Multifaceted Effects of Intermittent Fasting on the Treatment and Prevention of Diabetes, Cancer, Obesity or Other Chronic Diseases

Abstract

Background: Obesity and diabetes are global epidemics that result in a slew of co-morbid illnesses. Both have been linked to an increased risk of hormonal imbalance, cancer, and other significant disorders, which are a concerning trend for cancer rates in the backdrop of rising obesity and diabetes rates worldwide. Around one in ten persons in the United States and Canada have serious illnesses correlated with type 2 diabetes and early death. It is believed that the US economy alone spends $245 billion annually. Lifestyle modification with intermittent fasting protocol and proper diet helps lower the blood glucose level and maintain the body mass index and reduced the inflammation in the body which is the main cause for all chronic diseases. Methods: We searched case series, clinical trials relating to type 2 diabetes, insulin resistance, cancer, thyroid, cardiovascular disease or other inflammatory diseases in response to intermittent fasting in the PubMed, MEDLINE, and Google Scholar databases. Objective: In this review, we focused on intermittent fasting-based approaches that are becoming more widely accepted for improving health and reducing unwanted effects in patients with type 2 diabetes, cancer, cardiovascular disease, neurodegenerative disease, obesity, thyroid, and hormonal imbalance, which are fasting intermittently and whether intermittent fasting may be considered as a non-medicinal therapeutic option for persons suffering from chronic diseases. Conclusion : Intermittent fasting successfully reversed the diabetes, thyroid, high blood pressure, elevated lipid level, and maintained the body mass index along and also studies has shown that it has been followed or instructed for the treatment and prevention of cancer and neurodegenerative diseases with dietary interventions.

Neuroendocrine Tumors: A Comprehensive Review on Nutritional Approaches

“…In this regard, MD represents a healthful eating pattern, which can improve glycemic profile, and delay the need for antidiabetic drug therapy, as also recommended by the American Diabetes Association (ADA) guidelines [ 146 ]. On the other hand, KD may represent an alternative, due to insulin-sensitizing effects, reduction in blood glucose, and insulin-like growth factor, which are important drivers of cancer cell proliferation; similarly, IF protocol could ameliorate glucose metabolism, maintain the BMI, and reduce inflammation [ 147 ].…”

The effects of intermittent fasting diet on quality of life, clinical symptoms, inflammation, and oxidative stress in overweight and obese postmenopausal women with rheumatoid arthritis: study protocol of a randomized controlled trial

“…Intermittent fasting (IF) diets have recently become popular for improvement in many chronic diseases [ 21 ]. IF is one of the types of fasting diet suggested by experts and various studies because the potential benefits of weight control, cardiovascular health, and oxidative stress reduction make it an attractive option [ 22 ].…”