Multifocal intradiploic cavernous hemangioma of the skull associated with nasal osteoma

Kuzeylı, Kayhan; Usul, Haydar; Çakır, Ertuğrul; Çaylan, Refik; Rei, A. J. M. Del; Baykal, Süleyman; Peksoylu, Bekircan; Yazar, Uğur; Arslan, Ersin

doi:10.1007/s00701-003-0005-6

Cited by 16 publications

(10 citation statements)

References 12 publications

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“…Glia constitutively express receptors involved in cerebral innate immune responses and upon activation, may secrete pro-inflammatory mediators to recruit peripheral immune cells to the site of injury [10]; however, the functional significance and cellular mediators of cerebral innate immune activation remains unresolved. Cellular necrosis correlates with the development of peri-contusional brain edema after TBI and surgical excision of necrotic tissue reduces ICP, decreases patient mortality, and improves neurological outcomes in neurotrauma patients [11], [12], [13]. Thus, necrotic cell death may initiate post-traumatic immune responses.…”

Section: Introductionmentioning

confidence: 99%

Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice

et al. 2012

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Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Cerebral edema, the abnormal accumulation of fluid within the brain parenchyma, contributes to elevated intracranial pressure (ICP) and is a common life-threatening neurological complication following TBI. Unfortunately, neurosurgical approaches to alleviate increased ICP remain controversial and medical therapies are lacking due in part to the absence of viable drug targets. In the present study, genetic inhibition (P2X7−/− mice) of the purinergic P2x7 receptor attenuated the expression of the pro-inflammatory cytokine, interleukin-1β (IL-1β) and reduced cerebral edema following controlled cortical impact, as compared to wild-type mice. Similarly, brilliant blue G (BBG), a clinically non-toxic P2X7 inhibitor, inhibited IL-1β expression, limited edemic development, and improved neurobehavioral outcomes after TBI. The beneficial effects of BBG followed either prophylactic administration via the drinking water for one week prior to injury or via an intravenous bolus administration up to four hours after TBI, suggesting a clinically-implementable therapeutic window. Notably, P2X7 localized within astrocytic end feet and administration of BBG decreased the expression of glial fibrillary acidic protein (GFAP), a reactive astrocyte marker, and attenuated the expression of aquaporin-4 (AQP4), an astrocytic water channel that promotes cellular edema. Together, these data implicate P2X7 as a novel therapeutic target to prevent secondary neurological injury after TBI, a finding that warrants further investigation.

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Section: Introductionmentioning

confidence: 99%

Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice

et al. 2012

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“…24) Only 9 cases (including the present case) with histologically proven multiple hemangiomas of the skull have been reported (Table 1). 2,5,[13][14][15][16]19,23) Most patients complained of pain or swelling, and the histological diagnosis was cavernous hemangioma. These findings are compatible with unifocal cases.…”

Section: Discussionmentioning

confidence: 99%

“…16) Surgical resection of hemangiomas was performed in 6 of 9 patients with multiple lesions (Table 1). All lesions including asymptomatic ones were resected in one procedure in Case 5.…”

Section: Discussionmentioning

confidence: 99%

Multiple Cavernous Hemangiomas of the Skull Associated With Hepatic Lesions -Case Report-

Sasagawa

Akai

Yamamoto

et al. 2009

Neurol. Med. Chir.(Tokyo)

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A 55-year-old woman presented with multiple calvarial cavernous hemangiomas manifesting as right frontal swelling. Craniography and computed tomography showed an osteolytic lesion. Magnetic resonance imaging demonstrated multiple intraosseous lesions, and radioisotope bone scintigraphy identified even more numerous lesions. Total resection of the right frontal lesion and cranioplasty was performed. Histological examination confirmed the lesion as a cavernous hemangioma. Computed tomography of the abdomen revealed multiple hepatic lesions, which might be cavernous hemangiomas. Cavernous hemangioma is a rare bony tumor that should be considered in the differential diagnosis of skull tumors. A patient with multiple cavernous hemangiomas should undergo systemic examination to look for latent lesions, and regular follow-up examinations.

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“…Normalmente son lesiones únicas aunque se han reportado también pacientes con múltiples hemangiomas. En una revisión (Thomas et al 1975) encontró que sólo 2 de 43 pacientes con hemangiomas tenían múltiples lesiones 20 , sólo se han reportado 9 casos comprobados histológicamente con hemangiomas múltiples en cráneo (Tabla 1) 1,3,[7][8][9][10]15,19,2 . En este caso la paciente presentaba dos lesiones óseas a nivel de hueso frontal derecho y parietal izquierdo, confirmadas por histopatología como hemangiomas cavernosos con lo cual cumple los criterios para ingresar como el caso número diez a los reportados previamente en la literatura.…”

Section: -490 Figura 1 (A Y B)tomografía Axial Computarizada De Cunclassified

Hemangioma cavernoso multifocal en cráneo: Revisión de un caso

et al. 2010

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A 39 year old female presented with a multifocal lesions in the skull, at the frontal right and parietal left. We performed bilateral craniectomies guided with navigation, and the bone defects were repaired with titanium mesh. The pathological examination reported intraosseous cavernous hemangioma in both lesions. Follow up of six months without any complication or recurrence and good cosmetic outcome.

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Multifocal intradiploic cavernous hemangioma of the skull associated with nasal osteoma

Cited by 16 publications

References 12 publications

Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice

Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice

Multiple Cavernous Hemangiomas of the Skull Associated With Hepatic Lesions -Case Report-

Hemangioma cavernoso multifocal en cráneo: Revisión de un caso

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