Multifaceted Roles of AFG3L2, a Mitochondrial ATPase in Relation to Neurological Disorders
Ranita Ghosh Dastidar,
Saradindu Banerjee,
Piyush Behari Lal
et al.
Abstract:AFG3L2 is a zinc metalloprotease and an ATPase localized in an inner mitochondrial membrane involved in mitochondrial quality control of several nuclear- and mitochondrial-encoded proteins. Mutations in AFG3L2 lead to diseases like slow progressive ataxia, which is a neurological disorder. This review delineates the cellular functions of AFG3L2 and its dysfunction that leads to major clinical outcomes, which include spinocerebellar ataxia type 28, spastic ataxia type 5, and optic atrophy type 12. It summarizes… Show more
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