Multifocal chorioretinal lesions in Borzoi dogs

Storey, Eric S.; Grahn, Bruce H; Alcorn, Jane

doi:10.1111/j.1463-5224.2005.00423.x

Cited by 17 publications

(29 citation statements)

References 11 publications

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“…S1 ). These ‘bull's eye’ lesions are most consistent with multifocal acquired chorioretinopathy (MAC), a disorder previously reported in herding and working dogs [33]–[36]. According to information provided by the dog owners, at least some of the Swedish vallhund dogs with MAC-like lesions suffered from severe gastrointestinal parasitism early in life which may have resulted in multifocal chorioretinitis.…”

Section: Resultsmentioning

confidence: 54%

A Novel Form of Progressive Retinal Atrophy in Swedish Vallhund Dogs

et al. 2014

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Inherited retinal degenerations, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), represent leading causes of incurable blindness in humans. This is also true in dogs, where the term progressive retinal atrophy (PRA) is used to describe inherited photoreceptor degeneration resulting in progressive vision loss. Because of the similarities in ocular anatomy, including the presence of a cone photoreceptor-rich central retinal region, and the close genotype-phenotype correlation, canine models contribute significantly to the understanding of retinal disease mechanisms and the development of new therapies. The screening of the pure-bred dog population for new forms of PRA represents an important strategy to establish new large animal models. By examining 324 dogs of the Swedish vallhund breed in seven countries and across three continents, we were able to describe a new and unique form of PRA characterized by the multifocal appearance of red and brown discoloration of the tapetal fundus followed over time by thinning of the retina. We propose three stages of the disease based on the appearance of the ocular fundus and associated visual deficits. Electroretinography revealed a gradual loss of both rod and cone photoreceptor-mediated function in Stages 2 and 3 of the disease. In the few dogs that suffered from pronounced vision loss, night-blindness occurred first in late Stage 2, followed by decreased day-vision in Stage 3. Histologic examinations confirmed the loss of photoreceptor cells at Stage 3, which was associated with the accumulation of autofluorescent material in the adjacent retinal pigment epithelium. Pedigree analysis was suggestive of an autosomal-recessive mode of inheritance. Mutations in six known canine retinal degeneration genes as well as hypovitaminosis E were excluded as causes of the disease. The observed variability in the age of disease onset and rate of progression suggest the presence of genetic and/or environmental disease modifiers.

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Section: Resultsmentioning

confidence: 54%

A Novel Form of Progressive Retinal Atrophy in Swedish Vallhund Dogs

et al. 2014

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“…Chorioretinal degeneration, which may be related to the destruction of the choriocapillaris and/or tapetum, has been observed in Borzoi dogs . Similar chorioretinal lesions were diagnosed in the examined group of German Shepherd dogs.…”

Section: Discussionsupporting

confidence: 68%

“…Similar chorioretinal lesions were diagnosed in the examined group of German Shepherd dogs. Fluorescein angiography conducted by Storey et al . did not show evidence of fluorescein leakage, which confirmed an intact blood–ocular barrier.…”

Section: Discussionmentioning

confidence: 76%

“…However, the latter lesions, although similar to those observed in the examined group of German Shepherds, did not progress over a period of several years; they were unrelated to any systemic disorders, nor were they hereditary. Their etiology remains unknown …”

Section: Discussionmentioning

confidence: 99%

“…Oval areas of tapetal hyper‐reflectivity with pigmented centers were observed in Borzoi dogs. The observed lesions were noncongenital, and their etiology was unknown . Focal or multifocal, irregular, small to large, hyper‐reflective lesions with pigmented areas have been observed in Czechoslovakian Wolfdogs.…”

Section: Introductionmentioning

confidence: 99%

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