Multifaceted Factors Causing Conflicting Outcomes in Herb-Drug Interactions

Choi, Young Hee; Chin, Young‐Won

doi:10.3390/pharmaceutics13010043

Cited by 25 publications

(21 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering that numerous reports the inhibitory effects of mangosteen pericarp extract and xanthones as main components of mangosteen pericarp extract against P-gp [61,62], the increased donepezil concentration in the brain may be due to the inhibition of P-gp-mediated donepezil efflux through BBB by WMP. Although P-gp is expressed in many other organs, the degree of P-gp inhibition by P-gp inhibitors are different because the concentrations of P-gp inhibitor in the specific tissue are various, with different inhibiting P-gp activities [61,63,64]. In this view, WMP might significantly inhibit only P-gp mediated donepezil efflux through BBB, not in the intestine.…”

Section: Discussionmentioning

confidence: 99%

Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice

et al. 2021

Self Cite

View full text Add to dashboard Cite

The pharmacokinetic (PK) change in a drug by co-administered herbal products can alter the efficacy and toxicity. In the circumstances that herb–drug combinations have been increasingly attempted to alleviate Alzheimer’s disease (AD), the PK evaluation of herb–drug interaction (HDI) is necessary. The change in systemic exposure as well as target tissue distribution of the drug have been issued in HDIs. Recently, the memory-enhancing effects of water extract of mangosteen pericarp (WMP) has been reported, suggesting a potential for the combination of WMP and donepezil (DNP) for AD treatment. Thus, it was evaluated how WMP affects the PK change of donepezil, including systemic exposure and tissue distribution in mice after simultaneous oral administration of DNP with WMP. Firstly, co-treatment of WMP and donepezil showed a stronger inhibitory effect (by 23.0%) on the neurotoxicity induced by Aβ(25–35) in SH-SY5Y neuroblastoma cells than donepezil alone, suggesting that the combination of WMP and donepezil may be more effective in moderating neurotoxicity than donepezil alone. In PK interaction, WMP increased donepezil concentration in the brain at 4 h (by 63.6%) after administration without affecting systemic exposure of donepezil. Taken together, our results suggest that WMP might be used in combination with DNP as a therapy for AD.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although there is not strong scientific evidence that supports any claim of efficacy of herbal supplements in the management of viral infections such as COVID-19, their use is prevalent in many countries, especially in the Far East [ 10 , 11 , 12 , 13 , 14 ]. These practices continue despite the fact that the use of herbs and bioactives has the potential to lead to pharmacokinetic or pharmacodynamic changes in many commonly used medications, particularly in the elderly [ 15 ]. Moreover, the WHO reported that the use of traditional and complementary medicine varies widely throughout the world and ranges from 1% to 99% of the population depending upon the country and local customs [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Commonly Utilized Natural Products during the COVID-19 Pandemic in Saudi Arabia: A Cross-Sectional Online Survey

AlNajrany

Asiri

Sales

et al. 2021

IJERPH

View full text Add to dashboard Cite

Objectives: The utilization rate of herbal and dietary supplements among the Saudi population is reported to be high. However, the utilization rate and types of herbal and dietary supplements during the COVID-19 pandemic are largely unknown. Methods: This was an online questionnaire-based cross-sectional study that used convenience sampling and social media platforms (Telegram®, Twitter®, and WhatsApp®) to disseminate a 12-item questionnaire across the Saudi general public aged 18 years and above. The questionnaire inquired about the sociodemographic characteristics (e.g., age, gender, education, geographical location), presence of chronic health conditions and the use of prescription medications, awareness of the viral nature of COVID-19 infection and its common symptoms, and the commonly utilized herbal and/or dietary supplements. Results: Sixty-four percent of the 1473 participants reported using herbal and/or dietary supplements for the purpose of boosting their immune system to prevent COVID-19 infection. In addition, 88.2% of the respondents were misinformed about the manifestation of COVID-19 symptoms. Most of the participants were Saudi (91.9%), aged 49 years and younger (83%), female (52%), and healthy (81%). Honey (46%), lemon (45%), ginger (36%), vitamin C (32%), black seed (26%), garlic (26%), and turmeric (19%) were the most commonly used herbal and/or dietary supplements by the participants. Saudi nationals (OR = 1.67, 95% CI: 1.08 to 2.6, p = 0.02), older adults (OR = 1.30, 95% CI:1.10 to 1.55, p = 0.002), and those taking prescription medications had higher odds of using dietary and/or herbal supplements (OR = 3.31, 95% CI: 2.61 to 4.18, p < 0.0001). Conclusion: The utilization rate of herbal and dietary supplements among the Saudi public during the COVID-19 pandemic is high. Future studies should examine the impact of different public awareness campaigns aimed at improving the public knowledge of the risk and benefits associated with the use of different commonly utilized herbal and dietary products identified in this study.

show abstract

“…Human medical metabolism studies of natural products are usually limited to the secondary metabolites, which are used as single-substance drugs, e.g., in cancer therapy, as anti-infectives or as immunosuppressants [ 8 ]. The metabolic fate of compounds from herbal medicines (“botanicals”) is not well covered by research [ 9 , 10 ], although its importance is understood [ 11 , 12 , 13 , 14 ]. The lack of data on, and lack of understanding of, the pharmacokinetic interaction of herbal drug constituents with the drugged organism is known as one of the major hurdles in the development of herbal medicines as fully accepted mainstream drugs/therapeutics.…”

Section: Introductionmentioning

confidence: 99%

Combining HPLC-DAD-QTOF-MS and HPLC-SPE-NMR to Monitor In Vitro Vitetrifolin D Phase I and II Metabolism

et al. 2021

View full text Add to dashboard Cite

By combining HPLC-DAD-QTOF-MS and HPLC-SPE-NMR, the in vitro metabolism of vitetrifolin D, a pharmacologically active key molecule from Vitex agnus-castus in liver cell fractions, was investigated. Twenty-seven phase I and phase II metabolites were tentatively identified from the culture broth by HPLC-DAD-QTOF-MS. The subsequent HPLC-SPE-NMR analysis allowed for the unequivocal structural characterization of nine phase I metabolites. Since the preparative isolation of the metabolites was avoided, the substance input was much lower than in conventional strategies. The study did prove that the use of hyphenated instrumental analysis methodologies allows for the successful performance of in vitro metabolism studies, even if the availability of substances is very limited.

show abstract

Multifaceted Factors Causing Conflicting Outcomes in Herb-Drug Interactions

Cited by 25 publications

References 82 publications

Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice

Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice

The Commonly Utilized Natural Products during the COVID-19 Pandemic in Saudi Arabia: A Cross-Sectional Online Survey

Combining HPLC-DAD-QTOF-MS and HPLC-SPE-NMR to Monitor In Vitro Vitetrifolin D Phase I and II Metabolism

Contact Info

Product

Resources

About