Multifocal intracranial astrocytoma in a pediatric patient with Ollier disease

Bathla, Girish; Gupta, Somesh; Ong, Cheng Kang

doi:10.4103/0971-3026.95406

Cited by 14 publications

(20 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…131 Association with brain tumors, particularly cerebellar astrocytoma. 133 Loeys-Dietz syndrome 1A, 1B (OMIM: 609192, 610168) General information: Multisystem disorder dominated by cardiovascular pathology; prevalence less than .1 in 100,000.…”

Section: Congenital Hemidysplasia With Ichthyosiform Nevus and Limb Dmentioning

confidence: 99%

Neuroimaging Findings in Pediatric Genetic Skeletal Disorders: A Review

Wagner

Poretti

Benson

et al. 2016

Journal of Neuroimaging

View full text Add to dashboard Cite

Genetic skeletal disorders (GSDs) are a heterogeneous group characterized by an intrinsic abnormality in growth and (re-)modeling of cartilage and bone. A large subgroup of GSDs has additional involvement of other structures/organs beside the skeleton, such as the central nervous system (CNS). CNS abnormalities have an important role in long-term prognosis of children with GSDs and should consequently not be missed. Sensitive and specific identification of CNS lesions while evaluating a child with a GSD requires a detailed knowledge of the possible associated CNS abnormalities. Here, we provide a pattern-recognition approach for neuroimaging findings in GSDs guided by the obvious skeletal manifestations of GSD. In particular, we summarize which CNS findings should be ruled out with each GSD. The diseases (n = 180) are classified based on the skeletal involvement (1. abnormal metaphysis or epiphysis, 2. abnormal size/number of bones, 3. abnormal shape of bones and joints, and 4. abnormal dynamic or structural changes). For each disease, skeletal involvement was defined in accordance with Online Mendelian Inheritance in Man. Morphological CNS involvement has been described based on extensive literature search. Selected examples will be shown based on prevalence of the diseases and significance of the CNS involvement. CNS involvement is common in GSDs. A wide spectrum of morphological abnormalities is associated with GSDs. Early diagnosis of CNS involvement is important in the management of children with GSDs. This pattern-recognition approach aims to assist and guide physicians in the diagnostic work-up of CNS involvement in children with GSDs and their management.

show abstract

Section: Congenital Hemidysplasia With Ichthyosiform Nevus and Limb Dmentioning

confidence: 99%

Neuroimaging Findings in Pediatric Genetic Skeletal Disorders: A Review

Wagner

Poretti

Benson

et al. 2016

Journal of Neuroimaging

View full text Add to dashboard Cite

show abstract

“…shows cases of Ollier disease with gliomas diagnosed at a mean age of 23.7 years. [ 3 ] The incidence of CNS malignancies in Ollier disease is unknown because it is a rare entity, with only 19 cases described in the literature [ Table 1 ]. [ 3 ] The mean survival of the 19 patients with Ollier disease and CNS malignancy reported in the literature is not clear, but undoubtedly the prognosis for such patients is poor.…”

Section: Discussionmentioning

confidence: 99%

“…[ 3 ] The incidence of CNS malignancies in Ollier disease is unknown because it is a rare entity, with only 19 cases described in the literature [ Table 1 ]. [ 3 ] The mean survival of the 19 patients with Ollier disease and CNS malignancy reported in the literature is not clear, but undoubtedly the prognosis for such patients is poor. [ 9 ] In patients with non-Ollier disease astrocytomas, the median progression free survival (PFS) is 4.6 months and the overall survival (OS) is 20.5 months.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ollier disease with anaplastic astrocytoma: A review of the literature and a unique case

et al. 2016

View full text Add to dashboard Cite

Background:Ollier disease is a rare, nonfamilial disorder that primary affects the long bones and cartilage of joints with multiple enchondromas. It is associated with a higher risk of central nervous system (CNS) malignancies; although the incidence is unknown.Case Description:Here, we present the case of a 55-year-old woman who developed an anaplastic astrocytoma with a known diagnosis of Ollier disease with a survival time of over 3 years.Conclusion:This report draws attention to the rarity of this disease and the paucity of information regarding CNS involvement in Ollier disease, as well as reviews the current literature.

show abstract

“…Enchondromatosis or Ollier's disease (OD, World Health Organization (WHO) terminology) [2] is defined by the presence multiple enchondromas and characterized by an asymmetric distribution of cartilaginous lesions that can be extremely variable. It is first described by Maffucci in 1881 in association with venous an-giomas [4]. In 1899, Ollier described enchondromatosis in a patient with no evidence of vascular anomalies, known as OD [4].…”

Section: Introductionmentioning

confidence: 99%