Multifocal Insulinoma in Pancreas and Effect of Intraoperative Ultrasonography

Borazan, Ersin; Aytekin, Alper; Yılmaz, Latif; Elçi, Muhsin; Karaca, Mehmet Salih; Kervancıoğlu, Selim; Balık, Ahmet A.

doi:10.1155/2015/375124

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Although insulinomas are a rare disease, they are the most commonly diagnosed type of functional PanNET. Most cases reported in the literature are either case reports, case series or reviews [10][11][12][13][14][15][16][17]. Despite the nonspecificity of its symptoms, typical severe fasting hypoglycemia in nondiabetics and presence of Whipple triad should suggest a possible diagnosis of insulinoma, even may present with postprandial severe hypoglycemia [18].…”

Section: Discussionmentioning

confidence: 99%

Surgical management of insulinomas at the Azerbaijan Medical University: a retrospective study of 21 cases over a 10-year period

Hasanov¹,

Samadov²,

Bayramov³

et al. 2020

Turk J Med Sci

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Background/aim: This study represents the first report that evaluates the experience gathered from diagnosis, surgical treatment and outcome of insulinoma patients from Azerbaijan. Materials and methods: We retrospectively review of insulinoma patients for a 10-year period. Collected data included patient demographics, laboratory and imaging tests, detailed surgical reports, histopathological examination of resected specimens, and clinical follow-up. Results: Twenty-one insulinoma patients were identified. Male patients comprised 52.4%; mean age was 44 years. Mean time to diagnosis was 14 months; 61% patients had ≥3 medical referrals due to hypoglycemia-related symptoms. Diagnosis sensitivity of CT, MRI and US was 85%, 80%, and 55%, respectively. The mean glucose, insulin, C-peptide levels were 35.7 ± 9.5 mg/dL, 33.5 ± 21.9 µU/mL, and 3.74 ± 1.88 ng/mL, respectively. Pancreatic head and tail were the most frequent tumor locations; mean tumor size was 1.5 ± 0.7 cm. No statistical association was found between the tumor size and preoperative glucose, C-peptide and insulin levels. Distal pancreatectomy and enucleation were the most common surgical procedures. Local tumor recurrence rate was 14%. There was no mortality. Conclusions: To prevent delayed diagnoses, physicians should be familiar with the typical symptoms of these rare tumors.

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Section: Discussionmentioning

confidence: 99%

Surgical management of insulinomas at the Azerbaijan Medical University: a retrospective study of 21 cases over a 10-year period

Hasanov¹,

Samadov²,

Bayramov³

et al. 2020

Turk J Med Sci

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The value of fluorescence imaging in the intraoperative localization of small neuroendocrine tumors of the pancreas

Xi,

Jiang,

Zheng

et al. 2024

Preprint

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Objective To explore the effectiveness and safety of fluorescence imaging technology in the intraoperative localization of small neuroendocrine tumors of the pancreas. Methods Indocyanine green fluorescence imaging technology was used in operation, and the specific process of indocyanine green administration was as follows: 25 mg of indocyanine green was dissolved in 10 ml of sterilized water for injection, and 1 ml of indocyanine green was injected rapidly through the peripheral vein during the laparoscopic exploration of the tumor, and the tumor was observed to show green fluorescence about 1 min later, and the tumor showed green fluorescence, which was regarded as the success of development, and laparoscopic pancreatic tumor local excision surgery was carried out under the guidance of the real-time fluorescence imaging, and postoperative monitoring of the amylase index of drainage fluid to observe whether there was a pancreatic fistula. Under the real-time guidance of fluorescence imaging, laparoscopic pancreatic tumor local resection was performed, and the amylase index of the drainage fluid was monitored after surgery to observe whether pancreatic fistula occurred or not and to record the tumor grade, surgical margins, and other pathological conditions. RESULTS The fluorescence imaging effect of the two patients was good, the lesion boundary was clear, and both of them completed the local resection of the tumor laparoscopically without pancreatic fistula, and the pathology suggested that the pancreatic neuroendocrine tumors were grade G1, and the margins of the surgery were negative. CONCLUSION Fluorescence imaging technology helps to localize small pancreatic neuroendocrine tumors intraoperatively with good safety.

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Multifocal Insulinoma in Pancreas and Effect of Intraoperative Ultrasonography

Cited by 2 publications

References 10 publications

Surgical management of insulinomas at the Azerbaijan Medical University: a retrospective study of 21 cases over a 10-year period

Surgical management of insulinomas at the Azerbaijan Medical University: a retrospective study of 21 cases over a 10-year period

The value of fluorescence imaging in the intraoperative localization of small neuroendocrine tumors of the pancreas

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