Multifocal lateral and fourth ventricular B-cell primary CNS lymphoma

Brar, Rahat; Prasad, Abhishek; Sharma, Tarun; Vermani, Nittin

doi:10.1016/j.clineuro.2011.10.020

Cited by 17 publications

(18 citation statements)

References 6 publications

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“…Our case is unusual in that the lesion is isolated to the fourth ventricle, an extremely rare location that has only been documented in three other cases in literature [3–5] with an additional case having an associated lateral ventricle focus [10]. A solitary enhancing mass in an immunocompetent patient that forms a cast of the fourth ventricle should raise the suspicion of an ependymoma or, less likely, a subependymoma or medulloblastoma.…”

Section: Discussionmentioning

confidence: 79%

Primary Isolated Lymphoma of the Fourth Ventricle in an Immunocompetent Patient

Bokhari

Ghanem²,

Al-Ahwal³

et al. 2013

Case Reports in Oncological Medicine

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Primary central nervous lymphoma (PCNSL) is a rare variant of extranodal non-Hodgkin's lymphoma with a especially poor prognosis. The diagnosis is usually encountered in immunodeficient patients but is also encountered, albeit uncommonly, in the immunocompetent. We present a 50-year-old male who developed signs and symptoms of increased intracranial pressure. Imaging revealed the presence of a fourth ventricle mass with obstructive hydrocephalus. First, the patient underwent emergency endoscopic third ventriculostomy followed, few days later, by complete tumor resection via a posterior fossa craniotomy. Postoperative histopathology revealed the lesion to be a PCNSL. He received adjuvant chemotherapy and radiation and remained with no recurrence on regular imaging studies for 18-month followup. We report herein the fourth case of isolated PCNSL lesion to the fourth ventricle in the literature and provide the rationale for our belief that craniotomy and tumor resection, if feasible, should be the initial line of management in similar cases to relieve hydrocephalus and achieve the diagnosis.

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Section: Discussionmentioning

confidence: 79%

Primary Isolated Lymphoma of the Fourth Ventricle in an Immunocompetent Patient

Bokhari

Ghanem²,

Al-Ahwal³

et al. 2013

Case Reports in Oncological Medicine

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“…PCNSLs represent 0.7-1.7% of all malignant brain tumors, occurring in more than 50% of cases in supra-tentorial areas. 4,5 They are characterized by high aggressiveness and rapid growth. Symptoms appear in 3-6months and can be aspecific, including headache, cognitive deficits, and psychomotor slowing.…”

Section: Discussionmentioning

confidence: 99%

Critical revision of the role of surgery for treatment of primary brain b cell lymphoma in an immunocompetent patient: a case report and literature review

Rizzi¹

2018

JNSK

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Primary Central Nervous System Lymphoma (PCNSL) are malignant tumors extremely rare in immunocompetent patients. They represent 2-3% of all cerebral tumors.They are frequently located in the supra-tentorial space and in 60-70% of cases they consist in single lesions. The most common presenting symptoms are hemi paresis, ache, epileptic crises and ataxia. In this article we present the case of a 76 year-old woman admitted for seizures attack and progressive coma state. A preoperative CT scan with contrast enhancement showed a left frontal nodular lesion of 29x16mm, with irregulars enhancement and surrounded by peripheral edema. No alteration of haematological exams was noticed. The patient underwent surgery for with total excision of the lesion. Histological examination was suggestive of non-Hodgkin B cells lymphoma (CD20+, CD 30-). Patient improved after surgery and she was discharged ten days after surgery, with the indication to perform hematologic consult. No recurrences were noticed at 20months follow-up. Although surgery is not routinely recommended for the treatment of PCNSL, we report a case of B-cells lymphoma in which surgical resection, followed by chemotherapy and radiation therapy, resulted in a successful treatment. A critical review of the role of the surgery in consideration of technical advances in neurosurgery was done.

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“…Les LCP impliquant les ventricules sont généralement développés dans la zone périventriculaire et font saillie dans les cavités ventriculaires. La localisation pure et isolée du quatrième ventricule (V4) est exceptionnelle, sept cas ayant été rapportés à ce jour dans la littérature [4][5][6][7][8][9][10]. Ces cas sont résumés dans le tableau 1.…”

Section: Discussionunclassified

“…À l'instar des autres auteurs, malgré l'aspect de la lésion à l'IRM, qui et a posteriori était compatible avec un lymphome, celui-ci n'avait pas été évoqué parmi les hypothèses diagnostiques du fait de la rareté de cette localisation. Certains proposent d'inclure le lymphome primitif dans la liste des diagnostiques différen-tiels des lésions du quatrième ventricule, bien limitées et se rehaussant de façon intense et homogène après gadolinium [5][6][7][8]10].…”

Section: Discussionunclassified

Lymphome primitif à grandes cellules B du quatrième ventricule : cas clinique et revue de la littérature

et al. 2015

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Nous rapportons le cas d'un lymphome B diffus primitif isolé du quatrième ventricule. Il s'agissait d'une femme de 70 ans adressée pour céphalées, vertiges et une démarche instable évoluant depuis trois semaines. L'imagerie cérébrale par résonance magnétique objectivait une lésion du quatrième ventricule bien limitée, se rehaussant de façon intense et homogène après gadolinium faisant évoquer un gliome ou une métastase. Elle a été opérée après qu'un bilan systémique n'a pas retrouvé d'autres localisations (imagerie, biologie sanguine…). L'exérèse complète était réalisée. L'histopathologie a conclu à un lymphome B diffus à grandes cellules avec un phénotype de cellules B activées. La recherche d'autres localisations était négative. Une polychimiothérapie à base de Méthotrexate a été administrée. L'évolution était favorable avec un recul de 10 mois sans récidive. A la lumière de ce cas rare de localisation cérébel-leuse lymphomateuse du 4ème ventricule, une revue exhaustive de la littérature est proposée. Mots clés Lymphome B · Quatrième ventricule · ChimiothérapieAbstract We herein present the case of a 70 year-old woman admitted with a 3 weeks history of headaches, vertigo and gait instability. Brain imaging revealed an isolated wellcircumscribed and enhancing lesion of the fourth ventricle suggesting either a glioma or a metastasis. A systemic checkup including hole body CT-scan did not reveal any other lesion. Therefore a complete microsurgical removal of the tumor was performed with uneventful postoperative course. The pathological assessment confirmed the diagnosis of a diffuse B cell lymphoma with an activated B cells' phenotype. The patient underwent a successful polychemotherapy including Methotrexate. A 10 months follow-up is available with disease-free course. Emphasizing on this very rare case, we provide an exhaustive review of the literature.

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Multifocal lateral and fourth ventricular B-cell primary CNS lymphoma

Cited by 17 publications

References 6 publications

Primary Isolated Lymphoma of the Fourth Ventricle in an Immunocompetent Patient

Primary Isolated Lymphoma of the Fourth Ventricle in an Immunocompetent Patient

Critical revision of the role of surgery for treatment of primary brain b cell lymphoma in an immunocompetent patient: a case report and literature review

Lymphome primitif à grandes cellules B du quatrième ventricule : cas clinique et revue de la littérature

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