Multifocal choroiditis and panuveitis

Mycophenolate mofetil therapy in uveitis: analysis of eight cases in a tertiary ophthalmic care centre in India

“…More recently, biological response modifiers targeting the immune system have been tried, which include immunomodulatory therapy [23], anti-TNF therapy (infliximab [25], etanercept [26], and adalimumab), monoclonal antibodies to cytokine receptors (anti-interleukin-2 receptor daclizumab [27]), and T-cell subsets (Campath). Though designed to be more specific, clinical experience remains limited.…”

“…Visual acuity was noted in both eyes in bilateral disease, but the better eye was considered for interpreting results [23]. A ''steroid-sparing'' effect was said to have been achieved if there was a 50% reduction in the dose of prednisolone from baseline or if the maintenance dose was 10 mg per day with stable uveitis.…”

Efficacy of Anti-VEGF and Subtenon Injection of Triamcinolone Acetonide for Choroidal Neovascularization Associated with Multifocal Choroiditis

“…It is reported to be associated with viral infection, or other infection diseases such as tuberculosis or syphilis [8]. There is no proven therapy for MC.…”

Immunomodulatory Medications in Uveitis

“…[51][52][53] Multifocal choroiditis with panuveitis can be controlled temporarily with steroids, but its chronicity results not only in a multitude of steroid side effects but also vision loss. [54][55][56] In a recent retrospective study, 57 almost all patients' eyes on steroid therapy alone lost significant vision, whereas eyes of patients that were treated with immunomodulatory therapy (IMT) (azathioprine/cyclosporine) retained good vision (>20/80) (Level B2).…”

“…57,[104][105][106][107][108][109] In the larger of these studies, 104 160 patients were observed. Control of inflammation was achieved in 76%, and steroid-sparing effect was achieved in 56%.…”