma in Six Dogs

Practical Interpretation and Application of Exocrine Pancreatic Testing in Small Animals

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