Multifocal giant cell glioblastoma: Case report

Parekh, Harshad C.; Sharma, Rewati Raman; Prabhu, Sujit S.; Keogh, A. J.; Lynch, Patrick J.

doi:10.1016/0090-3019(93)90127-m

Cited by 15 publications

(8 citation statements)

References 6 publications

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“…11,14 These tumors are usually located supratentorially, mostly in the temporal lobe, and only rarely have they been reported infratentorially or within the spinal cord. 5,12 These tumors have been diagnosed primarily in younger adults with a peak incidence in the age group under 20 years of age 2 and in pediatric patients. A giant cell glioblastoma arising from the caudal brainstem has not been reported previously in adults.…”

Section: Discussionmentioning

confidence: 99%

Exophytic giant cell glioblastoma of the medulla oblongata

Luetjens

Mirzayan²,

Brandis

et al. 2009

JNS

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Giant cell glioblastoma is a rare variant within the spectrum of glioblastoma multiforme (GBM) tumors. A giant cell glioblastoma may be associated with a better prognosis than the common type of GBM after combined treatment involving tumor resection and radiochemotherapy. A giant cell glioblastoma may occur at various sites in the brain and spinal cord. To the authors' knowledge, this type of tumor has not been previously reported as arising as an exophytic tumor from the medulla oblongata. The authors report on a 40-year-old man who presented with a large tumor located in the caudal fourth ventricle. The tumor was removed completely and the patient underwent percutaneous radiotherapy with 60 Gy and concomitant chemotherapy with temozolomide. Histopathological examination of the tumor revealed the typical features of a giant cell glioblastoma. At the 2-year follow-up the patient was doing well and showed no signs of tumor recurrence. It is important to identify variants of GBM because they may predict favorable long-term outcome, even when they arise from the caudal brainstem.

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Section: Discussionmentioning

confidence: 99%

Exophytic giant cell glioblastoma of the medulla oblongata

Luetjens

Mirzayan²,

Brandis

et al. 2009

JNS

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“…Multifocal gliomas may either exhibit the same [15,16] or different histologies among the multiple intracranial tumors [17]. In a case report of a patient with an oligodendroglioma and a juvenile pilocytic astrocytoma, a deletion of chromosome 1p36 in the oligodendroglioma was reported, but not in the juvenile pilocytic astrocytoma.…”

Section: Pathologymentioning

confidence: 99%

Diagnosis and Management of Multifocal Gliomas

Giannopoulos¹,

Kyritsis²

2010

Oncology

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Patients who present with multiple cerebral tumors are usually considered as having metastatic disease. If they have a history of a primary cancer in another site, the brain tumors are considered metastases and are usually managed with standard whole-brain radiotherapy. If no primary cancer site is known, a diagnostic work-up is performed, but if no primary site is found, they are still considered as brain metastases from an unknown primary site. Thus, such patients can either have brain biopsy (recommended) for further diagnostic consideration or, occasionally, they can be treated with whole-brain radiotherapy, depending on the age, performance status and wish of the patient. However, in some of these patients the multiple brain tumors represent multifocal glioma rather than metastases, resulting in incorrect treatment. In such cases, various MRI characteristics may be helpful in directing towards the correct diagnosis. Thus, patients who present with multiple brain tumors should not always be considered to have metastatic disease even if they have a previous diagnosis of systemic cancer, and multifocal glioma should be ruled out.

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“…The CT and MRI findings of a case of giant cell glioblastoma were also described by Zipp, et al. [5] , and Parekh et al., in a 1993 paper, also published the CT findings of a case of multifocal GC [6] . Older cases including a radiologic description have also been published by Asklen, et al., who noted the radiologic appearance of the tumor to be well demarcated but otherwise without distinguishing features [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 63%

Imaging findings in the progression of a giant cell glioblastoma

Turner

Matthys

Heymann

et al. 2018

Radiology Case Reports

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First described in 1909, giant cell glioblastoma (GC) is a histologic variant of glioblastoma multiforme (GBM) that accounts for 1% of cases of primary GBM. It is characterized by a predominance of bizarre giant cells with abundant eosinophilic cytoplasm, and may portend an improved prognosis over classic GBM. Due to the rarity of GC, there is a paucity of reports that describe its associated radiologic findings. This case report chronicles the progression of a GC that was incidentally discovered in a 74-year-old male with coincident subdural hematoma and empyema. Serial brain imaging was obtained as part of this patient's continued work-up that documents the radiologic characteristics of the GC over a period of months. To our knowledge, this manuscript is the most extensive radiologic documentation of the progression of GC to date.

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Multifocal giant cell glioblastoma: Case report

Cited by 15 publications

References 6 publications

Exophytic giant cell glioblastoma of the medulla oblongata

Exophytic giant cell glioblastoma of the medulla oblongata

Diagnosis and Management of Multifocal Gliomas

Imaging findings in the progression of a giant cell glioblastoma

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