Multifaceted Chemistry of Tetrazole. Synthesis, Uses, and Pharmaceutical Applications

Fe3O4@SiO2@SBA-3@CPTMS@Arg-Cu: preparation, characterization, and catalytic performance in the conversion of nitriles to amides and the synthesis of 5-substituted 1H-tetrazoles

“…The separation of magnetic catalysts via magnetic separation is an attractive alternative to ltration or centrifugation for separating solid catalysts. Tetrazoles are a class of synthetic organic heterocyclic compounds that have numerous applications, especially in the elds of medicine, 24 biochemistry, 25 pharmacology, 26 and in industry as materials, 27 e.g., in photography, 28 imaging chemicals, 29 and the military. 30 Various methods have been reported in the literature for the preparation of tetrazoles.…”

Catalytic Tetrazole Synthesis via [3+2] Cycloaddition of NaN3 to Organonitriles Promoted by Co(II)-complex: Isolation and Characterization of a Co(II)-diazido Intermediate

“…Tetrazoles are the highest number of nitrogen atoms containing thermally stable heterocyclic compounds. These unnatural heterocyclic compounds have largely manifested their applications in medicinal chemistry and pharmaceutical science. − Due to the longer biodisponibility, the tetrazole moiety increases the activity of the drug without affecting the active pharmaceutical ingredient. Furthermore, the acidic nature of 5-substituted 1H-tetrazoles renders them to act as bioisosteric replacements of carboxylic acids. − A large variety of tetrazole fragments containing drug molecules have been reported to date. − Due to their high energy properties, tetrazole derivatives also found their applications as potential explosives and in the manufacturing of high-energy materials. − Furthermore, tetrazole derivatives are used for the preparation of ligands for various kinds of coordination complexes. − These nitrogen-rich heterocyclic compounds are also extensively used as effective organocatalysts. − …”

Synthesis, ADME Profiling, Antibacterial Screening and Molecular Docking of Some New Tetrazole‐Heterocycle Hybrids

“…Moreover, modern medicinal chemistry researches suggest the development of novel tetrazoles due to their prospective therapeutic relevance and broad biological actions. [17,18] In particular, great efforts have been offered over the past two decades to develop and identify new tetrazole hybrids as potential antibacterial therapies. [13] Schiff bases are extensively employed for many biological and commercial purposes because they demonstrated effectiveness as anti-inflammatory, [19] anticancer, [20,21] antidiabetic, [22] antioxidant [23] and antibacterial [24,25] agents.…”

“…In addition to having antiviral [9] and anticancer [10] properties, the tetrazole moiety also has anti‐inflammatory, [11] antifungal [12] and antibacterial [13–16] properties. Moreover, modern medicinal chemistry researches suggest the development of novel tetrazoles due to their prospective therapeutic relevance and broad biological actions [17,18] . In particular, great efforts have been offered over the past two decades to develop and identify new tetrazole hybrids as potential antibacterial therapies [13] …”