Multifocal desmoplastic fibromas of the mandible

Herford, Alan S.; Reder, Paul; Ducic, Yadranko

doi:10.1053/joms.2001.25032

Cited by 23 publications

(6 citation statements)

References 22 publications

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“…In the present study, 19 (86.4%) of the cases diagnosed as MF were immunopositive for α‐SMA, in agreement with the findings of Abramowicz et al (), Allon et al (), Foss and Ellis (), Linos et al (), Lopes et al (), Vered, Allon, Buchner, and Dayan (), and Trejo‐Scorza et al (). Only one DF case, (10%) was positive for α‐SMA, being similar to the literature (Herford, Reder, & Ducic, ; Schneider et al, ; Shi, Wang, Wang, & Yu, ). However, a broader discussion of this result with literature data is not possible because there are no studies investigating various cases of DF with α‐SMA immunohistochemistry.…”

Section: Discussionsupporting

confidence: 88%

Myofibroblastic lesions in the oral cavity: Immunohistochemical and ultrastructural analysis

et al. 2018

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Section: Discussionsupporting

confidence: 88%

Myofibroblastic lesions in the oral cavity: Immunohistochemical and ultrastructural analysis

et al. 2018

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“…El grado de celularidad puede variar de área en área dentro de una misma lesión, en las zonas más celulares los fibroblastos se observan más gruesos y redondos dentro de un estroma con menos colágeno 10 . No hay Fibroma desmoplásico de maxilar en paciente pediátrico: reporte de caso atipia celular, hay pocos eventos mitóticos 3,1 .…”

Section: Discussionunclassified

Fibroma desmoplásico de maxilar en paciente pediátrico: Reporte de caso

Mora¹,

Mora²,

Jiménez³

2021

Rev. Odontopediatr. Latinoam.

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La presencia de tumefacciones en la cavidad bucal del paciente pediátrico puede ser indicativo de gran cantidad de patologías y enfermedades sistémicas, algunas incluso pueden perjudicar el bienestar del mismo. El Fibroma desmoplásico es un tumor óseo benigno, localmente destructivo, catalogado como muy poco frecuente. Se reporta el caso de un niño de 4 años con fibroma desmoplásico en el maxilar de alrededor de 2 años de evolución, observándose como una tumefacción generalizada del segundo cuadrante, con ausencia de signos y síntomas de inflamación. Por su edad representa un reto para el clínico ya que el abordaje debe ser interdisciplinario con profesionales expertos en odontopediatría, cirugía y patología. Se describe a profundidad cada paso del proceso diagnóstico incluyendo hallazgos clínicos, radiográficos e histológicos, así como la toma de la muestra para su estudio.

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“…Grossly, the tumor is poorly circumscribed within the bone having a rubbery fibrous appearance 3. Only one case of multiple asynchronous DF involving the gnathic bones was reported 18. Histologically, the lesion is poorly demarcated and characterized by the presence of hypocellular collagen-rich stroma with few remnants of thin bony trabeculae 4.…”

Section: Discussionmentioning

confidence: 99%

Desmoplastic fibroma of the mandible: a rare gnathic bone tumor with a review of the literature

2019

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Desmoplastic fibroma (DF) is a rare bone tumor, which is known to involve mostly the gnathic bones. In this setting, the clinical presentation is usually represented by a bulging tumor of the face. Radiologically, the tumor is usually characterized by an expansile lytic bone lesion. The histopathology of the tumor shows a poorly circumscribed hypocellular lesion rich in collagen fibers with interspersed spindle cells having bland nuclear chromatin. Despite the lack of mitoses and nuclear pleomorphism, DF has an aggressive nature, presenting as a destructive growth causing entrapment of neuro-vascular bundles, sinusitis, or trismus. Some cases of DF show mutations in the adenomatous polyposis coli pathway shown by nuclear localization of the β-catenin protein. Few reports showed an association with tuberous sclerosis, though most of these cases were sporadic. We discuss a rare case of desmoplastic fibroma involving the mandible, and a review of the literature of the DF cases involving the gnathic bones.

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Multifocal desmoplastic fibromas of the mandible

Cited by 23 publications

References 22 publications

Myofibroblastic lesions in the oral cavity: Immunohistochemical and ultrastructural analysis

Myofibroblastic lesions in the oral cavity: Immunohistochemical and ultrastructural analysis

Fibroma desmoplásico de maxilar en paciente pediátrico: Reporte de caso

Desmoplastic fibroma of the mandible: a rare gnathic bone tumor with a review of the literature

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