Multifocal eruptive cutaneous epithelioid angiomatous nodules

Cutaneous Epithelioid Angiomatous Nodule: Report of a New Case and Literature Review

“…CEAN is a rare vascular proliferative lesion, of which 66 cases have so far been reported after the initial description of this entity in 2004 [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ], including the case presented here. Clinically, CEAN presents as a bluish-red papule or nodule measuring 0.2–2.5 cm.…”

“…Cutaneous epithelioid angiomatous nodule (CEAN) is a rare benign vascular tumour of the skin first described by Brenn and Fletcher in 2004 [ 1 ], of which 65 cases have so far been reported [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. It belongs to the spectrum of epithelioid vascular proliferative lesions, including other neoplasms, either benign (such as epithelioid haemangioma and pyogenic granuloma) or malignant (such as epithelioid haemangioendothelioma and epithelioid angiosarcoma).…”

Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions

“…We performed a thorough search regarding CEAN using PubMed search engines and found 66 CEAN cases in 28 existing studies in English between 2004 and 2021 1–28 . These CEAN tumors were observed in patients (38 males and 28 females) aged 14–84 years (average, 42.0 years).…”

“…A cutaneous epithelioid angiomatous nodule (CEAN) is a rare cutaneous vascular entity first described in 2004 by Brenn and Fletcher 1 . Since then, 66 cases have been reported in 28 papers 1–28 . Owing to the histopathological features of the epithelioid endothelial cells, this benign tumor can be easily confused with other benign, borderline, or malignant vascular tumors, including bacillary angiomatosis, Kaposi sarcoma, epithelioid hemangioendothelioma, and epithelioid angiosarcoma.…”

Infection: Bacteria, Spirochetes, Protozoa, and Infestation

“…Although histopathologically similar to bacillary angiomatosis, verruca peruana would lack the perivascular aggregates of bacilli. Cutaneous epithelioid angiomatous nodule, a recently reported and rare vascular proliferation, presents as a well-circumscribed, unilobular, and cellular proliferation of plump endothelial cells with vacuolated cytoplasm and prominent nucleoli [41]. A central stromal component is prominent.…”