Multifaceted roles of pollen in the management of cancer

Kolipaka, Tejaswini; Khairnar, Pooja; Phatale, Vivek; Pandey, Giriraj; Famta, Paras; Shah, Saurabh; Asthana, Amit; Nanduri, Srinivas; Raghuvanshi, Rajeev Singh; Srivastava, Saurabh

doi:10.1016/j.ijpharm.2023.123278

Cited by 8 publications

(4 citation statements)

References 129 publications

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“…At present, an extensive variety of nanoformulations have been developed and examined for the delivery of various therapeutics, such as vaccines, proteins, and nucleic acids. , NPs possess several benefits, including size-dependent physical characteristics, protection against chemical or proteolytic degradation, controlled release over a more extended period, and targeted delivery to specific body regions, which minimizes side effects. , Desai et al developed and examined the therapeutic effectiveness of the anti-nociception agent capsaicin (Cap) and anti-TNFα siRNA (siTNFα) entrapped polymeric NCs (CyLiPns) for the treatment of chronic inflammatory skin disorders . Currently, nanomedicines have been delivered using a variety of delivery strategies, including nasal, subcutaneous, oral, and intravenous injections . However, injections require an authorized person for administration, are painful, and carry the risk of infections at the injection site.…”

Section: Superiority Of Nc-integrated Mns Over Other Drug Delivery Pl...mentioning

confidence: 99%

“…157 Currently, nanomedicines have been delivered using a variety of delivery strategies, including nasal, subcutaneous, oral, and intravenous injections. 158 However, injections require an authorized person for administration, are painful, and carry the risk of infections at the injection site. This necessitates alternate routes of administration for more regulated and effective delivery of active substances.…”

Section: Superiority Of Nc-integrated Mns Over Other Drug Delivery Pl...mentioning

confidence: 99%

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Nanocarrier-Integrated Microneedles: Divulging the Potential of Novel Frontiers for Fostering the Management of Skin Ailments

Khairnar,

Phatale,

Shukla

et al. 2024

Mol. Pharmaceutics

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The various kinds of nanocarriers (NCs) have been explored for the delivery of therapeutics designed for the management of skin manifestations. The NCs are considered as one of the promising approaches for the skin delivery of therapeutics attributable to sustained release and enhanced skin penetration. Despite the extensive applications of the NCs, the challenges in their delivery via skin barrier (majorly stratum corneum) have persisted. To overcome all the challenges associated with the delivery of NCs, the microneedle (MN) technology has emerged as a beacon of hope. Programmable drug release, being painless, and its minimally invasive nature make it an intriguing strategy to circumvent the multiple challenges associated with the various drug delivery systems. The integration of positive traits of NCs and MNs boosts therapeutic effectiveness by evading stratum corneum, facilitating the delivery of NCs through the skin and enhancing their targeted delivery. This review discusses the barrier function of skin, the importance of MNs, the types of MNs, and the superiority of NC-loaded MNs. We highlighted the applications of NC-integrated MNs for the management of various skin ailments, combinational drug delivery, active targeting, in vivo imaging, and as theranostics. The clinical trials, patent portfolio, and marketed products of drug/NC-integrated MNs are covered. Finally, regulatory hurdles toward benchtop-to-bedside translation, along with promising prospects needed to scale up NC-integrated MN technology, have been deliberated. The current review is anticipated to deliver thoughtful visions to researchers, clinicians, and formulation scientists for the successful development of the MN-technology-based product by carefully optimizing all the formulation variables.

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Section: Superiority Of Nc-integrated Mns Over Other Drug Delivery Pl...mentioning

confidence: 99%

Section: Superiority Of Nc-integrated Mns Over Other Drug Delivery Pl...mentioning

confidence: 99%

Nanocarrier-Integrated Microneedles: Divulging the Potential of Novel Frontiers for Fostering the Management of Skin Ailments

Khairnar,

Phatale,

Shukla

et al. 2024

Mol. Pharmaceutics

Self Cite

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“…Bees prepare their pollen by mixing their secretions with pollen collected from flowers, resulting in granules containing thousands of pollen grains approximately 1.4 mm–4 mm in size [ 40 ]. It is the primary source of nutrients for bees due to its high composition [ 75 , 76 ]. Bee pollen provides many health benefits to humans due to its abundance of proteins, carbohydrates, dietary fiber, and mainly polyunsaturated fatty acids.…”

Section: Chemical Properties Of Bee Productsmentioning

confidence: 99%

Potential application of bee products in food industry: An exploratory review

Maicelo-Quintana,

Reyna-Gonzales,

Balcázar-Zumaeta

et al. 2024

Heliyon

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“…The feasibility and efficacy of these microswarms in eliminating bacterial biofilms in clinical biliary stents were demonstrated. It is worth noting that pollen is generally recognized as safe material by the Food and Drug Administration (FDA), making it more easily approved for use in oral and gastrointestinal pharmaceutical preparations [92]. With its favorable biocompatibility, biodegradability, and controlled release behavior, pollen-based magnetic robots offer an innovative approach to effective disease treatment and hold great potential for clinical applications.…”

Section: Pollenmentioning

confidence: 99%

Bio-Hybrid Magnetic Robots: From Bioengineering to Targeted Therapy

Zhang,

Zeng,

Zhao

et al. 2024

Bioengineering

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Magnetic robots possess an innate ability to navigate through hard-to-reach cavities in the human body, making them promising tools for diagnosing and treating diseases minimally invasively. Despite significant advances, the development of robots with desirable locomotion and full biocompatibility under harsh physiological conditions remains challenging, which put forward new requirements for magnetic robots’ design and material synthesis. Compared to robots that are synthesized with inorganic materials, natural organisms like cells, bacteria or other microalgae exhibit ideal properties for in vivo applications, such as biocompatibility, deformability, auto-fluorescence, and self-propulsion, as well as easy for functional therapeutics engineering. In the process, these organisms can provide autonomous propulsion in biological fluids or external magnetic fields, while retaining their functionalities with integrating artificial robots, thus aiding targeted therapeutic delivery. This kind of robotics is named bio-hybrid magnetic robotics, and in this mini-review, recent progress including their design, engineering and potential for therapeutics delivery will be discussed. Additionally, the historical context and prominent examples will be introduced, and the complexities, potential pitfalls, and opportunities associated with bio-hybrid magnetic robotics will be discussed.

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Multifaceted roles of pollen in the management of cancer

Cited by 8 publications

References 129 publications

Nanocarrier-Integrated Microneedles: Divulging the Potential of Novel Frontiers for Fostering the Management of Skin Ailments

Nanocarrier-Integrated Microneedles: Divulging the Potential of Novel Frontiers for Fostering the Management of Skin Ailments

Potential application of bee products in food industry: An exploratory review

Bio-Hybrid Magnetic Robots: From Bioengineering to Targeted Therapy

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